Pancreatic acinar atrophy in German shepherd dogs and rough‐coated Collies. Etiopathogenesis, diagnosis and treatment. A review

Me, Wiberg

doi:10.1080/01652176.2004.9695169

Cited by 20 publications

(16 citation statements)

References 90 publications

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“…Affected dogs can be treated with pancreatic enzyme supplements, although dogs with EPI are sometimes euthanized because of the expense associated with treatment or a poor response to treatment (Hall et al 1991; Wiberg and Westermarck 2002). PAA is widespread in the GSD population and affects other breeds including the Collie and Eurasian (Proschowsky and Fredholm 2007; Wiberg 2004). A recent test mating in the GSD shows that EPI is likely a polygenic disorder (Westermarck et al 2010).…”

Section: Introductionmentioning

confidence: 99%

Genome-wide association studies for multiple diseases of the German Shepherd Dog

et al. 2011

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The German Shepherd Dog (GSD) is a popular working and companion breed for which over 50 hereditary diseases have been documented. Herein, SNP profiles for 197 GSDs were generated using the Affymetrix v2 canine SNP array for a genome-wide association study to identify loci associated with four diseases: pituitary dwarfism, degenerative myelopathy (DM), congenital megaesophagus (ME), and pancreatic acinar atrophy (PAA). A locus on Chr 9 is strongly associated with pituitary dwarfism and is proximal to a plausible candidate gene, LHX3. Results for DM confirm a major locus encompassing SOD1, in which an associated point mutation was previously identified, but do not suggest modifier loci. Several SNPs on Chr 12 are associated with ME and a 4.7 Mb haplotype block is present in affected dogs. Analysis of additional ME cases for a SNP within the haplotype provides further support for this association. Results for PAA indicate more complex genetic underpinnings. Several regions on multiple chromosomes reach genome-wide significance. However, no major locus is apparent and only two associated haplotype blocks, on Chrs 7 and 12 are observed. These data suggest that PAA may be governed by multiple loci with small effects, or it may be a heterogeneous disorder.

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Section: Introductionmentioning

confidence: 99%

Genome-wide association studies for multiple diseases of the German Shepherd Dog

et al. 2011

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“…In this breed, PAA is inherited in an autosomal recessive manner and may be autoimmune in origin. [1][2][3][4][5][6][7] PAA is also inherited in Rough-Coated Collies (RCC), and is again presumed to be autoimmune. [5][6][7][8] EPI has been reported in other breeds, and EPI in related English Setters in Italy has been described.…”

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confidence: 99%

“…[1][2][3][4][5][6][7] PAA is also inherited in Rough-Coated Collies (RCC), and is again presumed to be autoimmune. [5][6][7][8] EPI has been reported in other breeds, and EPI in related English Setters in Italy has been described. 9 Cases of EPI caused by chronic pancreatitis (CP) have been reported, but given the difficulties with diagnosis, CP may be a more common cause of EPI in dogs than is currently recognized.…”

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confidence: 99%

Breed Associations for Canine Exocrine Pancreatic Insufficiency

et al. 2007

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An association with EPI in Chows has not previously been reported. In breeds with early-onset EPI, immune-mediated mechanisms are possible or the disease may be congenital. When EPI manifests later, as in CKCS, pathogenesis is likely different (eg, secondary to chronic pancreatitis). Underrepresentation of certain breeds among dogs with EPI has not previously been recognized and may imply the existence of breed-specific mechanisms that protect pancreatic tissue from injury.

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“…Canine EPI usually results from pancreatic acinar atrophy (PAA) and has been reported to be most common in the German shepherd [20]. Chronic pancreatitis is also a possible cause of EPI but is less commonly diagnosed in dogs than in humans or cats [19].…”

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confidence: 99%

“…Chronic pancreatitis is also a possible cause of EPI but is less commonly diagnosed in dogs than in humans or cats [19]. Clinical manifestations of EPI have rarely been reported in dogs less than 6 months old [20].…”

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confidence: 99%

Juvenile Diabetes Mellitus Accompanied by Exocrine Pancreatic Insufficiency in a Dog

Kang

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. A 6-month-old male crossbred dog weighing 0.78 kg was presented with acute bilateral immature cataracts, intermittent diarrhea and growth retardation. The clinical manifestations and laboratory findings were suggestive of concurrent juvenile diabetes mellitus (DM) and exocrine pancreatic insufficiency (EPI). Moreover, the DM was associated with a decreased level of serum insulin-like growth factor I. Histological examination revealed a markedly lower number of pancreatic islets and acinar cells. This case shows that juvenileonset DM can occur simultaneously with EPI and result in growth retardation, acute cataract formation and a high cortisol concentration.

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Pancreatic acinar atrophy in German shepherd dogs and rough‐coated Collies. Etiopathogenesis, diagnosis and treatment. A review

Cited by 20 publications

References 90 publications

Genome-wide association studies for multiple diseases of the German Shepherd Dog

Genome-wide association studies for multiple diseases of the German Shepherd Dog

Breed Associations for Canine Exocrine Pancreatic Insufficiency

Juvenile Diabetes Mellitus Accompanied by Exocrine Pancreatic Insufficiency in a Dog

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