Palmoplantar pustulosis and pustulotic arthro‐osteitis treatment with potassium iodide and tetracycline, a novel remedy with an old drug: a review of 25 patients

Abstract

Treatment with KI and/or its combination with tetracycline may be a useful treatment for PPP/PAO. Smoking may affect the effectiveness of these treatment modalities.

Successful treatment of pustulotic arthro‐osteitis with amoxicillin: A case report and review of the literature

“…To investigate the efficacy of antibiotics for PPP and SAPHO syndrome, we conducted a literature review on PubMed of clinical cases that received antibiotics for PAO and SAPHO syndrome with detailed patient information using the search terms "pustulotic arthro-osteitis", "SAPHO syndrome", and "antibiotics". We show 30 cases, including our case, in Table 1 [4][5][6][7][8][9][10][11][12][13] The patients' median (range) age was 44.5 (15-72) years. There were nine male patients and 21 female patients.…”

Pro and contra: is synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) a spondyloarthritis variant?

“…Since C. acnes may trigger of SAPHO syndrome, antimicrobial therapy (mainly macrolides and tetracyclines) can sometimes be administered, especially in Japan [8 ▪ ,17,70–72]. In addition to direct antimicrobial effects, the anti-inflammatory and immunomodulatory impact of these agents have garnered increasing attention.…”

Anti-Inflammatory Effects of Potassium Iodide on SDS-Induced Murine Skin Inflammation

“…Murakami et al (2011) reported that patients with palmoplantar pustulosis -a common, chronic, and very refractory inflammatory skin disorder-had increased levels of IL-17erelated cytokines, such as TNF-a and IL-1b, in skin lesions and serum. Hayashi et al (2017) reported the success and effectiveness of KI in treating 25 cases of palmoplantar pustulosis; thus, we speculated that the anti-inflammatory effects of KI treatment are related to the regulation of these inflammatory cytokines. Accordingly, we studied the effect of KI specifically on neutrophils, M1 and M2 monocytes, CD4 þ and CD8 þ T cells, and regulatory T cells.…”

“…Potassium iodide (KI), originally derived from seaweed in the early 19th century, was initially used to treat thyroid disorders. However, KI is most useful in the dermatological field for treating cutaneous sporotrichosis and erythema nodosum (Hayashi et al, 2017). In addition, KI is reportedly useful in treating several noninfectious inflammatory skin disorders, such as palmoplantar pustulosis, cutaneous manifestations of Behçet disease, Sweet syndrome, and pyoderma gangrenosum (Costa et al, 2013;Hayashi et al, 2017;Sterling and Heymann, 2000).…”