Anti-Inflammatory Effects of Potassium Iodide on SDS-Induced Murine Skin Inflammation

Hayashi, Shujiro; Ishikawa, Satoko; Ishii, Eisuke; Koike, Masami; Kaminaga, Tomoko; Hamasaki, Yoichiro; Sairenchi, Toshimi; Kobashi, Gén; Igawa, Ken

doi:10.1016/j.jid.2020.01.028

Cited by 10 publications

(5 citation statements)

References 20 publications

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“… 85 , 86 The anti-inflammatory effect in vivo seems to be related to cytokine regulation, with increased levels of IL-10 and IL-35. 87 It is likely that the anti-inflammatory and immunomodulatory effects are responsible for faster clinical improvement than with itraconazole or terbinafine.…”

Section: Resultsmentioning

confidence: 99%

Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management

Orofino-Costa

Freitas²,

Bernardes-Engemann

et al. 2022

Anais Brasileiros de Dermatologia

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Section: Resultsmentioning

confidence: 99%

Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management

Orofino-Costa

Freitas²,

Bernardes-Engemann

et al. 2022

Anais Brasileiros de Dermatologia

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“…While a direct antimicrobial effect seems unlikely, immune-related effects are more wellaccepted but still controversial [63,64]. A shortened time to remission of all clinical signs in cats treated with the combined therapy may be related to the anti-inflammatory effect of KI linked to cytokine regulation [65], and/or to a beneficial interaction between ITZ and KI that has not been fully elucidated yet. In addition, excessive iodine supplementation in humans, as well as in cats, may affect the thyroid function, which might have an impact on the host immune response, but this has not been explored with the use of KI in the treatment of sporotrichosis [66][67][68][69][70][71].…”

Section: Discussionmentioning

confidence: 99%

A Randomized Clinical Trial Comparing Itraconazole and a Combination Therapy with Itraconazole and Potassium Iodide for the Treatment of Feline Sporotrichosis

Reis,

Pereira,

Miranda

et al. 2024

JoF

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Feline sporotrichosis is an endemic disease with high occurrence in Brazil. Itraconazole (ITZ) remains the drug of choice for treating this disease in cats, despite the increasing reports of therapeutic failure. A controlled, randomized clinical trial was performed on 166 naive cats with sporotrichosis to assess the effectiveness and safety of the combination therapy with ITZ and potassium iodide (KI) compared with ITZ monotherapy. Cats were randomly allocated into two treatment groups: G1—ITZ 100 mg/cat/day—and G2—ITZ 100 mg/cat/day + KI 2.5–20 mg/kg/day. Cats treated in G2 presented 77% more risk of reaching a clinical cure (a positive effect) than those treated in G1, even when controlled by negative predictors. The survival curves of the two treatment protocols indicate that a clinical cure was achieved faster in G2. An increase in the KI dose was necessary in 28 cats due to the persistence of clinical signs. Adverse reactions were equally frequent in both groups and manageable with a temporary drug suspension and/or a hepatoprotective therapy. The combination therapy was associated with a higher cure rate and a shorter treatment time, suggesting that ITZ+KI arises as a better option for treating feline sporotrichosis and should be considered the first-line treatment, especially in the presence of negative predictors.

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“…Despite diverse etiologies, the cellular and molecular pathomechanisms underlying panniculitis remain poorly characterized. Therapeutic approaches remain widely nonspecific, including non-steroidal anti-inflammatory drugs, oral potassium iodide, dapsone, and hydroxychloroquine (137)(138)(139)(140)(141).…”

Section: Sat In Inflammatory Skin Diseasesmentioning

confidence: 99%

Subcutaneous Adipose Tissue: Implications in Dermatological Diseases and Beyond

Ziadlou,

Pandian,

Hafner

et al. 2024

Preprint

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Subcutaneous adipose tissue (SAT) is the deepest component of the three-layered cutaneous integument. While mesenteric adipose tissue-based immune processes have gained recognition in the context of the metabolic syndrome, SAT has been traditionally considered primarily for energy storage, with less attention to its immune functions. SAT harbors a reservoir of immune and stromal cells that significantly impact metabolic and immunologic processes not only in the skin, but even on a systemic level. These processes include wound healing, cutaneous and systemic infections, immunometabolic and autoimmune diseases, inflammatory skin diseases, as well as neoplastic conditions. A better understanding of SAT immune functions in different processes, could open avenues for novel therapeutic interventions. Targeting SAT may not only address SAT-specific diseases but also offer potential treatments for cutaneous or even systemic conditions. This review aims to provide a comprehensive overview on SAT’s structure and functions, highlight recent advancements in understanding its role in both homeostatic and pathological conditions within and beyond the skin, and discuss the main questions for future research in the field.

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Anti-Inflammatory Effects of Potassium Iodide on SDS-Induced Murine Skin Inflammation

Cited by 10 publications

References 20 publications

Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management

Human sporotrichosis: recommendations from the Brazilian Society of Dermatology for the clinical, diagnostic and therapeutic management

A Randomized Clinical Trial Comparing Itraconazole and a Combination Therapy with Itraconazole and Potassium Iodide for the Treatment of Feline Sporotrichosis

Subcutaneous Adipose Tissue: Implications in Dermatological Diseases and Beyond

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