Successful treatment of pustulotic arthro‐osteitis with amoxicillin: A case report and review of the literature

Abstract

Palmoplantar pustulosis (PPP) is a chronic skin inflammatory disease characterized by sterile pustules on the palms and soles. Pustulotic arthro‐osteitis (PAO) is a major comorbidity of PPP, frequently affecting the anterior chest wall. PPP and PAO are thought to be closely associated with focal infection. We report a female in her 40s who developed pustules on her palms and soles with tenderness of both sternoclavicular and left sacroiliac joints, which were not improved with non‐steroidal anti‐inflammatory drugs. Of note, she showed a great response to amoxicillin, resulting in the almost complete resolution of her skin lesions and arthralgia. We also reviewed previous reports to learn more about the potential therapeutic options of antibiotics for PAO.

Spesolimab: Is it a new treatment target in palmoplantar pustulosis?

“…13 Practicing tonsillectomy and using antibiotics can help to alleviate skin lesions. [14][15][16] However, GPP associated with the infection is seldom to be seen and is predominantly characterized by innate immune inflammation and excessive neutrophil infiltration. 17 Moreover, IL36RN mutations among patients with PPP are at a very low frequency despite the strong correlation with GPP.…”

Antibiotics in SAPHO syndrome: Comment on the article by Terui et al.

“…None declared. Matteo Colina 1,2 Micheline Khodeir 3 1 Rheumatology Service, Section of Internal Medicine,…”

Infection in SAPHO syndrome: Is it a reactive osteitis?

“…Meanwhile, tonsillar epithelial crypt cells in patients with PPP secrete large amounts of IL‐6, which triggers osteoclast differentiation and bone resorption 18,19 . Antibiotics such as doxycycline, minocycline, amoxicillin, and others are effective in treatment 20 . In addition, practicing tonsillectomy is a good way to improve or even completely relieve skin or bone lesions, 21 not only in PPP patients, but also in SAPHO syndrome patients 22 .…”