Antibiotics in SAPHO syndrome: Comment on the article by Terui et al.

Colina, Matteo; Khodeir, Micheline

doi:10.1111/1346-8138.16937

Cited by 2 publications

(1 citation statement)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The etiopathogenesis is multifactorial, [2][3][4] resulting from the interaction between immune dysregulation and genetic and environmental factors. 3,5 The detection of Propionibacterium acnes in bone lesions of SAPHO highlighted the contribution of infectious agents in this syndrome.…”

Section: Highlightsmentioning

confidence: 99%

Pharmacological Management of Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome Syndrome

Slouma

Bettaieb²,

Rahmouni³

et al. 2021

J Clin Rheumatol

View full text Add to dashboard Cite

Synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome is a rare chronic disease with marked clinical and radiological heterogeneity. It is characterized by a combination of dermatological and osteoarticular manifestations. The treatment of SAPHO syndrome is not yet codified. It includes several therapeutic options such as anti-inflammatory drugs, bisphosphonates, antibiotics, conventional disease-modifying antirheumatic drugs, and biological treatment.This article aims to provide an updated review of the different pharmacological options for SAPHO syndrome. We also propose a therapeutic algorithm for the management of this disease.

show abstract

Section: Highlightsmentioning

confidence: 99%

Pharmacological Management of Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome Syndrome

Slouma

Bettaieb²,

Rahmouni³

et al. 2021

J Clin Rheumatol

View full text Add to dashboard Cite

show abstract

Author reply to antibiotics in SAPHO syndrome

Terui,

Segawa,

Otake

et al. 2023

The Journal of Dermatology

View full text Add to dashboard Cite

Since some doctors are skeptical about the effectiveness of antibiotics for pustulotic arthro-osteitis (PAO)/synovitis, acne, pustulosis, and hyperostosis syndrome (SAPHO), we are pleased that Colina et al.agreed with our opinion of the usefulness of antibiotic treatment for PAO/SAPHO and the necessity of prospective studies to further insights. 2 As you noted, the case in our article also impressed us because of the efficacy of antibiotic treatment in polyostotic disease involvement. This is one of the reasons why we conducted the previous literature review to determine the antibiotic efficacy. As we described in our article, most of the cases showed monostotic involvement, and there were some cases with polyostotic involvement that improved with antibiotic treatment. In this study, we tried to explore the characteristics that differentiate monostotic involvement from polyostotic involvement. However, we could not see any difference, at least in the 30 cases in the article, possibly because of the lack of information for each case and the number of cases. It will be necessary to conduct large-scale prospective studies to gain a deeper understanding of the pathomechanisms and clinical characteristics of PAO/SAPHO.

show abstract

Antibiotics in SAPHO syndrome: Comment on the article by Terui et al.

Cited by 2 publications

References 6 publications

Pharmacological Management of Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome Syndrome

Pharmacological Management of Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome Syndrome

Author reply to antibiotics in SAPHO syndrome

Contact Info

Product

Resources

About