Palladium-catalyzed selective synthesis of 3,4-dihydroquinazolines from electron-rich arylamines, electron-poor arylamines and glyoxalates

Abstract

A simple palladium-catalyzed selective synthesis of structurally diverse 3,4-dihydroquinazolines from electron-rich arylamines, electron-poor arylamines and glyoxalates has been developed under mild conditions. This reaction is carried out in a tandem manner constituted by the condensation of arylamines and glyoxalates, the selective Diels-Alder cycloaddition and oxidation processes, in which 4-nitrothiophenol was used as the key ligand.

Natural Deep Eutectic Solvent-Catalyzed Selenocyanation of Activated Alkynes via an Intermolecular H-Bonding Activation Process

“…As part of our ongoing research interest in the green synthesis, − we have reported the eco-friendly functionalization of alkynes. − In this paper, we report for the first time an economical and eco-friendly protocol for the synthesis of various Z -vinyl selenolates through natural DES (ChCl/glycolic acid) catalyzed selenocyanation of activated alkynes (Scheme c).…”

Clean Preparation of Quinolin-2-yl Substituted Ureas in Water

“…However, to the best of our knowledge, the preparation of quinolin-2-yl substituted ureas from readily available quinoline N -oxides has never been reported. In continuation of our research program in green and sustainable chemistry, − we have reported the ecofriendly preparation of N -heterocycles and their derivatives. − In this paper, we report an environmentally friendly method for the clean preparation of quinolin-2-yl substituted ureas from readily available quinoline N -oxides and carbodiimides in water (Scheme d).…”

Practical Approach for Clean Preparation of Z-β-Thiocyanate Alkenyl Esters

“…In continuation of our studies in sustainable chemistry, − herein we report a clean and practical strategy for the preparation of a variety of Z-β-thiocyanate alkenyl esters. The ecofriendly lactic acid plays a dual function in the quantitative transformation, serving as a recyclable catalyst and reaction medium.…”