Paget's disease of the vulva: Diagnosis and follow-up key to management; A retrospective study of 50 cases from Queensland

Jones, Ian S.; Crandon, Alex J.; Sanday, Karen

doi:10.1016/j.ygyno.2011.03.033

Cited by 51 publications

(40 citation statements)

References 9 publications

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“…The incidence of genital extramammary Paget's disease in this study is consistent with the literature [18]. The disease lesions confined to the epidermis had better prognosis [19]. In research it is still controversial about the margin on the pathological type of operation.…”

Section: Lymph Node Status Totalsupporting

confidence: 91%

Clinical analysis of vulvar carcinoma

Thakur¹,

Nijamudin²,

Hua³

et al. 2013

Gynecol

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Objective: The purpose of this study is to understand the incidence, related factors, and the prognosis factors in order to avoid risk, proper method of diagnosis and treatment and reduce complications and provide the basis. Methods: 85 Vulvar cancer (VC) patients treated in our hospital from 2002.10 to 2012.10 were collected and analyzed by retrospective comparative methods. SPSS19.0 application software was used for the statistical analysis. The clinical data are analyzed by chi-square and F test statistic methods. P < 0.05 was a significant difference between the judgment standard. Results: During 10 years, we treated 3391 cases of the primary malignant tumors including 85 VC cases; VC was 2.89% (85/3391). The age was between 24~88 years old, mean was 57.09±12.93 yrs. old, variable age (F=6. 013, P=0.016<0.05). VC had seen more in rural than urban patients. By statistical analysis, region distribution in these two groups was remarkably different=4.16, P=0.045<0.05, but the urban proportion of patients in different years has no difference (χ2=0.080, P=0.777). Conclusion:The number of cases increased progressively in young age. VC patients were more in rural area than urban. High-risk groups Suggested doing regular physical exam. For long-term genital itching, genital tumor, genital ulcers, and other symptoms, should be alert to the possibility of VC. Preoperative diagnosis should be Colposcopic, biopsy in order to improve the accuracy of earlier diagnosis. Postoperative common complications are wound infection. Follow-up rate is low; It is difficult to say statistically survival rate is 5 years.

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Section: Lymph Node Status Totalsupporting

confidence: 91%

Clinical analysis of vulvar carcinoma

Thakur¹,

Nijamudin²,

Hua³

et al. 2013

Gynecol

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“…In 2011, Jones et al (Jones et al, 2011) performed a retrospective study of 50 cases from Queensland, Australia reviewing the clinical features, diagnosis, management, and outcomes of women treated for Paget's disease of the vulva. The study determined that of the 12 patients who died, two died of Paget's disease both of which had widespread disease at the time of death.…”

Section: Discussionmentioning

confidence: 99%

Paget's disease of the vulva: A review of 89 cases

Onaiwu

Salcedo²,

Pessini³

et al. 2017

Gynecologic Oncology Reports

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The purpose of this study was to retrospectively review the clinical characteristics and outcomes of a series of women with Paget's disease of the vulva. A retrospective review was performed of 89 women with Paget's disease of the vulva evaluated at a single institution between 1966 and 2010. Medical records were reviewed for demographic information, clinical data, pathologic findings, treatment modalities and outcomes. We found that the primary treatment was surgery for 74 (83.1%) patients, with positive margins noted in 70.1% of cases. Five patients (5.6%) underwent topical treatment with imiquimod and/or 5-fluorouracil, one patient (1.1%) underwent laser ablation and treatment was unknown in 9 patients (10.1%). The majority of patients had multiple recurrences, with 18% having four or more recurrences. There were no significant differences in recurrence rates between patients who underwent surgery and those who did not. Furthermore, there was no association between positive margins following primary surgery and recurrence. Forty-one patients (46.1%) were diagnosed with 53 synchronous or metachronous cancers. Seven patients (7.9%) were found to have invasive vulvar cancer with 1 mm or more depth of invasion, but none of the patients died of Paget's disease or associated vulvar/vaginal cancer. Our findings suggest that the majority of patients with Paget's disease of the vulva develop multiple recurrences regardless of treatment modality or margin status. Alternatives to surgery are needed to better care for women with this disease.

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“…Noninvasive EMPD has an excellent prognosis. 125 The frequency of invasion in EMPD was reported as 0% to 48% of cases in one large meta-analysis. 126 Kodama et al 127 reported 30% (9 of their 30 cases) had invasion, similar to 29% (14 of 49 cases) observed in our series, whereas Shaco-Levy et al 124 reported 18% in their series (10 of 56 cases).…”

Section: 100mentioning

confidence: 99%

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

Baker

Selim

Hoang

2013

Archives of Pathology &Amp; Laboratory Medicine

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Context.-Because the skin and modified mucosal surfaces of the vulvar region contain dense apocrine glands and anogenital mammary-like glands, in addition to eccrine glands and folliculosebaceous units, benign as well as malignant lesions derived from these adnexal structures are, not surprisingly, found in the vulva. However, their incidence occurring in the vulva has not been reported, to our knowledge.Objective.-To determine the incidence of various vulvar adnexal lesions.Design.-We performed a retrospective review of the cases at our institution.Results.-A total of 189 vulvar adnexal lesions were identified. Most of these lesions were benign (133 of 189; 70%), with hidradenoma papilliferum being the most common, followed by syringoma and various types of cysts. Rare cases of tubular adenoma, poroma, spiradenoma, hidradenoma, cylindroma, sebaceoma, and trichoepithelioma were identified. Malignant adnexal neoplasms comprised the remaining 30% (56 of 189) of the cases. Extramammary Paget disease was the most common (49 of 56), and 29% (14 of 49) demonstrated an invasive component. Rare cases of basal cell carcinoma, sebaceous carcinoma, apocrine carcinoma, adenoid cystic carcinoma, and spiradenocarcinoma were identified.Conclusions.-In this retrospective review, we identified several benign entities that have not been previously reported on the vulva, namely pilomatricoma, poroma, spiradenoma, and sebaceoma. Hidradenoma papilliferum and extramammary Paget disease were the most common benign and malignant adnexal neoplasms, respectively. The spectrum of various vulvar adnexal lesions appears to reflect the frequency of the underlying glandular elements.

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Paget's disease of the vulva: Diagnosis and follow-up key to management; A retrospective study of 50 cases from Queensland

Cited by 51 publications

References 9 publications

Clinical analysis of vulvar carcinoma

Clinical analysis of vulvar carcinoma

Paget's disease of the vulva: A review of 89 cases

Vulvar Adnexal Lesions: A 32-Year, Single-Institution Review From Massachusetts General Hospital

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