Paeciloquinones A,B,C,D,E and F: New Potent Inhibitors of Protein Tyrosine Kinase Produced by Paecilomyces carneus. II. Characterization and Structure Determination.

Fredenhagen, Andreas; Hug, P.; Sauter, Hanspeter; Peter, Heinrich H.

doi:10.7164/antibiotics.48.199

Cited by 25 publications

(7 citation statements)

References 21 publications

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“…29 But none of its species was found to produce cyclohexenones so far except in our present study on Paecilomyces liacinus. These cyclohexenones have been previously reported only from fungal genera Phoma and Alternaria, both of which belong to the family Pleosporaceae (order Pleosporales) while the genus Paecilomyces belong to the family Trichocomaceae (order Eurotiales).…”

Section: Resultsmentioning

confidence: 49%

α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

Elbandy¹,

Shinde²,

Hong³

et al. 2009

Bulletin of the Korean Chemical Society

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New α-pyrones (1 and 2) and cyclohexenones (13 and 14) were isolated along with known analogues (3, 5−12) from the ethyl acetate extract of the whole broth of the fungus Paecilomyces lilacinus, a strain derived from a marine sponge Petrosia sp. Their structures were established by interpretation of 1D and 2D NMR, and FABMS data. It is interesting to isolate cyclohexenone derivatives from the genus Paecilomyces (family Trichocomaceae, order Eurotiales), since these cyclohexenones were previously reported only from far distinct genera, Phoma and Alternaria (family Pleosporaceae, order Pleosporales). Compounds 6, 7, and 9 were evaluated for cytotoxicity against a small panel of human solid tumor cell lines. Their cytotoxicity was insignificant upto a concentration of 30 µg/mL.

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Section: Resultsmentioning

confidence: 49%

α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

Elbandy¹,

Shinde²,

Hong³

et al. 2009

Bulletin of the Korean Chemical Society

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“…Paecilomyces is a ubiquitous saprophytic soil mold that is rarely pathogenic to humans or animals 1 . Paecilomyces is commonly involved in food spoilage and has been the subject of investigation for antibiotic development 2–4 and insect control 5,6 . In human beings, most infections are associated with prosthesis implants or immunosup‐pression 1 .…”

Section: Discussionmentioning

confidence: 99%

Pleural Effusion in a Dog With Discospondylitis

Quance-Fitch

Schachter

Christopher

2002

Veterinary Clinical Pathol

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A 7-year-old, 28-kg spayed female mixed-breed dog was presented to the Veterinary Medical Teaching Hospital (VMTH) at the University of California, Davis for evaluation of lethargy and weight loss of 6 months duration. The dog had been diagnosed with discospondylitis, spondylosis, and hilar lymphadenopathy by the referring veterinarian 2 months previously. A course of antibiotics failed to alleviate clinical signs. On physical examination at the VMTH the dog was moderately cachectic with muscle atrophy, had severe paraspinal pain from the cervical to midlumbar spine, and had decreased lateral range of motion in its neck. Crepitus was present over several joints and joint capsules were thickened. Ventral lung sounds were decreased and a slightly increased inspiratory effort was noted. Prescapular and popliteal lymph nodes were mildly enlarged. Areas of retinal hemorrhage and chorioretinitis were noted bilaterally on fundic exam. Radiographs confirmed progressive lumbar endplate lysis compatible with discospondylitis, mild to moderate pleural effusion, hilar lymphadenopathy, and moderate thoracolumbar spondylosis. Abdominal ultrasound revealed hepatosplenomegaly with echogenicity changes and diffuse abdominal lymphadenopathy.Results of a CBC revealed mild nonregenerative anemia (HCT 26.1%, reference interval 37%-55%; reticulocytes 59,840/µL, reference value >60,000/µL if anemic), mild lymphopenia (651/µL, reference interval 1000-4800/µL), and moderate thrombocytopenia (78,000/µL, reference interval 200,000-500,000/µL). Results of a chemistry profile revealed hypocalcemia (8.9 mg/dL, reference interval 9.9-11.4 mg/dL), marked hypoalbuminemia (1.0 mg/dL, reference interval 2.9-4.2 mg/dL), marked hyperglobulinemia (9.7 mg/dL, reference interval 2.3-4.2 mg/dL), moderately increased alkaline phosphatase activity (495 U/L, reference interval 15-127 U/L), and a mild increase in gamma-glutamyltransferase activity (13 U/L, reference interval 0-6 U/L). Moderate proteinuria was noted, with a urine protein:creatinine ratio of 1.72. Pleural fluid was hazy orange with a clear Vol. 31 / No. 2 / 2002 Veterinary Clinical Pathology Figure 3. Fine-needle aspirate of spleen from a dog with disseminated Pacilomyces infection. Pyogranulomatous inflammation and numerous fungal elements are seen. Wright-Giemsa, bar=10 µm.Figure 4. Fine-needle aspirate of lymph node showing pyogranulomatous inflammation and periodic acid-Schiff (PAS)-positive fungal elements. PAS, bar=10 µm. Vol. 31 / No. 2 / 2002 Veterinary Clinical Pathology Page 71Quance-Fitch, Schachter, Christopher toruloid hyphae resembling pseudohyphae, and unicellular conidia arising from phialides. The eosinophilic component of the inflammation in the pleural fluid was also of interest. Eosinophilia in fluid has been associated with fungal infections, neoplasia (including mast cell tumors, lymphoma, and thymoma), heartworm disease, allergic conditions, and hypersensitivity reactions. With the combination of other clinical findings in this dog, a high degree of suspicion existed fo...

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“…Rhodocladonic acid was identified in lichen Cladonia sp. [8]; it is also the intermediate of synthetic product [9], i.e., paeciloquinone C. This compound, the common anthraquinone structurally comparable to our monomer compound, was also isolated from fungus Paecilomyces carneus [10]. Further anthraquinones with unusual isoprenyl (geranyl) chain(s) were isolated and identified in different plants [11] or synthesized [12,13].…”

Section: Introductionmentioning

confidence: 89%

The colleflaccinosides, two chiral bianthraquinone glycosides with antitumor activity from the lichen Collema flaccidum collected in Israel and Russia

Řezanka

Dembitsky

2006

Natural Product Research

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Colleflaccinosides A and B, two chiral bianthraquinone glycosides from the two geographical varieties of lichen Collema flaccidum collected in Russia and Israel have been isolated as new natural products. Their structures were elucidated using UV, CD, IR, MS, 1D and 2D NMR spectral data, and chemical degradation. The colleflaccinosides B had significant antitumor activity in the crown gall tumor inhibition test.

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Paeciloquinones A,B,C,D,E and F: New Potent Inhibitors of Protein Tyrosine Kinase Produced by Paecilomyces carneus. II. Characterization and Structure Determination.

Cited by 25 publications

References 21 publications

α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

Pleural Effusion in a Dog With Discospondylitis

The colleflaccinosides, two chiral bianthraquinone glycosides with antitumor activity from the lichen Collema flaccidum collected in Israel and Russia

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