α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

Elbandy, Mohamed; Shinde, Pramod B.; Hong, Jongki; Bae, Kyung Sook; Kim, Mi Ae; Lee, Sang Mong; Jung, Jee H.

doi:10.5012/bkcs.2009.30.1.188

Cited by 42 publications

(4 citation statements)

References 27 publications

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“…Other metabolites such as phomapyrone C also showed antibacteria activity against Acinetobacter baumannii, and 1,2-dilinolylglycero-O-4'-(N,N,N-trimethyl)homoserine, methyl myristate and cerebroside B-D inhibited the human cancer K562, MCF-7, HL-60, and BGC-823 cell lines. Purpureocillium lilacinum also reported to produce a pyridone alkaloid, paecilomide as acetylcholine esterase inhibitor, and cerebrosides A showed nematicidal activity against Bursaphelenchus xylophilus (Arai et al 1973;Fukushima et al 1983;Elbandy et al 2009;Yang et al 2011;Cui et al 2013;Teles and Takahashi 2013). The present study is the first report of P. lilacinum marine fungus associated sponge showing inhibitory effects on pancreatic lipase enzyme activity.…”

Section: Discussionsupporting

confidence: 57%

In Vitro Pancreatic Lipase Inhibition by Marine Fungi Purpureocillium lilacinum Associated with Stylissa sp. Sponge as Anti-obesity Agent

et al. 2021

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This study aimed to evaluate the potential of marine fungus Purpureocillium lilacinum isolated from an Indonesian marine sponge Stylissa sp. as an anti-obesity agent through pancreatic lipase inhibition assay. The fungus was identified as P. lilacinum through morphological and molecular characteristics. The fungal extract’s inhibition activity and kinetics were evaluated using spectrophotometry and Lineweaver-Burk plots. Ethyl acetate and butanol were used for extraction. Both extracts showed pancreatic lipase inhibition in a concentration-dependent manner. Both crude extracts were then fractionated once. All fractionated extracts showed inhibitory activity above 50%, with the highest activity found in fraction 5 of ethyl acetate at 93.41% inhibition. The best fractionated extract had an IC50value of 220.60 µg.mL-1. The most active fraction of P. lilacinum had a competitive-type inhibitor behavior as shown by the value of Vmax not significantly changing from 388.80 to 382.62 mM pNP.min-1, and the Michaelis-Menten constant (KM) increased from 2.02 to 5.47 mM in the presence of 500 µg.mL-1 fractionated extract. Metabolite identification with LC-MS/MS QTOF suggested that galangin, kaempferol, and quercetin were responsible for the observed lipase inhibition.

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Section: Discussionsupporting

confidence: 57%

In Vitro Pancreatic Lipase Inhibition by Marine Fungi Purpureocillium lilacinum Associated with Stylissa sp. Sponge as Anti-obesity Agent

et al. 2021

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“…In recent years, a series of a-pyrones have been reported from the fungi, including Paecilomyces sp. [16], Penicillium sp. [17], Aspergillus sp.…”

Section: Resultsmentioning

confidence: 99%

New α-pyrone and phthalide from the Xylariaceae fungus

Zou

Zhao

et al. 2015

Journal of Asian Natural Products Research

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A new α-pyrone xylaripyrone A (1) and a new phthalide xylariphthalide A (2) were isolated from the Xylariaceae fungus (no. 63-19-7-3), along with four related known phthalides (3-6): 4-[(acetyloxy)methyl]-7-methoxy-6-methyl-1(3H)-isobenzofuranone (3), convolvulol (4), 7-methoxy-4,6-dimethyl-3H-isobenzofuran-1-one (5), and convolvulanic acid B (6). Their structures were determined on the basis of IR, MS, and NMR spectroscopic analyses.

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“…Carotenoids are the most common types of pigments found in marine environments. In general, these pigments are biosynthesized by all autotrophic marine organisms, including fungi, algae, archaea, and bacteria [70,164].…”

Section: Pigmentsmentioning

confidence: 99%

Anti-Inflammatory Effects of Marine Bioactive Compounds and Their Potential as Functional Food Ingredients in the Prevention and Treatment of Neuroinflammatory Disorders

Elbandy

2022

Molecules

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Functional foods include enhanced, enriched, fortified, or whole foods that impart health benefits beyond their nutritional value, particularly when consumed as part of a varied diet on a regular basis at effective levels. Marine sources can serve as the sources of various healthy foods and numerous functional food ingredients with biological effects can be derived from these sources. Microalgae, macroalgae, crustaceans, fungi, bacteria fish, and fish by-products are the most common marine sources that can provide many potential functional food ingredients including phenolic compounds, proteins and peptides, and polysaccharides. Neuroinflammation is closely linked with the initiation and progression of various neurodegenerative diseases, including Alzheimer’s disease, Huntington’s disease, and Parkinson’s disease. Activation of astrocytes and microglia is a defense mechanism of the brain to counter damaged tissues and detrimental pathogens, wherein their chronic activation triggers neuroinflammation that can further exacerbate or induce neurodegeneration. Currently, available therapeutic agents only provide symptomatic relief from these disorders and no therapies are available to stop or slow down the advancement of neurodegeneration. Thereffore, natural compounds that can exert a protective effect against these disorders have therapeutic potential. Numerous chemical compounds, including bioactive peptides, fatty acids, pigments, alkaloids, and polysaccharides, have already been isolated from marine sources that show anti-inflammatory properties, which can be effective in the treatment and prevention of neuroinflammatory disorders. The anti-inflammatory potential of marine-derived compounds as functional food ingredients in the prevention and treatment of neurological disorders is covered in this review.

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α-Pyrones and Yellow Pigments from the Sponge-Derived Fungus Paecilomyces lilacinus

Cited by 42 publications

References 27 publications

In Vitro Pancreatic Lipase Inhibition by Marine Fungi Purpureocillium lilacinum Associated with Stylissa sp. Sponge as Anti-obesity Agent

In Vitro Pancreatic Lipase Inhibition by Marine Fungi Purpureocillium lilacinum Associated with Stylissa sp. Sponge as Anti-obesity Agent

New α-pyrone and phthalide from the Xylariaceae fungus

Anti-Inflammatory Effects of Marine Bioactive Compounds and Their Potential as Functional Food Ingredients in the Prevention and Treatment of Neuroinflammatory Disorders

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