Paclitaxel Delivery Using Carrier made from Curcumin Derivative: Synergism Between Carrier and the Loaded Drug for Effective Cancer Treatment

Defect-related luminescent nanostructured hydroxyapatite promotes mineralization through both intracellular and extracellular pathways

“…The uptake of S2 was performed according to the method described by Amornwachirabodee et al 14 In brief, OBs were seeded in a 35 mm glass bottom dish at the density of 4 × 10 4 cells per well and allowed to adhere overnight. Cells were incubated with S2 at 37 °C under a humidified atmosphere with 5% CO 2 for 24 h. The media were removed, and the cells were washed thrice with PBS; then, the cells were stained with 6 μg mL −1 acridine orange (AO) for 30 min in the dark.…”

Water-dispersible unadulterated α-mangostin particles for biomedical applications

“…Assemblies into water-dispersible nano-aggregates of conjugates of hydrophobic drug molecules containing hydrophilic oligomers, or complexes between hydrophilic peptide and small hydrophobic drug molecules have been reported in the past decades [31][32][33][34]. Those assemblies were predictable as the drug conjugate structures resemble the surfactant molecules with the hydrophobic head (drug molecule) and hydrophilic tail parts (auxiliaries).…”

“…We have noticed that the strategic mechanism commonly used to induce these assemblies is the staggering of aromatic rings, i.e. drug molecules reported capable of assembling into such particles usually possess an aromatic ring system [31][32][33][34][35][36][37][38][39][40][41][42][43].…”

Nanocarrier with Self-Antioxidative Property for Stabilizing and Delivering Ascorbyl Palmitate into Skin

“…So far, only a few bioactive carriers have been reported, which include liposomes made from ascorbyl palmitate (AP), 1 nanocarriers with UV absorptive properties, 2,3 delivery systems made from L-ascorbic (vitamin C) derivatives, 4,5 and carriers with anticancer activity. 6 Furthermore, UV absorptive carriers have been shown to slowly release fragrance molecules and at the same time act as an UV screening material for the skin. 3 Carriers with anticancer activity that showed good antitumor activity on their own were reported to work synergistically with their payload to combat the drug resistant cancerous cells.…”

“…3 Carriers with anticancer activity that showed good antitumor activity on their own were reported to work synergistically with their payload to combat the drug resistant cancerous cells. 6 There are many labile bioactive molecules that need a better technology to keep their chemical structure unchanged during storage and/or during their transport to the required target site in the body. As the most common cause of the deterioration of active molecules is oxidation, usually, through free radical mechanisms initiated by reactive oxygen species, we expect that a carrier system with an integral free radical scavenging activity will be able to lessen such deterioration and so increase the stability of their otherwise oxidation-sensitive payloads.…”