Nanocarrier with Self-Antioxidative Property for Stabilizing and Delivering Ascorbyl Palmitate into Skin

Janesirisakule, Sirinapa; Sinthusake, Tarit; Wanichwecharungruang, Supason

doi:10.1002/jps.23641

Cited by 17 publications

(9 citation statements)

References 29 publications

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“…A β-cyclodextrin-curcumin nanoparticle complex improved permeability across skin model tissue in gel form 1.8-fold over the free CUR gel (120). Another curcumin encapsulated in PVA nanoformulation showed no improved penetration in pig skin dermis via hair follicle (121). Ethyl cellulose and methylcellulose blended curcumin nanoparticles can be used to transport curcumin effectively into the porcine ear skin (122).…”

Section: Skin Diseasesmentioning

confidence: 99%

Therapeutic Applications of Curcumin Nanoformulations

Yallapu

Nagesh

Jaggi

et al. 2015

AAPS J

301

177

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Abstract. Curcumin (diferuloylmethane) is a bioactive and major phenolic component of turmeric derived from the rhizomes of curcuma longa linn. For centuries, curcumin has exhibited excellent therapeutic benefits in various diseases. Owing to its anti-oxidant and anti-inflammatory properties, curcumin plays a significant beneficial and pleiotropic regulatory role in various pathological conditions including cancer, cardiovascular disease, Alzheimer's disease, inflammatory disorders, neurological disorders, and so on. Despite such phenomenal advances in medicinal applications, the clinical implication of native curcumin is hindered due to low solubility, physico-chemical instability, poor bioavailability, rapid metabolism, and poor pharmacokinetics. However, these issues can be overcome by utilizing an efficient delivery system. Active scientific research was initiated in 2005 to improve curcumin's pharmacokinetics, systemic bioavailability, and biological activity by encapsulating or by loading curcumin into nanoform(s) (nanoformulations). A significant number of nanoformulations exist that can be translated toward medicinal use upon successful completion of pre-clinical and human clinical trials. Considering this perspective, current review provides an overview of an efficient curcumin nanoformulation for a targeted therapeutic option for various human diseases. In this review article, we discuss the clinical evidence, current status, and future opportunities of curcumin nanoformulation(s) in the field of medicine. In addition, this review presents a concise summary of the actions required to develop curcumin nanoformulations as pharmaceutical or nutraceutical candidates.

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Section: Skin Diseasesmentioning

confidence: 99%

Therapeutic Applications of Curcumin Nanoformulations

Yallapu

Nagesh

Jaggi

et al. 2015

AAPS J

301

177

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“…Polymeric NPs are usually found to accumulate in the hair follicles that act as a long term reservoir to release drugs in the stratum corneum . Curcumin encapsulated with poly(vinyl alcohol) polymers was shown to penetrate deep into the hair follicles of pig skin [194]. Chitosan-coated PLGA NPs have also been used for the transfollicular delivery of ovalbumin (OVA) in pig skin [195].…”

Section: Penetration Of Nps Across Skinmentioning

confidence: 99%

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

2014

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Nanoparticles (NPs) have emerged as an effective modality for the treatment of various diseases including cancer, cardiovascular and inflammatory diseases. Various forms of NPs including liposomes, polymer particles, micelles, dendrimers, quantum dots, gold NPs and carbon nanotubes have been synthesized and tested for therapeutic applications. One of the greatest challenges that limit the success of NPs is their ability to reach the therapeutic site at necessary doses while minimizing accumulation at undesired sites. The biodistribution of NPs is determined by body’s biological barriers that manifest in several distinct ways. For intravascular delivery of NPs, the barrier manifests in the form of: (i) immune clearance in the liver and spleen, (ii) permeation across the endothelium into target tissues, (iii) penetration through the tissue interstitium, (iv) endocytosis in target cells, (v) diffusion through cytoplasm and (vi) eventually entry into the nucleus, if required. Certain applications of NPs also rely on delivery through alternate routes including skin and mucosal membranes of the nose, lungs, intestine and vagina. In these cases, the diffusive resistance of these tissues poses a significant barrier to delivery. This review focuses on the current understanding of penetration of NPs through biological barriers. Emphasis is placed on transport barriers and not immunological barriers. The review also discusses design strategies for overcoming the barrier properties.

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“…The obtained curcumin-grafted PV(OH) polymer (CURPV(OH)) was then fabricated into a nanocarrier and AP was encapsulated into the CUR-PV(OH) nanocarrier. The stability of the encapsulated AP was evaluated and it demonstrated better stability compared to free AP, as can be observed in Figure 3 [32].…”

Section: Nanocarriers For Vitamin Cmentioning

confidence: 92%

“…Stability of dry free AP (unencapsulated AP), or AP encapsulated in different nanocarriers, after storage at 30 °C under light-proof conditions with normal air exposure. Reproduced with permission from[32], published by Wiley Periodicals, Inc., 2013.…”

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confidence: 99%

Nanocarriers for Delivery of Antioxidants on the Skin

Vinardell

Mitjans

2015

Cosmetics

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Skin is protected from the harmful effects of free radicals by the presence of an endogenous antioxidant system. However, when exposed to ultraviolet (UV) radiation, there is an imbalance between pro-oxidants and antioxidants, leading to oxidative stress and photoaging of the skin. It has been described that free radicals and other reactive species can cause severe damage to cells and cell components of the skin, which results in skin aging and cancer. To prevent these actions on skin, the use of topical antioxidant supplementation is a strategy used in the cosmetics industry and these antioxidants act on quenching free radicals. There are many studies that demonstrated the antioxidant activity of many phytochemicals or bioactive compounds by free radical scavenging. However, many bioactive substances are unstable when exposed to light or lose activity during storage. The potential sensitivity of these substances to light exposure is of importance in cosmetic formulations applied to skin because photo-degradation might occur, reducing their activity. One strategy to reduce this effect on the skin is the preparation of different types of nanomaterials that allow the encapsulation of the antioxidant substances. Another problem related to some antioxidants is their inefficient percutaneous penetration, which limits the amount of the active ingredient able to reach the site of action in viable epidermis and dermis. In this sense, the encapsulation in polymeric nanoparticles could enhance the permeation of these substances. Nanocarriers offers several advantages over conventional passive delivery, such as increased surface area, higher solubility, improved stability, controlled release, reduced skin irritancy, and protection from degradation. The different nanocarrier systems used in cosmetics include nanolipid delivery systems such as solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), nanoemulsions OPEN ACCESS Cosmetics 2015, 2 343 (NEs), nanoparticles (NP) suspension, and polymer NPs, among others. In this review, we present the different types of nanomaterials used in cosmetic formulations to obtain the best effect of antioxidants applied onto the skin.

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Nanocarrier with Self-Antioxidative Property for Stabilizing and Delivering Ascorbyl Palmitate into Skin

Cited by 17 publications

References 29 publications

Therapeutic Applications of Curcumin Nanoformulations

Therapeutic Applications of Curcumin Nanoformulations

Challenges associated with penetration of nanoparticles across cell and tissue barriers: A review of current status and future prospects

Nanocarriers for Delivery of Antioxidants on the Skin

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