p53 Expression in Triple Negative Breast Carcinomas: Evidence of Age-Related and Racial Differences

Davion, Simone; Sullivan, Megan; Rohan, Stephen; Siziopikou, Kalliopi P.

doi:10.4236/jct.2012.325084

Cited by 3 publications

(3 citation statements)

References 27 publications

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“…The relationship between the expression of ER and PR, ER and HER2/neu, PR and HER2/neu, p53 and Ki-67, ER and Ki-67, PR and Ki-67 indicate the presence of close cooperation between the various links of IDC progression [ 10 , 30 ].…”

Section: Discussionmentioning

confidence: 99%

Heavy metals effect on breast cancer progression

Romaniuk

Lyndin

Sikora

et al. 2017

J Occup Med Toxicol

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BackgroundBreast cancer is the most frequent localization of malignant process in American women and women of European countries. To date it is not possible to control the morbidity growth due to lack of effective ways of primary prevention. Comparing the incidence of breast cancer in developed countries with the countries of Asia and Africa, there is the fact of population predominance lesion in more urbanized countries. This suggests that the environment along with other factors, occupies a significant place in the initiation and progression of breast neoplasia. The impressive rates of industrial development led to the pollution of soil, surface water and, as a consequence, food by heavy metal salts.The purposes of this paper are as follows: the chemical composition determination of neoplastic breast tissue, evaluation of the DNA methylation level, study of prognostic-important receptors expression in the breast cancer cells, establishing linkages between all the derived indicators.MethodsIn our study we used the following methods: studying of the chemical composition of breast cancer tissue by atomic absorption spectrophotometry and energy-dispersion spectrometer; іmmunohistochemical study of ER, PR, HER2/neu, p53, Ki-67, E-cadherin and MGMT receptors; DNA extraction and investigation by oscillating infrared spectroscopy method.ResultsThe total amount of heavy metals in breast cancer tissue ranged from 51.21 × 10−3 to 84.86 × 10−3 μg/kg. We have got the following results: the growth of heavy metals in neoplastic tissue is accompanied with the increase of HER2/neu, p53, Ki-67, MGMT expression and decrease of ER and PR expression. The increment of pathological DNA methylation is accompanied with the increasing amount of heavy metals in tumor tissue.ConclusionsHeavy metals through different pathogenetic links stimulate the progression of breast cancer and reduce its sensitivity to treatment. DNA of tumor tissue has a different level of methylation which changes with the amount of heavy metals in cancer cells. This is displayed on the synthesis of prognostically important receptors in neoplastic tissue.

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Section: Discussionmentioning

confidence: 99%

Heavy metals effect on breast cancer progression

Romaniuk

Lyndin

Sikora

et al. 2017

J Occup Med Toxicol

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“…This could be used for stratification of this heterogeneous subtype of breast cancers into subgroups according to prognosis and chemotherapeutic response (34). It was shown that p53 positivity in TNBC correlates with poor survival, worse response to therapy and is more common in younger patients (35, 36). Our study could not corroborate the usefulness of p53 expression as a prognostic biomarker for OS in TNBC patients.…”

Section: Discussionmentioning

confidence: 99%

Apoptosis regulator Bcl-2 is an independent prognostic marker for worse overall survival in triple-negative breast cancer patients

Ozretić

Alvir²,

Šarčević³

et al. 2017

Int J Biol Markers

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“…However, we suggest that there may be dysregulation up or downstream of these pathways as a result of a mutation, and the increase in activity of these pathways could be explained by the patient’s cells attempting to compensate for dysregulation. p53-expressing tumors are more frequent in AA women with TNBC when compared to their CA counterparts with TNBC [ 58 ], so the increase in expression of the p53 subnetwork could be partially explained by this fact.…”

Section: Discussionmentioning

confidence: 99%

Differentially Expressed Transcripts and Dysregulated Signaling Pathways and Networks in African American Breast Cancer

et al. 2013

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African Americans (AAs) have higher mortality rate from breast cancer than that of Caucasian Americans (CAs) even when socioeconomic factors are accounted for. To better understand the driving biological factors of this health disparity, we performed a comprehensive differential gene expression analysis, including subtype- and stage-specific analysis, using the breast cancer data in the Cancer Genome Atlas (TCGA). In total, 674 unique genes and other transcripts were found differentially expressed between these two populations. The numbers of differentially expressed genes between AA and CA patients increased in each stage of tumor progression: there were 26 in stage I, 161 in stage II, and 223 in stage III. Resistin, a gene that is linked to obesity, insulin resistance, and breast cancer, was expressed more than four times higher in AA tumors. An uncharacterized, long, non-coding RNA, LOC90784, was down-regulated in AA tumors, and its expression was inversely related to cancer stage and was the lowest in triple negative AA breast tumors. Network analysis showed increased expression of a majority of components in p53 and BRCA1 subnetworks in AA breast tumor samples, and members of the aurora B and polo-like kinase signaling pathways were also highly expressed. Higher gene expression diversity was observed in more advanced stage breast tumors suggesting increased genomic instability during tumor progression. Amplified resistin expression may indicate insulin-resistant type II diabetes and obesity are associated with AA breast cancer. Expression of LOC90784 may have a protective effect on breast cancer patients, and its loss, particularly in triple negative breast cancer, could be having detrimental effects. This work helps elucidate molecular mechanisms of breast cancer health disparity and identifies putative biomarkers and therapeutic targets such as resistin, and the aurora B and polo-like kinase signaling pathways for treating AA breast cancer patients.

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p53 Expression in Triple Negative Breast Carcinomas: Evidence of Age-Related and Racial Differences

Cited by 3 publications

References 27 publications

Heavy metals effect on breast cancer progression

Heavy metals effect on breast cancer progression

Apoptosis regulator Bcl-2 is an independent prognostic marker for worse overall survival in triple-negative breast cancer patients

Differentially Expressed Transcripts and Dysregulated Signaling Pathways and Networks in African American Breast Cancer

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