p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinoma.

Hirvikoski, Pasi; Kumpulainen, E.; Virtaniemi, Jukka; Johansson, Risto; Haapasalo, Hannu; Marin, S; Halonen, Pirjo; Helin, H; Raitiola, Hannu; Pukander, J.; Kellokumpu‐Lehtinen, Pirkko; Kosma, Veli‐Matti

doi:10.1200/jco.1997.15.9.3111

Cited by 66 publications

(63 citation statements)

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“…In laryngeal SCC, Jin et al 29 reported that p53 overexpression was an independent prognostic factor for poor disease-free survival. In contrast, Hirvikoski et al 30 showed a favorable clinical outcome in patients with p53 overexpression. There are several reports showing no association between p53 overexpression and prognosis in laryngeal carcinoma [26][27][28] and in oral cancer.…”

Section: Discussionmentioning

confidence: 86%

“…Some studies showed no correlation, 19,26 -28 whereas others showed a significant correlation between p53 expression and prognosis. 21,29,30 Conversely, a majority of studies showed an association of p53 mutation with poor prognosis, 20,31 but some studies showed that there is no association between p53 mutation and prognosis. 19 Overexpression of bcl-x has been reported to protect tumor cells from apoptosis, 32 whereas increased bax expression promotes apoptosis induced by cytotoxic drugs and radiation.…”

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confidence: 99%

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Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Bandoh

Hayashi

Kishibe

et al. 2002

Cancer

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Section: Discussionmentioning

confidence: 86%

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confidence: 99%

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Bandoh

Hayashi

Kishibe

et al. 2002

Cancer

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“…The fraction of positive tumour cells was primarily analysed in a continuous scale but, for statistical calculations, the percentage distribution of p21 and AP-2 was divided into two groups using median as a cut-off level: ² 10%, > 10%, ² 30%, > 30% respectively. Finally, the percentage distribution of p53 was scored as previously: ² 20%, > 20% (Hirvikoski et al, 1997).…”

Section: Immunohistochemistry and Detection Of P21 P53 And Ap-2mentioning

confidence: 99%

p21/WAF1 expression in human colorectal carcinoma: association with p53, transcription factor AP-2 and prognosis

et al. 1999

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p21/WAF1 expression was studied in a series of 162 colorectal carcinoma patients and its relation to p53- and activator protein (AP)-2 expressions and to stage as well as survival was assessed. p21 expression was moderate or intense in 33% of the tumours, and 53% of the tumours had moderate or strong p53 staining intensity. Eighty-nine percent of the tumours showed a weak cytoplasmic AP-2 signal. As expected, p21 and p53 stainings were inversely related to each other ( P < 0.001). There was a significant positive association between p21 and AP-2 expression levels ( P = 0.01). p21 intensity and percentage were higher in Dukes' A and B stages ( P < 0.001). The cancer-related survival and recurrence-free survival (RFS) rates were significantly lower among patients with a low signal for p21 ( P < 0.001) and low p21 percentage in tumour epithelium ( P < 0.001). High p53 staining intensity in tumour epithelium predicted poor survival ( P = 0.01) and RFS ( P = 0.003). In the multivariate analysis, p21 percentage distribution independently predicted cancer-related survival in all cases, and p21 expression intensity in T1–4/N0–3/M0 and T1–3/N0/M0 cases. p21 percentage distribution was an independent predictor of RFS in all and T1–3/ N0/M0 cases. AP-2 staining did not reach any prognostic significance. These results suggest that the immunohistochemical detection of cyclin-dependent kinase inhibitor p21 could be used to predict more precisely the outcome of colorectal cancer patients. © 1999 Cancer Research Campaign

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“…In recent years, investigations on the importance of certain genetic and immunological markers (p53, Ki67, BNIP3, TGM2, and IGF1R) have begun. [7][8][9][10][11][12] The aim of this study was to determine the prognostic factors which have an impact on the treatment, in addition to side effects and survival rates in patients with larynx cancer.…”

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confidence: 99%

Treatment results, side effects and prognostic factors affecting survival in patients with larynx cancer

Yücel¹

2013

J Med Updates

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ÖzetAmaç: Bu çal›flmada, klini¤imizde tedavi edilen larinks kanserli hastalar›n tedavi sonuçlar›, tedavilerin yan etkileri ve hastalar›n sa¤kal›-m›n› etkileyen prognostik faktörlerin belirlenmesi amaçlanm›flt›r.Yöntem: Çal›flmada 90 hasta verisi analiz edilmifltir. Hastalar›n performans statüsü 2010'da revize edilmifl Do¤u Onkoloji ‹flbirli¤i Grubu (Eastern Cooperative Oncology Group, ECOG) skorlama sistemine göre de¤erlendirilmifltir. Bulgular:Hastalar›n %97'si erkek ve %3'ü kad›n olup, medyan yafl› 59 (37-86) idi. Erken evre %43, lokal ileri evre %55, metastatik evre kanser %2 hastada saptand›. Hastalar›n %53'ünü glottik kanserler, %47'sini supraglottik kanserler oluflturmaktayd›. Supraglottik kanserlerin performans durumu (p=0.022), grade (p=0.033), T evresi (p=0.034), lenf nod metastaz› (p=0.001), hastal›k evresi (p=0.007) bak›m›ndan glottik kanserlere göre daha kötü özelliklere sahip oldu¤u saptand›. Medyan 15 (da¤›l›m: 5-96) ayda hastalar›n %17'sinde nüks, medyan 17 (da¤›l›m: 1-155) ayda da hastalar›n %12'sinde uzak metastaz tespit edildi. Hastalar›n sa¤kal›m›n› komorbidite (p=0.032), performans durumu (p=0.022), hemoglobin düzeyi (p=0.003), T evresi (p=0.006), hastal›k evresi (p=0.011), kilo kayb› (p=0.002) etkilemekteydi. Kemoradyoterapi uygulanan hastalarda mukozit (p<0.001), bulant› kusma (p<0.001), kilo kayb› (p=0.005), nötropeni (p=0.001) ve anemi (p=0.003), radyoterapi uygulanan hastalara göre daha fazla gözlenmifltir.Sonuç: Hemoglobin düzeyi, T evresi, komorbidite ve kilo kayb› bu hastalar için ba¤›ms›z prognostik faktörler olmufltur.Anahtar sözcükler: Larinks kanseri, sa¤kal›m, prognoz, yan etki. AbstractObjective: Our aim was to determine the treatment results, side effects and the prognostic factors affecting survival in patients with larynx cancer treated in our clinic. Methods:Data of a total of 90 patients with larynx carcinoma were included in the study. The patients' performance scores were evaluated according to the Eastern Cooperative Oncology Group (ECOG) system.Results: Eighty-seven (97%) patients were male and three patients (3%) were female. The median age of the patients was 59 (37-86) years. Early-stage, locally advanced stage, and metastatic disease were detected in 43, 55, and 2% of the patients, respectively. Laryngeal cancers were observed in the glottic (53%), and supraglottic (47%) regions. Performance score (p=0.022), grade (p=0.033), lymph node metastasis (p=0.001), T stage (p=0.034) and disease stage (p=0.007) were significantly unfavourable in supraglottic cancers compared to glottic cancers. Recurrence was observed in 17% of the patients in a median 15 (range: 5-96) months. Distant metastasis was observed in 12% of the patients in a median 17 (range: 1-155) months. The factors affecting survival were the presence of comorbidities (p=0.032), performance status (p=0.022), hemoglobin level (p=0.003), T stage (p=0.006), disease stage (p=0.011), and weight loss (p=0.002). When RT-and CRT-associated side effects were compared, the incidence of adverse effects such as mucositis ...

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p53 expression and cell proliferation as prognostic factors in laryngeal squamous cell carcinoma.

Cited by 66 publications

References 45 publications

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

Prognostic value of p53 mutations, bax, and spontaneous apoptosis in maxillary sinus squamous cell carcinoma

p21/WAF1 expression in human colorectal carcinoma: association with p53, transcription factor AP-2 and prognosis

Treatment results, side effects and prognostic factors affecting survival in patients with larynx cancer

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