P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice

Zhang, Kai; Liu, Jingyan; You, Xintong; Kong, Ping; Song, Yichen; Cao, Lu; Yang, Song; Wang, Wenbing; Fu, Qiang; Ma, Zhangqiang

doi:10.1016/j.neulet.2015.12.043

Cited by 86 publications

(51 citation statements)

References 35 publications

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“…41) Recently, P2X7 was reported as a novel target of depression treatment in mice. 42) We showed here that keamine down-regulated the P2X7 protein levels in hippocampus following CRS, indicated that P2X7 could be also involved in ketamine's antidepressant effects. Future studies to test whether using P2X7 inhibitors brilliant blue G could have the same result with the anti-depressive effects of ketatmine could further confirm the critical role of P2X7 in the action of ketamine.…”

Section: Discussionmentioning

confidence: 69%

Ketamine Alleviates Depressive-Like Behaviors <i>via</i> Down-Regulating Inflammatory Cytokines Induced by Chronic Restraint Stress in Mice

Tan

Wang

Chen

et al. 2017

Biological & Pharmaceutical Bulletin

123

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The purpose of the present study was to investigate whether ketamine's rapid antidepressant effects were associated with its anti-inflammatory actions and to explore the underlying molecular mechanism. Depressive-like behaviors was induced in mice using chronic restraint stress (CRS) method. Anti-depressive effects of ketamine were evaluated by forced swimming tests (FST) and sucrose preference test (SPT). Subsequently, brain tissue was harvested to investigate inflammatory response in the hippocampus via investigating reactive microglia numbers, serum cytokines levels and the toll-like receptor type 4 (TLR4)/p38 mitogen-activated protein kinase (MAPK) pathway. CRS exposure caused depressive-like behaviors in mice, which was associated with increased pre-inflammatory cytokines (interleukin (IL)-1β, tumor necrosis factor (TNF)-α and IL-6) levels, reactive microglia numbers and up-regulated regulatory molecules such as TLR4/p38 and P2X7 receptor in hippocampus. Such neurobehavioral and biochemical abnormalities were normalized by ketamine treatment. CRS-induced depression-like behaviours are associated with activation of hippocampal inflammatory response, whereas down-regulation of pro-inflammatory cytokines may contribute to ketamine's antidepressant effects in mice.

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Section: Discussionmentioning

confidence: 69%

Ketamine Alleviates Depressive-Like Behaviors <i>via</i> Down-Regulating Inflammatory Cytokines Induced by Chronic Restraint Stress in Mice

Tan

Wang

Chen

et al. 2017

Biological & Pharmaceutical Bulletin

123

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“…[16] Zhang et al found that chrysophanol could exert antidepressant effect by inhibiting the P2X7/NF-jB signalling pathway, which reduced the levels of IL-6, IL-1b, TNF-a, P2X7, phosphorylated nuclear factor-jB kinase a (p-IKKa), p-IKKb, p-IjBa and p-NF-jBp65 in rats with depression. [50] In the inflammatory response and oxidative stress in BV2 mouse glial cells induced by LPS, chrysophanol attenuated the release of iNOS, PGE2, TNF-a, IL-6 and IL-1b by inhibiting p38, ERK and JNK activation in activated microglia, and reduced ROS-mediated cell damage and inhibited DNA oxidation in BV2 cells. [51] In HMC-1 cells, chrysophanol inhibited the activation of caspase-1 and NF-jB.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

“…In vitro [16] Inhibition of P2X7/ NF-jB signalling pathway Male ICR mice 20 and 40 mg/kg In vivo [50] Reduce the number of eosinophils and the inflammatory cytokines…”

Section: Lmmentioning

confidence: 99%

Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Xie

Tang

Song

et al. 2019

Journal of Pharmacy and Pharmacology

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Objective Chrysophanol is a natural anthraquinone, also known as chrysophanic acid and 1,8‐dihydroxy‐3‐methyl‐anthraquinone. It has been widely used in the food and pharmaceutical fields. This review is intended to provide a comprehensive overview of the pharmacology, toxicity and pharmacokinetic researches of chrysophanol. Key finding Information on chrysophanol was collected from the Internet database PubMed, Elsevier, ResearchGate, Web of Science, Wiley Online Library and Europe PM using a combination of keywords including ‘pharmacology’, ‘toxicology’ and ‘pharmacokinetics’. The literature we collected included from January 2010 to June 2019. Chrysophanol has a wide spectrum of pharmacological effects, including anticancer, antioxidation, neuroprotection, antibacterial and antiviral, and regulating blood lipids. However, chrysophanol has obvious hepatotoxicity and nephrotoxicity, and pharmacokinetics indicate that the use of chrysophanol in combination with other drugs can reduce toxicity and enhance efficacy. Summary Chrysophanol can be used in many diseases. Future research directions include how the concentration of chrysophanol affects pharmacological effects and toxicity; the mechanism of synergy between chrysophanol and other drugs.

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“…Clinical and preclinical studies indicated that inflammatory cytokines increased in depressed patients and animals (20). The anti-inflammatory effect of Umb was partially evidenced by the detections of cytokines IL-6, IL-1b, and TNF-a.…”

Section: Effects Of Umb On Cytokines Productionmentioning

confidence: 99%

Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-κB pathway

Kong

Long

et al. 2016

IUBMB Life

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P2X7 as a new target for chrysophanol to treat lipopolysaccharide-induced depression in mice

Cited by 86 publications

References 35 publications

Ketamine Alleviates Depressive-Like Behaviors <i>via</i> Down-Regulating Inflammatory Cytokines Induced by Chronic Restraint Stress in Mice

Ketamine Alleviates Depressive-Like Behaviors <i>via</i> Down-Regulating Inflammatory Cytokines Induced by Chronic Restraint Stress in Mice

Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Retracted: Umbelliferone reverses depression-like behavior in chronic unpredictable mild stress-induced mice via RIP140/NF-κB pathway

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