Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Xie, Long; Tang, Hongwei; Song, Jung Soo; Long, Jiaying; Zhang, Lin-Lin; Li, Xiaofang

doi:10.1111/jphp.13143

Cited by 93 publications

(64 citation statements)

References 91 publications

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“…Berg, also called as 1, 8‐dihydroxy‐3‐methyl‐anthraquinone. [ 35,36 ] Chrysophanol is considered to have multiple biological activities, including neuroprotection, anticancer, antibacterial, antiviral and anti‐oxidation. [ 37 ] Chrysophanol could inhibit the excessive activation of astrocytes in the hippocampal CA3 region and reduce cognitive impairment and neuronal loss.…”

Section: Quinones and Its Role In Admentioning

confidence: 99%

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Chen

Gao

Peng

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Alzheimer's disease (AD) is a hidden neurological degenerative disease, which main clinical manifestations are cognitive dysfunction, memory impairment and mental disorders. Neuroinflammation is considered as a basic response of the central nervous system. NLRP3 (Nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3) inflammasome is closely related to the occurrence of neuroinflammation. Activation of the NLRP3 inflammasome results in the release of cytokines, pore formation and ultimately pyroptosis, which has demonstrated one of the critical roles in AD pathogenesis. Inhibition of the activity of NLRP3 is one of the focuses of the research. Therefore, NLRP3 represents an attractive pharmacological target, and discovery compounds with good NLRP3 inhibitory activity are particularly important. Key findings Quinones have good neuroprotective effects and prevent AD, which may be related to their regulation of inflammatory response. The molecular docking was used to explore 12 quinones with AD prevention and treatment and NLRP3. Docking results showed that the combination of anthraquinones and NLRP3 were the best, and the top two chemical compounds were Purpurin and Rhein, which are the most promising NLRP3 inhibitors. Summary These quinones may provide the theoretical basis for finding lead compounds for novel neuroprotective agents. Quinones as NLRP3 inflammasomes inhibitors Da-bao Chen et al.

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Section: Quinones and Its Role In Admentioning

confidence: 99%

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Chen

Gao

Peng

et al. 2020

Journal of Pharmacy and Pharmacology

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“…For example, emodin (M4) from Rheum palmatum L. has been reported to exhibit promising anti-inflammatory, anti-oxidative, hepatoprotective, and anticancer effects (Dong et al, 2016). Again as an example, chrysophanol (M5) from Rheum palmatum L. has been established to have anticancer, antioxidation, neuroprotection, antibacterial and antiviral properties (Xie et al, 2019). Therefore, by retrieving in DrugBank and NCBI database, we listed these compounds as typical pharmacodynamic candidates of SFH formula.…”

Section: Discussionmentioning

confidence: 99%

Systems Pharmacology and Verification of ShenFuHuang Formula in Zebrafish Model Reveal Multi-Scale Treatment Strategy for Septic Syndrome in COVID-19

et al. 2020

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The outbreak of coronavirus disease 2019 (COVID-19) has affected millions of people worldwide. Critically ill COVID-19 patients develop viral septic syndrome, including inflammatory damage, immune dysfunction, and coagulation disorder. In this study, we investigated ShenFuHuang formula (SFH), a traditional Chinese medicine, which has been widely used as complementary therapy for clinical treatment of COVID-19 in Wuhan, to understand its pharmacological properties. Results of systems pharmacology identified 49 active compounds of SFH and their 69 potential targets, including GSK3b, ESR1, PPARG, PTGS2, AKR1B10, and MAPK14. Network analysis illustrated that the targets of SFH may be involved in viral disease, bacterial infection/mycosis, and metabolic disease. Moreover, signaling pathway analysis showed that Toll-like receptors, MAPK, PPAR, VEGF, NOD-like receptor, and NF-kappa B signaling pathways are highly connected with the potential targets of SFH. We further employed multiple zebrafish models to confirm the pharmacological effects of SFH. Results showed that SFH treatment significantly inhibited the inflammatory damage by reducing the generation of neutrophils in Poly (I:C)-induced viral infection model. Moreover, SFH treatment could improve the phagocytosis of macrophages and enhance the expression of immune genes in an immune deficiency model. Furthermore, SFH treatment exhibited promising anti-thrombosis effect in a thrombus model. This study provided additional evidence of SFH formula for treating COVID-19 patients with septic syndrome using multiple-scale estimation.

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“…Apart from that emoidin can inhibit the 3a ion channel of SARS-COV and HCOV-0C43 and the virus release of HCOV-0C43 [27]. Chrysophanol can inhibit the formation of biofilm and has antibacterial effect [28].…”

Section: (B))mentioning

confidence: 99%

Trying to Explain the Theoretical Basis of Traditional Chinese Medicine “Huashi Baidu Fang” in the Treatment of Coronavirus Disease 2019 with Western Medical Theory: A Review

Song¹,

Chen²

2020

ABB

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Purpose: This work is aimed to explain the theoretical basis of "Huashi Baidu Fang" in the treatment of coronavirus disease 2019 (COVID-19) with western medical theory. Methods: We analyze the "Diagnosis and Treatment Protocol for COVID-19 (Version 1 to Version 7)" made by China, "Clinical management of severe acute respiratory infection when novel coronavirus (2019-nCoV) infection is suspected-Interim guidance" made by World Health Organization (WHO), "Therapeutic Guidelines: Respiratory (Version 5)", "Therapeutic Guidelines: Gastrointestinal (Version 5)" and "Therapeutic Guidelines: Antibiotic (Version 15)" published by Australia, and the origin of classical prescription of "Huashi Baidu Fang": "Shanghanlun (Treatise on Febrile Diseases)", "Jinkui Yaolue (Synopsis of Golden Chamber)" and "Wenyi Lun (The Epidemic Febrile Disease)". We search the dictionary of traditional Chinese medicine (Version II) manually. And we search literatures from 2001 to 2020 on Wiley online library. We conduct a comparative study among the symptoms of TCM formulations in "Huashi Baidu Fang", the pathogenesis and clinical manifestation of COVID-19 and COPD with acute gastrointestinal inflammation. And we carry out pharmacological inquiry of "Huashi Baidu Fang". Results: The clinical manifestations of respiratory symptoms and gastrointestinal tract of syndrome of lung obstruction due to epidemic toxin and acute exacerbation of COPD are almost the same; The formulations used in "Huashi Baidu Fang" are consistent with the pharmacological activity of the drug recommended in the Therapeutic Guidelines. Conclusion: "Huashi Baidu Fang" may play a positive role in COVID-19.

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Chrysophanol: a review of its pharmacology, toxicity and pharmacokinetics

Cited by 93 publications

References 91 publications

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Quinones as preventive agents in Alzheimer’s diseases: focus on NLRP3 inflammasomes

Systems Pharmacology and Verification of ShenFuHuang Formula in Zebrafish Model Reveal Multi-Scale Treatment Strategy for Septic Syndrome in COVID-19

Trying to Explain the Theoretical Basis of Traditional Chinese Medicine “Huashi Baidu Fang” in the Treatment of Coronavirus Disease 2019 with Western Medical Theory: A Review

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