P208 Impact of Morning Symptoms Experienced by COPD Patients on Exacerbation Risk, Rescue Inhaler Usage and Normal Daily Activities

Abstract

Poster sessionsThere was a significant association between inhaler satisfaction and compliance (χ 2 − df=89.7; p<0.001). Other factors related to greater compliance, though to a lesser degree, were fewer maintenance drugs (χ 2 − df=17.7; p<0.001) and male gender (χ 2 − df=2.9; p<0.05). Severity of breathlessness, age and ethnicity were not significantly associated with compliance (p>0.05). Higher compliance scores were significantly associated with better health outcomes (Table). There was also a direct association between inhaler satisfaction and better health outcomes (exacerbations and EQ-5D, p<0.001).Conclusions Inhaler satisfaction appears to be significantly associated with COPD treatment compliance, and patients with greater compliance experience better health outcomes, including less frequent exacerbations.

A ferret model of COPD-related chronic bronchitis

“…In COPD patients, cough frequency is highest in the morning, especially in those patients with severe disease (37,38). In addition, early-morning cough can also be used to predict exacerbation risk, rescue inhaler usage and response, ability to carryout normal daily activities, and overall health-related quality of life (39)(40)(41). Thus, smoke-exposed ferrets serve as an effective laboratory tool to evaluate pathogenic events leading up to chronic cough, elucidate mechanisms, and test emerging interventions.…”

The impact of morning symptoms on daily activities in chronic obstructive pulmonary disease

“…Although symptoms can be experienced throughout the day, there is a growing body of evidence that those occurring in the morning may be more severe with the consequent impact on patients' ability to perform tasks 1,5,6 . Moreover, one of these papers suggested that symptoms occurring in the morning may be associated with an increased frequency of exacerbations 6 .…”

Perspectives of pharmacological therapy of chronic obstructive pulmonary disease: opportunities of dual bronchodilation and a role of inhaled steroids. Expert Council Consensus

“…отмечавших по утрам такие симптомы, как кашель и чрезмерное отделение мокроты, по сравнению с пациентами без утренних симптомов отмечалась более высокая частота обострений за последние 12 мес., а также более частое использование препа ратов, облегчающих симптомы в течение дня [5].…”

“…Установлена прямая зависимость между числом обострений ХОБЛ и утренними симп томами [5]. В исследовании показано, что у больных,…”