p16 expression in relation to human papillomavirus in anogenital lesions

Samama, Brigitte; Lipsker, Dan; Boehm, Nelly

doi:10.1016/j.humpath.2006.01.001

Cited by 28 publications

(27 citation statements)

References 33 publications

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“…The percentages of lesions showing immunoreactivity for p16 increased from AIN1 to invasive cancers, the latter being all positive (Fig. 2J, K), confirming previous data [17,18]. In HIV-positive patients, the percentage of AIN2 expressing p16 was twice that in HIV-negative patients (Table 3).…”

Section: Expression Of P16 and Ki67 In Anal Lesionssupporting

confidence: 88%

“…One corresponded to a mix of total genomes containing the conserved HPV region, others were specific for each type of HPV as follows: 6, 11, 16, 18, 31, or 33 [2]. If results for the latest were negative, we tested a high-risk HPV probe corresponding to a mix of 16,18,31,33,35,39,45, 51, 52, 56, 58, 59, and 68 types (Dakopatt). The signal was amplified with the biotinyl-tyramide complex, using diaminobenzidine as the chromogen (Genpoint kit, Dakopatt).…”

Section: In Situ Molecular Techniques For Hpv Detectionmentioning

confidence: 99%

“…VEGFR1 is a particularly promising candidate because (i) it binds 3 ligands (VEGFA, VEGFB, and placenta growth factor), (ii) it is up-regulated by hypoxia, which frequently occurs in carcinoma [15], and (iii) it is a potential target for anticancer vaccines against angiogenesis [16]. Studies have noted that the overexpression of p16 and/or Ki67 is correlated with high-risk HPV infection, high-grade anal lesions, and invasive cancers [17,18].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus

et al. 2009

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Section: Expression Of P16 and Ki67 In Anal Lesionssupporting

confidence: 88%

Section: In Situ Molecular Techniques For Hpv Detectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus

et al. 2009

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“…5), as compared to the keratinizing type carcinomas of the same site [6,7,22]. This immunohistochemical profile is analogous to that seen in HPV positive anogenital carcinomas [23][24][25]. As mentioned above the majority of oropharyngeal HPVrelated lesions start at the bottom of the crypts of the palatine and lingual tonsils, and thus are inaccessible to routine cytologic smears.…”

Section: Immunohistochemistrymentioning

confidence: 58%

Human Papillomavirus (HPV) Related Carcinomas of the Upper Aerodigestive Tract

El‐Mofty

2007

Head and Neck Pathol

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Epidemiologic, clinical, morphologic and molecular evidence show that high risk HPV, particularly type 16, is a prerequisite for some carcinomas of the upper aerodigestive tract (UADT), particularly tonsil and base of tongue. Sexual transmission is an important mode of infection while tobacco use and excessive drinking are not considered risk factors. HPV + tumors are distinct clinically and pathologically. They are more common in young patients (\40 years) with a male to female ratio of 4:1. They usually present as a small or occult primary tumor with advanced neck disease. Microscopically they are nonkeratinizing squamous cell carcinomas with basaloid features, excessive mitosis and comedo type necrosis. The tumors have a distinct immunohistochemical profile characterized by strong and diffuse p16 reactivity, low or negative p53 staining and high Ki67 labeling scores. HPV + carcinomas are more radio-sensitive and have a better prognosis than the classical keratinizing SCC of the UADT. An anti-HPV vaccine has recently been made available for prevention of cervical cancer. The impact of the vaccine on the prevalence of HPV related carcinomas of the UADT is currently not known but likely beneficial.Keywords Human papillomavirus Á HPV16 Á Upper aerodigestive tract Á Oropharynx Á Tonsils Á Base of tongue Á Non-keratinizing squamous cell carcinoma Á p16 Á Sexual transmission Á Radiosensitivity Á Vaccine Background

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“…In HPV-associated tumours, the expression of tumour suppressor protein p16 INK4a is increased due to inactivation of retinoblastoma protein by high-risk HPV oncoprotein E7, unlike other cancers in which p16 INK4a gets inactivated 13 14. Overexpression of p16 INK4a is therefore considered a reliable marker for HPV-induced cervical intraepithelial neoplasia and head and neck SCC 15…”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus: a predictor of better survival in ocular surface squamous neoplasia patients

et al. 2012

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Background Although human papillomavirus (HPV) has been implicated in the pathogenesis of ocular surface squamous neoplasia (OSSN), no study has so far dealt with the prognostic role of HPV. In this study the presence and significance of HPV in OSSN and its correlation with p16INK4a immunoexpression was determined. Methods HPV was detected by HPV-L1 capsid genespecific multiplex PCR using PGMY09/11 primers, and genotyping was done by linear array on 64 OSSN patients and 15 conjunctival controls. p16INK4a immunoexpression as a marker for HPV presence was also evaluated. Results The HPV genome was detected in 11% of cases by multiplex PCR, and all positives belonged to a high-risk HPV16 genotype. p16INK4a Overexpression was seen in 28% (18/64) of cases. Control conjunctival tissues were negative for HPV and p16INK4a expression. The presence of HPV was associated with significantly improved disease-free survival ( p=0.02) as well as p16INK4a overexpression ( p=0.001). The sensitivity and specificity of p16INK4a as a marker for HPV presence was 86% and 79%, respectively, with a positive predictive value of 33% and a negative predictive value of 98%. Conclusions The results of this study point towards HPV as a predictor of better survival in a subset of HPV-positive OSSN patients. Although p16 INK4a immunoexpression is a useful indicator of HPV presence in OSSN, confirmation by multiplex PCR is necessary.

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p16 expression in relation to human papillomavirus in anogenital lesions

Cited by 28 publications

References 33 publications

Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus

Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus

Human Papillomavirus (HPV) Related Carcinomas of the Upper Aerodigestive Tract

Human papillomavirus: a predictor of better survival in ocular surface squamous neoplasia patients

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