Human Papillomavirus (HPV) Related Carcinomas of the Upper Aerodigestive Tract

El‐Mofty, Samir K.

doi:10.1007/s12105-007-0021-6

Cited by 24 publications

(19 citation statements)

References 34 publications

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“…From reported series, HPV DNA has been identified in the airway papillomas, the most common types are low risk HPV 6 and HPV 11, the same types responsible for the majority of genital condylomata or warts. In addition, HPV infection of the oral cavity and pharyngeal area has been thought to be sexually transmitted as well [8,12,23]. However, the mode of HPV transmission in the external ear canal is still unknown.…”

Section: Discussionmentioning

confidence: 99%

“…Others, called ''low-risk'' types, may cause mild cytologic abnormalities and genital warts, as well as laryngeal papillomatosis and oral condyloma accuminata. The most common high-risk subtypes are types 16 and 18, while the most common of the lowrisk subtypes are types 6 and 11 [12]. Techniques for detection of HPV in squamous papillomas include immunohistochemistry, Southern blot hybridization, ISH, or PCR.…”

Section: Introductionmentioning

confidence: 99%

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Papillomas of the External Ear Canal: Report of Ten cases in Chinese Patients with HPV In Situ Hybridization

Wang

Yee

Wen

et al. 2009

Head and Neck Pathol

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Squamous papilloma is a benign exophytic proliferation which can occur occasionally in the external ear canal. It is widely assumed that the Human Papilloma Virus (HPV) is an etiologic factor of papillomas. Available techniques for detection of HPV genomes include immunohistochemistry, Southern blot hybridization, in situ hybridization (ISH), and polymerase chain reaction. To our knowledge, HPV typing has not been reported on tissue sections of papillomas in the external ear canal. We report HPV ISH analysis in ten cases of papillomas, involving the external ear canal in Chinese patients. These papilloma excrescences were less than 1 cm in diameter, and were benign morphologically. Automated HPV ISH analysis was performed for the hybridization of DNA probes, including both low-risk and high-risk HPV subtypes. HPV ISH results revealed that seven out of ten cases were positive for low-risk HPV (6, 11), three cases demonstrated no hybridization for low-risk HPV probe, and none of the cases revealed any detection of high-risk HPV (16, 18, 31, 33, 35, 39, 51, 52, 56, 58, and 66). On follow-up after 18-29 months (average 24.5 months), eight patients were doing well, with no local recurrence after excision. Two patients were lost to follow-up. Our results confirm that benign papillomas of the external ear canal are associated with low-risk HPV infection with benign behavior and neither recurrence nor high grade dysplasia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Papillomas of the External Ear Canal: Report of Ten cases in Chinese Patients with HPV In Situ Hybridization

Wang

Yee

Wen

et al. 2009

Head and Neck Pathol

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“…2,3 This may, in part, be explained by the increased prevalence of a subset of oropharyngeal carcinoma associated with human papillomavirus (HPV), mostly HPV-16. [4][5][6][7] Importantly, p16 overexpression is noted in almost all HPV-associated head and neck cancers and indicates that the virus is transcriptionally active. Patients with HPV-positive, p16-positive oropharyngeal carcinomas are slightly younger than those with tumors not associated with HPV and show improved survival.…”

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confidence: 99%

Human papillomavirus-associated oral intraepithelial neoplasia

2013

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This study evaluated an unusual subset of oral epithelial dysplasia for the presence of transcriptionally active high-risk HPV subtypes and to further characterize the histological criteria for this condition. There were 20 cases diagnosed as epithelial dysplasia with marked apoptosis of the anterior oral cavity. Clinical and followup data were collected and histopathological features were documented. Immunoperoxidase studies were performed for p16 and in situ hybridization studies were performed for low-and high-risk HPV sub-types. Gender-and site-matched controls of conventional moderate-to-severe oral epithelial dysplasia were similarly evaluated using immunoperoxidase studies for p16 and in situ hybridization; the number of apoptotic cells for study and control cases was counted at two different tissue sites. There were 17 men and 3 women with a median age of 56 years. Seventeen lesions were described as white and five were described as rough or papillary. Thirteen were located on the lateral or ventral tongue, some extending onto the floor of the mouth. Epithelial hyperplasia with marked karyorrhexis and apoptosis were present in all the cases, along with features of conventional oral epithelial dysplasia. A statistically significant number of apoptotic cells were identified in the study cases when compared with controls (P40.0001). Twenty cases were positive for high-risk HPV by in situ hybridization and all 19 nineteen cases evaluated for p16 demonstrated overexpression. Two patients were diagnosed with squamous cell carcinomas and one patient developed recurrent disease. We report a subset of oral epithelial dysplasia that occurs mostly in adult men on the ventral or lateral tongue and is positive for high-risk HPV and for p16. We propose use of the term 'HPV-associated Oral Intraepithelial Neoplasia' to characterize these lesions of the oral cavity for consistency in nomenclature with HPV-associated lesions of the lower anogenital tract. One case recurred and one developed invasive cancer. Keywords: HPV apoptotic oral epithelial dysplasia; koilocytic dysplasiaIn the United States, smoking frequency has decreased by 16% and the overall number of cases of cancer of the oral cavity and pharynx has fallen by 18% since 1975. 1 However, rates of cancers of the oral tongue, base of tongue, and palatine tonsils have continued to rise by 2-4% among younger men. 2,3 This may, in part, be explained by the increased prevalence of a subset of oropharyngeal carcinoma associated with human papillomavirus (HPV), mostly HPV-16. 4-7 Importantly, p16 overexpression is noted in almost all HPV-associated head and neck cancers and indicates that the virus is transcriptionally active. Patients with HPV-positive, p16-positive oropharyngeal carcinomas are slightly younger than those with tumors not associated with HPV and show improved survival. 8,9 It is generally believed that HPV has only a minor role in squamous cell carcinoma of the anterior oral cavity, because it has been identified in only 2.9-5.9% of cases and the beha...

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“…(1,2) Human papillomavirus is divided into low-risk and high-risk types, depending on the carcinogenic power. (3) It has been conclusively established that more than 99% of uterine cervical cancers are associated with HPV infection. (2,4) Because HPV-associated cancers may be prevented with vaccination, (5)(6)(7) it is important to determine whether cancer of extracervical organs is associated with HPV infection.…”

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confidence: 99%

Prevalence of human papillomavirus in mobile tongue cancer with particular reference to young patients

et al. 2011

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The carcinogenetic role of human papillomavirus (HPV) in mobile tongue cancer remains unclear because of conflicting results reported in the literature. This disparity is likely to be due to variations in the samples and methods used. Furthermore, despite a tendency for increased prevalence of mobile tongue cancer in young adults, only a few reports specifically in young patients have been published. In the present study on 32 patients, including six in their 20s, we genotyped the prevalence of HPV using a highly sensitive detection tool in fresh-frozen samples from surgical specimens and a novel detection device with electrochemical DNA chip and loop-mediated isothermal amplification. In addition, we confirmed HPV prevalence by in situ hybridization and immunohistochemistry for the p16INK4a protein, regarded as a biomarker of HPV-associated cancers. The frequency of 13 genotypes of highrisk HPV was 0 ⁄ 32 (0%), which was further confirmed by in situ hybridization. Overexpression of p16INK4a protein was observed in six of the 32 patients (19%), with four (67%) also overexpressing p53. Because there is usually a lack of p53 overexpression in HPVassociated cancer, it is unlikely that p16INK4a protein overexpression is correlated with HPV infection. Consequently, it is unlikely that HPV infection plays an important role in mobile tongue carcinogenesis, in particular in young adults. In addition, our data suggest that the overexpression of p16INK4a protein is not an appropriate biomarker for HPV association in mobile tongue carcinogenesis. (Cancer Sci 2012; 103: 161-168) H uman papillomavirus (HPV) is a small DNA virus and more than 130 different types of HPV have been identified based on DNA sequence variations.(1,2) Human papillomavirus is divided into low-risk and high-risk types, depending on the carcinogenic power.(3) It has been conclusively established that more than 99% of uterine cervical cancers are associated with HPV infection.(2,4) Because HPV-associated cancers may be prevented with vaccination, (5)(6)(7) it is important to determine whether cancer of extracervical organs is associated with HPV infection. (8,9) Among the head and neck cancers, oropharyngeal cancer, particularly tonsillar cancer, and basal tongue cancer are known to be strongly associated with HPV infection.(3) However, the role of HPV in mobile tongue cancer (MTC) remains unclear because of the disparity of results published so far, which have reported HPV infection rates ranging from 0% to 100%. (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) This disparity may be due to differences in the types of samples used and the methods of detection. A recent study has reported an increasing incidence of MTC among young adults.(21) Thus far, alcohol consumption and heavy cigarette smoking have been suggested as causal factors for MTC. (11,13) However, it is difficult to explain the high incidence of MTC in young adults simply as a result of accumulated exposure to alcohol and smoking. (11,21,22) To date, there have been only a few reports on re...

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Human Papillomavirus (HPV) Related Carcinomas of the Upper Aerodigestive Tract

Cited by 24 publications

References 34 publications

Papillomas of the External Ear Canal: Report of Ten cases in Chinese Patients with HPV In Situ Hybridization

Papillomas of the External Ear Canal: Report of Ten cases in Chinese Patients with HPV In Situ Hybridization

Human papillomavirus-associated oral intraepithelial neoplasia

Prevalence of human papillomavirus in mobile tongue cancer with particular reference to young patients

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