Papillomas of the External Ear Canal: Report of Ten cases in Chinese Patients with HPV In Situ Hybridization

Wang, Shuyi; Yee, Herman; Wen, Hannah Y.; Wang, Beverly Y.

doi:10.1007/s12105-009-0131-4

Cited by 14 publications

(28 citation statements)

References 34 publications

(43 reference statements)

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“…Verruca vulgaris is caused by an HPV infection, and there are over 100 human papilloma DNA viruses that belong to the DNA papovaviridae family [ 1 2 3 4 5 ]. The most common sites of infection are the hands, feet and face [ 1 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most common sites of infection are the hands, feet and face [ 1 ]. Histopathological examination is used for a definitive diagnosis, and revealed characteristic features of hyperkeratosis, papillomatosis, parakeratosis, acanthosis, and koilocytosis [ 3 4 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…Verruca in the EAC has rarely been reported. It is associated with low-risk HPV infections (types 6 and 11) that often result in a benign clinical course with no recurrence or malignant transformation [ 3 4 5 ]. The mode of HPV transmission to EAC is currently not known.…”

Section: Discussionmentioning

confidence: 99%

“…EAC infections are thought to be associated with a history of repeated manipulation using the finger tips or ear picking tools. In addition, it has been suggested that the hair follicles may serve as possible reservoirs [ 2 3 4 5 ]. EAC verruca causes mechanical obstruction which can lead to pressure necrosis of the adjacent bone or conductive hearing impairments, although tympanic membrane involvement is seldom reported [ 2 4 ].…”

Section: Discussionmentioning

confidence: 99%

“…The most common sites of infection are the hands, feet and face [ 1 ]. Verruca in the external auditory canal (EAC) has rarely been reported [ 2 3 4 5 ]. A previous case report introduced surgical excision for verruca treatment because there was no available nonsurgical treatment for verruca in the EAC [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

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Treatment of Verruca Vulgaris in Both External Auditory Canals Using Bleomycin Injections

Lee

Burm

Yang

et al. 2015

Clin Exp Otorhinolaryngol

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Verruca vulgaris is caused by human papillomavirus (HPV) infections. Verruca in the external auditory canal (EAC) has rarely been reported. A previous case report introduced surgical excision as a treatment for verruca in the EAC. We present a case of verruca vulgaris in both EACs that was successfully treated with an intralesional bleomycin injection. A 32-year-old male patient presented with ear fullness and palpable lumps in both EACs. Both of his canals were filled with multiple pinkish, papillomatous masses. Verruca vulgaris was confirmed by skin biopsy. An otolaryngologist referred this patient and recommended surgical excision. However, we performed intralesional bleomycin injections for treatment. Twice intralesional bleomycin injections at one-month intervals had excellent results without recurrence, ulceration or scar formation. This result indicates that bleomycin injections may prove to be an effective first-line treatment of verruca in the EAC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Treatment of Verruca Vulgaris in Both External Auditory Canals Using Bleomycin Injections

Lee

Burm

Yang

et al. 2015

Clin Exp Otorhinolaryngol

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Clinical Characteristics of Patients With Papilloma in the External Auditory Canal

Luo

Peng

et al. 2020

The Laryngoscope

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Objectives To determine the clinical characteristics of papilloma involving the external auditory canal (PEAC) in a region of China. Study design A retrospective study. Methods Demographics, manifestations, imaging results, histopathology, and treatment of 67 patients diagnosed with PEAC in a period of 6 years were analyzed at Shanghai Eye, Ear, Nose and Throat Hospital in China. Results PEAC were encountered in patients between the ages of 12 and 82 years (mean 53.8 years). It was more prevalent in men (82%) than in women (18%) (P < .05). The clinical presentation was usually a mass in EAC, aural fullness, and hearing loss. Otoscopic and radiological examination were used together for initial diagnosis and pretreatment planning. Unilateral involvement was more common than bilateral involvement (P < .05). The average time between onset of first symptom and surgical resection and/or biopsy was 6.5 months (range, 0.25–60 months). All patients underwent gross total resection. In 5 patients, (7.5%) carcinoma was detected in the specimen. Fifteen patients (22%) had recurrence; recurrent tumors were detected after an average period of 10 months after surgery (range, 4–24 months). Conclusion PEAC is largely a benign lesion with a low risk of malignancy. Optimal management is via gross total resection. However, the risk of recurrence is high, which motivates a need for long‐term monitoring. Level of Evidence 4 Laryngoscope, 131:1132–1137, 2021

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Atypische kutane Infektionen mit genitalen HPV

Grussendorf-Conen¹

2010

Hautarzt

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Not only does genital "high risk HPV 16" play a significant role in cervical carcinomas, it is also the most commonly found mucosal virus in groups of well-defined but atypical infections on the skin. In this group are included 1. Bowen disease, 2. squamous cell carcinomas on fingertips and nail units, 3. squamous cell carcinomas of eyelids and conjunctiva, 4. papillomas and squamous cell carcinoma of the external auditory canal. Bowen disease is a carcinoma in situ with a good prognosis and usually does not turn into a Bowen carcinoma. There is a close relation to genital high risk HPV, but integration of HPV 16 DNA into the cellular genome is rarely found in Bowen disease, and seems to appear only when there is a development into Bowen carcinoma. It is unclear how mucosal HPV infect the skin. Most authors assume that genito-digital inoculation occurs. However, in many cases of cutaneous Bowen disease there is no evidence of genital change and in most reported cases there is no immunosuppression. Similarly, in the case of rare carcinomas of fingers and nail units HPV 16 and HPV 16 - related types seem implicated. There is an almost universal assumption that infection here occurs via genital-digital contact. Immunosuppression, for example due to organ transplant or HIV infection, accelerates the emergence and spread of carcinomas. The mechanism of these types of carcinogenesis appears to be similar to that of the formation of cervical carcinomas. Although the central role in triggering carcinogenesis is played by persistent HPV infection, as is the case in cervical carcinoma, further factors must play a part, for example the condition of the immune system. Loss of immunological control can lead to a lasting proliferation of HPV infected cells. Additional factors such as UV light and toxic substances may enhance carcinogenesis, by lowering local tissue immunity and thus reducing intra-cellular control.

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Papillomas of the External Ear Canal: Report of Ten cases in Chinese Patients with HPV In Situ Hybridization

Cited by 14 publications

References 34 publications

Treatment of Verruca Vulgaris in Both External Auditory Canals Using Bleomycin Injections

Treatment of Verruca Vulgaris in Both External Auditory Canals Using Bleomycin Injections

Clinical Characteristics of Patients With Papilloma in the External Auditory Canal

Atypische kutane Infektionen mit genitalen HPV

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