Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus

Walker, Francine; Abramowitz, Laurent; Benabderrahmane, Dalila; Duval, Xavier; Descatoire, Véronique; Hénin, Dominique; Lehy, Thérèse; Aparicio, Thomas

doi:10.1016/j.humpath.2009.05.010

Cited by 123 publications

(76 citation statements)

References 32 publications

(45 reference statements)

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“…He observed increased EGFR expression in 21 patients in total, which presents 55% [21]. Several other studies were then published, finding EGFR expression between 58% -100% [22][23][24][25]. In our study we observed EGFR expression in one half of the patients.…”

Section: Discussionsupporting

confidence: 67%

The prognostic significance of epidermal growth factor receptor expression in patients with anal carcinoma

Richter¹,

Jirásek²,

Dvořák³

et al. 2016

neo

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The aim of the present retrospective study was to evaluate the prognostic significance of epidermal growth factor receptor (EGFR) expression in patients treated with radiotherapy or concomitant chemoradiotherapy for squamous cell anal cancer (SCAC)Patients and methods: A total of 17 patients with SCAC (clinical stages I-III) were studies. All patients were treated with radiotherapy (total dose range 40 -68 Gy), 13 patients received concomitant chemotherapy (7 patients mitomycin/5-fluorouracil, 5 patients cisplatine/5-fluorouracil, 1 patient cisplatine weekly). EGFR expression in the pretreatment biopsieswas assessed with imunohistochemistry.Patients with EGFR expression had significantly shorter progression free survival (PFS) (p=0.0109; HR 9.38, 95% CI 1.75 -50.35) and overall survival (OS) (p=0.0351; HR 7.11, 95% CI 1.4 -36.13) than patients without expression EGFR. The 4-year PFS in patients with increased EGFR expression was only 28.57% (95% CI 17.07 -62.04%) compared to 87.5% (95% CI 64.58 -100%) in patients without EGFR expression. The 4-year OS in patients with increased EGFR expression was only 50.0% (95% CI 15.35 -84.65%) compared to 87.5% (95% CI 64.58 -100.0%) in patients without EGFR expression.Patients with expression EGFR had significantly shorter PFS and OS compared with patients without EGFR expression.

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Section: Discussionsupporting

confidence: 67%

The prognostic significance of epidermal growth factor receptor expression in patients with anal carcinoma

Richter¹,

Jirásek²,

Dvořák³

et al. 2016

neo

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“…The upregulation of fibroblast growth factor 17 (FGF17) and epidermal growth factor receptor (EGFR) by genistein clearly indicated the stimulation of different signaling pathways which have been known to be involved in cancer. FGF17 either enhances cellular proliferation or inhibits apoptosis [51] and EGFR induces signaling pathway in different kinds of cancer, namely, lung and anal cancer [52]. We found the downregulation of apoptosis-inducing factor (AIF) which pointed towards apoptosis induction.…”

Section: Discussionmentioning

confidence: 99%

Genistein Induces Deleterious Effects during Its Acute Exposure in Swiss Mice

Singh

Sharma

Rath

2014

BioMed Research International

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Genistein is a soy derived isoflavone. It has wide variety of therapeutic effects against certain diseases including cancer. Although toxic effects of genistein have been studied, its effect on the gene expression and the reason behind toxicity have not been identified yet. In the present study, genistein was administered to age and body weight matched Swiss mice at the doses of 125, 250, 500 and 1000 mg/kg. The biomarkers of hepatotoxicity in serum, liver histology, oxidative stress parameters in tissue homogenates, and global gene expression were examined. Elevated alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels and degenerated liver tissue were observed in 500, and 1000 mg/kg genistein treated groups. Oxidative stress was significant at these doses as considerable increase in lipid peroxidation (LPO) and decrease in total glutathione (GSH) were observed. Gene expression analysis showed 40 differentially expressed genes at twofold change and P < 0.05. Differentially expressed genes were corresponding to different biologically relevant pathways including metabolic and oxidative stress pathways. In 500 mg/kg group, Cyp4a14, Sult1e1, Gadd45g, Cidec, Mycs, and so forth genes were upregulated. These results suggested that the higher dose of genistein can produce several undesirable effects by affecting multiple cellular pathways.

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“…Thus, phosphorylated EGFR plays important roles in tumor invasion and metastasis (Arora and Simpson, 2008;Gong et al, 2008). Overactivation of EGFR including constant activation and mutations is often associated with cancer development and progression (Lynch et al, 2004;Walker et al, 2009). Our results showing that EGFR was strongly activated upon miR-24 overexpression appeared to be a consequence of miR-24 repressing PTPN9 and PTPRF expression.…”

Section: Mir-24 In Invasion and Metastasis 1449mentioning

confidence: 99%

MicroRNA miR-24 Enhances Tumor Invasion and Metastasis by Targeting PTPN9 and PTPRF to Promote EGF Signaling

Fang

et al. 2013

Journal of Cell Science

126

111

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SummaryMicroRNAs are known to play regulatory roles in gene expression associated with cancer development. We analyzed levels of the microRNA miR-24 in patients with breast carcinoma and found that miR-24 was higher in breast carcinoma samples than in benign breast tissues. We generated constructs expressing miR-24 and studied its functions using both in vitro and in vivo techniques. We found that the ectopic expression of miR-24 promoted breast cancer cell invasion and migration. In vivo experiments in mice indicated that the expression of miR-24 enhanced tumor growth, invasion into local tissues, metastasis to lung tissues and decreased overall mouse survival. In the miR-24-expressing cells and tumors, EGFR was highly phosphorylated, whereas expression of the phosphatases tyrosine-protein phosphatase non-receptor type 9 (PTPN9) and receptor-type tyrosine-protein phosphatase F (PTPRF) were repressed. We confirmed that miR-24 could directly target both PTPN9 and PTPRF. Consistent with this, we found that the levels of phosphorylated epidermal growth factor receptor (pEGFR) were higher whereas the levels of PTPN9 and PTPRF were lower in the patients with metastatic breast carcinoma. Ectopic expression of PTPN9 and PTPRF decreased pEGFR levels, cell invasion, migration and tumor metastasis. Furthermore, we found that MMP2, MMP11, pErk, and ADAM15 were upregulated, whereas TIMP2 was downregulated; all of which supported the roles of miR-24 in tumor invasion and metastasis. Our results suggest that miR-24 plays a key role in breast cancer invasion and metastasis. miR-24 could potentially be a target for cancer intervention.

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Growth factor receptor expression in anal squamous lesions: modifications associated with oncogenic human papillomavirus and human immunodeficiency virus

Cited by 123 publications

References 32 publications

The prognostic significance of epidermal growth factor receptor expression in patients with anal carcinoma

The prognostic significance of epidermal growth factor receptor expression in patients with anal carcinoma

Genistein Induces Deleterious Effects during Its Acute Exposure in Swiss Mice

MicroRNA miR-24 Enhances Tumor Invasion and Metastasis by Targeting PTPN9 and PTPRF to Promote EGF Signaling

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