p‐Coumaric acid prevents obesity via activating thermogenesis in brown adipose tissue mediated by mTORC1‐RPS6

Abstract

Brown adipose tissue (BAT) has long been recognized as an energy‐consuming organ and a possible target for combating metabolism disorder. Although numerous studies have demonstrated the ability of phytochemical phenolic acids to improve obesity by activating BAT, the underlying mechanism or mechanism therein remain obscure. In this study, diet‐induced obese mice, genetically obese mice, and C3H10T1/2 cells were used to examine the effects of p‐Coumaric acid (CA) on metabolism profiles. The results showed that CA prevented metabolic syndromes in the two mice models through the activation of BAT. This phenomenon was closely linked to the upregulation of uncoupling protein 1 (UCP1) and the accelerated burning of fatty acids and glucose, which consequently enhanced the energy expenditure and thermogenesis. Similar results were also obtained in vitro. Importantly, these effects were mediated by the mammalian target of rapamycin complex 1 (mTORC1)‐RPS6 pathway. These findings reveal, to the best of our knowledge for the first time, the close correlation between mTORC1‐RPS6 and BAT‐mediated thermogenesis, and, in addition, the key role played by mTORC1‐RPS6 in mediating phenolic acids‐induced activation of BAT, thus preventing obesity.

Peanut sprout rich in p-coumaric acid ameliorates obesity and lipopolysaccharide-induced inflammation and the inhibition of browning in adipocytes via mitochondrial activation

“…Recent evidence showed that PCA prevented obesity via upregulation of BAT function in dietinduced obese mice and leptin receptor-deficient (db/db) mice. 39 Our study also found that PCA treatment for only 7 days increased heat release and body temperature when mice were exposed to cold temperatures (8 °C). Although an iBATmarker, UCP1, was not altered with PCA; we assumed that the PCA concentration and duration were not sufficient to increase protein levels.…”

Amaranthus spinosus Attenuated Obesity-Induced Metabolic Disorders in High-Carbohydrate-High-Fat Diet-Fed Obese Rats

“…A variety of polyphenols, mainly phenolic acids, flavonoids, and their derivatives, have been identified and isolated from A. spinosus, and they include gallic acid, caffeic acid, vanillic acid, catechin, epicatechin, luteolin, ferulic acid, coumaric acid, cinnamic acid, derivatives of cinnamic acid, benzoic acid, derivatives of benzoic acid, rutin, derivatives of quinic acid, quercetin, derivatives of quercetin, kaempferol diglucoside, spinoside, amaranthoside, amaricin, and hesperidin (Supplementary Table 1). Many of these polyphenols are reported to have a ameliorating effect on obesity and different components of obesity-induced metabolic disorders including glucose intolerance, dyslipidemia, and hypertension, and impart protection against organ damage (79)(80)(81)(82)(83)(84)(85)(86). Thus, results obtained from this study narrating the ability of A. spinosus in inhibiting obesity and associated metabolic alterations are attributed for sure to the presence of these polyphenolic compounds.…”

Protective Effects of p-Coumaric Acid Isolated from Vaccinium bracteatum Thunb. Leaf Extract on Corticosterone-Induced Neurotoxicity in SH-SY5Y Cells and Primary Rat Cortical Neurons

“…Furthermore, p-coumaric acid is widely found in plants and exhibits protective effects via the MAP kinase family and Nrf2 signaling [7,32]. Moreover, it was recently reported that p-coumaric acid prevents obesity in brown adipose tissue mediated by the mTORC1/RPS6 pathways [33]. Thus, CREB activation could play an important role in the protective effects of NET-D1602 and p-coumaric acid against CORT-induced neurotoxicity in both SH-SY5Y cells and cortical neurons.…”