Oxygen Tension in the Human Maxillary Sinus Under Normal and Pathological Conditions

Aust, R; Drettner, B

doi:10.3109/00016487409126354

Cited by 102 publications

(38 citation statements)

References 3 publications

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“…Moreover, oxygen is taken up by the sinus mucosa 9 and may continue to fall as the ostium remains obstructed so that in chronic sinusitis oxygen levels of 0% have been found. 10 Therefore hypoxia might account for the plateau in NO accumulation observed in the obstructed sinus.…”

Section: Discussionmentioning

confidence: 99%

“…A likely candidate is hypoxia because when the sinuses are occluded their oxygen concentration falls and this is particularly so during infection when oxygen levels are also at their lowest. 9,10 Therefore it seemed possible that hypoxia might account for this limitation of NO accumulation as well as for the low NO concentrations observed in sinusitis. 11 In testing this hypothesis the nose was studied because of its accessibility.…”

Section: Introductionmentioning

confidence: 99%

“…9,10 The controlling mechanism that prevents NO rising further is not known. A likely candidate is hypoxia because when the sinuses are occluded their oxygen concentration falls and this is particularly so during infection when oxygen levels are also at their lowest.…”

Section: Introductionmentioning

confidence: 99%

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Hypoxia Depresses Nitric Oxide Output in the Human Nasal Airways

et al. 2000

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Objectives:The role of oxygen in the nasal air on nasal nitric oxide (NO) output was studied in 13 adult volunteers. Methods: Nasal NO was measured while air containing oxygen (0%-100% in nitrogen) was aspirated through the nasal airway before and after the topical application of xylometazoline. Results: The mean nasal NO output of the untreated nose was 507.8 ؎ 161.9 nL/min (mean ؎ SD) when 21% oxygen was aspirated through the nasal cavities in series and remained unaltered by 100% O 2 (P ‫؍‬ .79). Below 10% oxygen the reduction in nasal NO output correlated positively and significantly with the decrease in oxygen concentration (r 2 ‫؍‬ 0.14). NO output was 245.2 ؎ 153.4 nL/min at 0% oxygen, a significant decline from 21% oxygen (P < .0001). Nasal vasoconstriction induced by xylometazoline and alterations in the blood oxygen content by a maximal breath-holding or breathing 100% oxygen did not alter nasal NO in hypoxia (P ‫؍‬ .41). Conclusions: Nasal NO output is markedly depressed in hypoxia and is oxygen dependent at concentrations of less than 10%. Approximately 50% of nasally generated NO is produced from oxygen in nasal air or regulated by it.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Hypoxia Depresses Nitric Oxide Output in the Human Nasal Airways

et al. 2000

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“…However, persistent infection causes impairment of sinus ventilation, which creates an acidic anaerobic condition [6].…”

Section: Discussionmentioning

confidence: 99%

“…Eventually, ciliary damage and ineffective mucus clearance create a vicious circle [6]. Infection from extrinsic sources In 2010, Hong et al [7] immediately placed the implants in the left maxillary molar area after maxillary sinus membrane elevation using the lateral approach technique and bone graft using autograft and xenograft.…”

Section: Discussionmentioning

confidence: 99%

Functional Endoscopic Sinus Surgery for a Patient with Maxillary Sinusitis Occurring after Implant Placement

You¹,

Kim

Oh³

et al. 2013

The Journal Of Korean Association of Maxillofacial Plastic and

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Maxillary sinus membrane elevation and bone graft have been performed routinely in alveolar bone with insufficient residual bone height. There are a number of causes for development of maxillary sinusitis after these procedures. When maxillary sinusitis is caused by sinus membrane elevation, bone graft, and implant placement, various treatment such as medication, incision and drainage (I&D), implant removal, and the Caldwell-Luc procedure can be considered. Removal of an implant or the Caldwell-Luc procedure can be harmful if inflammation is not present in the oral cavity and survival of grafted bone and implant osseointegration can be expected despite the presence of maxillary sinusitis. In this case, functional endoscopic sinus surgery, which was often used in the otorhinolaryngology department, was performed without removal of the implant for a patient with maxillary sinusitis after one month following implant placement. Thus, we report on this case with a review of the literature.

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Bacteriology of Acute and Chronic Frontal Sinusitis

Brook¹

2002

Arch Otolaryngol Head Neck Surg

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Aspirates of 15 acutely and 13 chronically infected frontal sinuses were processed for aerobic and anaerobic bacteria. A total of 20 isolates (1.3 per specimen) were recovered from the 15 cases of acute frontal sinusitis, 16 aerobic and facultative isolates (1.1 per specimen) and 4 anaerobic isolates (0.3 per specimen). Aerobic and facultative organisms alone were recovered in 13 specimens (87%), and mixed aerobic and anaerobic bacteria were recovered in 2 (13%). The predominant aerobic and facultative organisms were Haemophilus influenzae (6), Streptococcus pneumoniae (5), and Moraxella catarrhalis (3). A total of 32 isolates were recovered from the 13 cases (2.5 per patient) of chronic frontal sinusitis, 12 aerobic and facultative isolates (0.9 per specimen) and 20 anaerobic isolates (1.5 per specimen). Aerobic and facultative organisms only were recovered in 3 instances (23%), anaerobes only in 7 instances (54%), and mixed aerobic and anaerobic bacteria in 3 instances (23%). The predominant aerobic bacteria were gram-negative bacilli (H influenzae, Klebsiella pneumoniae, and Pseudomonas aeruginosa). The predominant anaerobes included Prevotella species (8), Peptostreptococcus species (6), and Fusobacterium species (4). These findings illustrate the microbiologic features of acute and chronic frontal sinusitis.

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Oxygen Tension in the Human Maxillary Sinus Under Normal and Pathological Conditions

Cited by 102 publications

References 3 publications

Hypoxia Depresses Nitric Oxide Output in the Human Nasal Airways

Hypoxia Depresses Nitric Oxide Output in the Human Nasal Airways

Functional Endoscopic Sinus Surgery for a Patient with Maxillary Sinusitis Occurring after Implant Placement

Bacteriology of Acute and Chronic Frontal Sinusitis

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