Oxygen-generating alginate hydrogels as a bioactive acellular matrix for facilitating wound healing

Kang, Jeon Il; Park, Kyung Min; Парк, Ки Донг

doi:10.1016/j.jiec.2018.09.048

Cited by 68 publications

(31 citation statements)

References 41 publications

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“…190 These oxygen-loading nanomaterials can improve wound healing efficiency. Therefore, oxygenproducing biomaterials are essential to cure chronic diabetes wounds in the future [191][192][193][194] (Table 6).…”

Section: Oxygen Containing Nanocarriersmentioning

confidence: 99%

“…Lin et al used emulsion technique to prepare NaHS particles (NaHS@MPs), which could be used as in situ depot for continuous release of exogenous H 2 S under physiological conditions. 197 The sustained release of H 2 S from NaHS@MPs promotes several cell behaviors, including epidermal/endothelial cell proliferation and migration, as well as angiogenesis, by extending the activation of cellular ERK1/2 and p38, [181,[192][193][194] Sodium percarbonate PCL nanofibers scaffolds Continuously generating oxygen for up to 10 days [190] Sodium hydrosulfide NaHS@MPs NaHS@MPs sustained release of exogen-ous H2S under physiological conditions [197] Nitric oxide DNICs Continuous release of nitric oxide [201] submit your manuscript | www.dovepress.com…”

Section: Hydrogen Sulfide Containing Nanocarriersmentioning

confidence: 99%

See 1 more Smart Citation

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Bai¹,

Han²,

Dong³

et al. 2020

IJN

125

114

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Diabetic wound shows delayed and incomplete healing processes, which in turn exposes patients to an environment with a high risk of infection. This article has summarized current developments of nanoparticles/hydrogels and nanotechnology used for promoting the wound healing process in either diabetic animal models or patients with diabetes mellitus. These nanoparticles/hydrogels promote diabetic wound healing by loading bioactive molecules (such as growth factors, genes, proteins/peptides, stem cells/exosomes, etc.) and nonbioactive substances (metal ions, oxygen, nitric oxide, etc.). Among them, smart hydrogels (a very promising method for loading many types of bioactive components) are currently favored by researchers. In addition, nanoparticles/hydrogels can be combined with some technology (including PTT, LBL self-assembly technique and 3D-printing technology) to treat diabetic wound repair. By reviewing the recent literatures, we also proposed new strategies for improving multifunctional treatment of diabetic wounds in the future.

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Section: Oxygen Containing Nanocarriersmentioning

confidence: 99%

Section: Hydrogen Sulfide Containing Nanocarriersmentioning

confidence: 99%

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

Bai¹,

Han²,

Dong³

et al. 2020

IJN

125

114

View full text Add to dashboard Cite

show abstract

“…It is well known that an adequate concentration of H 2 O 2 is essential for various biological processes, while high concentrations (>62.5 µM) may induce serious damages to cells or organs (Meng et al 2015). Generation of H 2 O 2 is elevated with higher CaO 2 contents, ranging from 10 to 510 µM (0% to 1.8 wt%; Kang et al 2019). However, when catalase was added, the generation of H 2 O 2 could be effectively reduced from nearly 2000 µM when 2% CaO 2 was incorporated to an undetectable level (Newland et al 2017).…”

Section: Discussionmentioning

confidence: 99%

In Situ Oxygen Generation Enhances the SCAP Survival in Hydrogel Constructs

et al. 2021

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Prolonged and severe hypoxia is the main cause of death of transplanted cells prior to the establishment of functional circulation. In situ generation of oxygen by oxygen-producing scaffolds—a unique solution that could produce and deliver oxygen to the adjacent cells independently of blood perfusion—has attracted considerable attention to enhance the survivability of the transplanted cells. However, the application of oxygen-generating scaffolds for facilitating cell survival in pulp-like tissue regeneration is yet to be explored. In this study, gelatin methacryloyl (GelMA)—a biocompatible scaffolding material that closely mimics the native extracellular matrix and is conducive to cell proliferation and differentiation—was used to fabricate oxygen-generating scaffolds by loading various concentrations of CaO2. The CaO2 distribution, topography, swelling, and pore size of CaO2-GelMA hydrogels were characterized in detail. The release of O2 by the scaffold and the viability, spreading, and proliferation of stem cells from apical papilla (SCAPs) encapsulated in the GelMA hydrogels with various concentrations of CaO2 under hypoxia were evaluated. In addition, cellular constructs were engineered into root canals, and cell viability within the apical, middle, and coronal portions was assessed. Our findings showed that 0.5% CaO2-GelMA was sufficient to supply in situ oxygen for maintaining the embedded SCAP viability for 1 wk. Furthermore, the 0.5% CaO2-GelMA hydrogels improved the survivability of SCAPs within the coronal portion of the engineered cellular constructs within the root canals. This work demonstrated that 0.5% CaO2-GelMA hydrogels offer a potential promising scaffold that enhances survival of the embedded SCAPs in endodontic regeneration.

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“…For instance, in one study, Kang et al [31] could engineer a hydrogel-based reservoir that can generate oxygen. They synthesized a hydrogel made of Thiolated gelatin that was a hyperbaric oxygen-generating hydrogel which rapidly produces O2 up to the hyperoxia levels.…”

Section: Box 2 Tissue Engineeringmentioning

confidence: 99%

“…Apart from all the above, the oxygen releasing rate is a crucial factor to succeed in advanced wound healing. For instance, when oxygen is delivered too fast, the wound site is overload by oxygen, which leads to Bohr-effect (high concentration of oxygen for cells), and part of the Vacuum Negative pressure wound therapy [27] Exosome laden oxygen Antibacterial cryogel wound dressing OxOBand for diabetic and infectious wound healing [28] Photosynthetic sutures General wound healing [29] Topical oxygen treatment General wound healing [30] Oxygen-generating alginate hydrogel Facilitating wound healing [31] Oxygen delivery dressings Facilitating wound healing [32] Oxygen-generating film Local wound oxygenation [33] Metal-Organic Frameworks (MOFs) Bacterial infected wounds and environmental disinfection [34] MOFs Wound Healing [35] oxygen is wasted. On the other hand, if oxygen releasing occurs too slowly, low oxygen concentration results in cell death, wrong signals, and weak cellular functions.…”

Section: Box 2 Tissue Engineeringmentioning

confidence: 99%

Integration of microbubbles with biomaterials in tissue engineering for pharmaceutical purposes

Esmaeili

Rezaei

Beram

et al. 2020

Heliyon

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Tissue engineering with the aid of biomaterials is a novel and promising knowledge aiming at improving human life expectancy. Besides, microbubbles are increasingly employed in biomedical applications due to their capability as a reservoir of therapeutic agents and oxygen molecules. In the present study, Microbubbles as the backbone of the research are produced as one of the potent devices in tissue engineering approaches, including drug delivery, wound healing, 3D printing, and scaffolding. It was shown that microbubbles are capable of promoting oxygen penetration and boosting the wound healing process by supplying adequate oxygen. Microbubbles also demonstrated their strength and potency in advancing drug delivery systems by reinforcing mass transfer phenomena. Furthermore, microbubbles developed the mechanical and biological characteristics of engineered scaffolds by manipulating the pores. Increasing cell survival, the biological activity of cells, angiogenesis, cell migration, and also nutrient diffusion into the inner layers of the scaffold were other achievements by microbubbles. In conclusion, the interest of biomedical communities in simultaneous usage of microbubbles and biomaterials under tissue engineering approaches experiences remarkable growth in Pharmaceutical studies.

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Oxygen-generating alginate hydrogels as a bioactive acellular matrix for facilitating wound healing

Cited by 68 publications

References 41 publications

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

<p>Potential Applications of Nanomaterials and Technology for Diabetic Wound Healing</p>

In Situ Oxygen Generation Enhances the SCAP Survival in Hydrogel Constructs

Integration of microbubbles with biomaterials in tissue engineering for pharmaceutical purposes

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