Oxygen-carrying biomimetic nanoplatform for sonodynamic killing of bacteria and treatment of infection diseases

Geng, Xinyu; Chen, Yuhao; Chen, Zhiyi; Wei, Xianyuan; Dai, Yunlu; Yuan, Zhen

doi:10.1016/j.ultsonch.2022.105972

Cited by 20 publications

(8 citation statements)

References 43 publications

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“…For efficient sonodynamic action, a good supply of oxygen must be present to facilitate the production of ROS. In a study by Geng et al, modified ZIF-8 was loaded with a sonosensitiser, hematoporphyrin monomethyl ether (HMME) [ 101 ]. The MOF was further decorated with F127 (non-ionic surfactant, to improve hydrophobicity), and treated with haemoglobin to yield HFH@ZIF-8.…”

Section: Mofs As Antimicrobial Agentsmentioning

confidence: 99%

Metal–Organic Frameworks and Their Biodegradable Composites for Controlled Delivery of Antimicrobial Drugs

et al. 2023

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Antimicrobial resistance (AMR) is a growing global crisis with an increasing number of untreatable or exceedingly difficult-to-treat bacterial infections, due to their growing resistance to existing drugs. It is predicted that AMR will be the leading cause of death by 2050. In addition to ongoing efforts on preventive strategies and infection control, there is ongoing research towards the development of novel vaccines, antimicrobial agents, and optimised diagnostic practices to address AMR. However, developing new therapeutic agents and medicines can be a lengthy process. Therefore, there is a parallel ongoing worldwide effort to develop materials for optimised drug delivery to improve efficacy and minimise AMR. Examples of such materials include functionalisation of surfaces so that they can become self-disinfecting or non-fouling, and the development of nanoparticles with promising antimicrobial properties attributed to their ability to damage numerous essential components of pathogens. A relatively new class of materials, metal–organic frameworks (MOFs), is also being investigated for their ability to act as carriers of antimicrobial agents, because of their ultrahigh porosity and modular structures, which can be engineered to control the delivery mechanism of loaded drugs. Biodegradable polymers have also been found to show promising applications as antimicrobial carriers; and, recently, several studies have been reported on delivery of antimicrobial drugs using composites of MOF and biodegradable polymers. This review article reflects on MOFs and polymer–MOF composites, as carriers and delivery agents of antimicrobial drugs, that have been studied recently, and provides an overview of the state of the art in this highly topical area of research.

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Section: Mofs As Antimicrobial Agentsmentioning

confidence: 99%

Metal–Organic Frameworks and Their Biodegradable Composites for Controlled Delivery of Antimicrobial Drugs

et al. 2023

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“…The cause of the increase in drug-resistant bacteria is the irrational use of antibiotics [7]. Therefore, it is crucial to explore safe alternative treatment strategies, such as developing natural bactericidal agents to eradicate infections [8].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity and Inhibition Mechanism of Red Ginger (Zingiber officinale var. rubrum) Ethanol Extract Against Pathogenic Bacteria

Juariah

Bakar²,

Bakar³

et al. 2023

ARASET

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Pathogenic bacteria can interfere with the body health by producing toxic substances, damaging body tissues, multiplying and killing healthy body cells. Therefore, it is crucial to explore safe alternative treatment strategies, such as developing natural bactericidal agents to eradicate infections. Red ginger (Zingiber officinale var. rubrum) has potential as an antibacterial, so it is important to study its activity in inhibiting pathogenic bacteria. The aim of this study was to assess the antibacterial activity and inhibition mechanism of red ginger extract as an inhibitor of pathogenic bacterial infection. Methods such as dilution, Kirby-Bauer disc diffusion, and an inhibition test mechanism using a spectrophotometer and SEM were conducted in this study. Red ginger ethanol extract can inhibit the growth of Salmonela thypi, Staphylococcus epidermidis, and Streptococcus mutans at a concentration of 500 µg/mL, while Pseudomonas aeruginosa at a concentration of 250 µg/mL. Further observation of bacterial cell leakage showed that the higher the red ginger ethanol extract concentration, the higher the bacterial cell leakage. Based on SEM results, the quantity of S. thypi, S. epidermidis, and S. mutans after treatment with red ginger ethanol extract decreased, and the cell wall became wrinkled and destroyed. The ethanol extract of the red ginger rhizome can be recommended as a future antibacterial agent, especially for infections caused by pathogenic bacteria.

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“…To solve these problems, various nanocarriers, including polymeric micelles, nanoliposomes and inorganic nanoparticles, are developed to improve the concentration of organic sonosensitizers in tumor [21][22][23][24][25][26]. Although sonosensitizers loaded in nanocarriers have improved the antitumor effect of SDT to a certain degree in comparison to direct application of free sonosensitizers, accumulating evidence suggested that encapsulated sonosensitizers are not conducive to e cient SDT [27][28][29][30][31][32]. The hydrophobic sonosensitizers in nanocarriers lead to aggregation-caused uorescence quenching (ACQ) effect, impairing the generation of ROS when irradiated with US [33][34][35].…”

Section: Introductionmentioning

confidence: 99%

“…21–26 Although sonosensitizers loaded in nanocarriers have improved the antitumor effect of SDT to a certain degree in comparison to the direct application of free sonosensitizers, accumulating evidence suggested that encapsulated sonosensitizers are not conducive to efficient SDT. 27–32 The hydrophobic sonosensitizers in nanocarriers lead to aggregation-caused fluorescence quenching (ACQ) effect, impairing the generation of ROS when irradiated with US. 33–35 Contrary to the traditional organic sonosensitizers, it has been demonstrated that aggregation-induced emission luminogens (AIEgens) exhibited potent sonosensitivity in the aggregated state.…”

Section: Introductionmentioning

confidence: 99%

Tumor-targeted AIE polymeric micelles mediated immunogenic sonodynamic therapy inhibits cancer growth and metastasis

Deng

Zhao

et al. 2023

Nanoscale

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Oxygen-carrying biomimetic nanoplatform for sonodynamic killing of bacteria and treatment of infection diseases

Cited by 20 publications

References 43 publications

Metal–Organic Frameworks and Their Biodegradable Composites for Controlled Delivery of Antimicrobial Drugs

Metal–Organic Frameworks and Their Biodegradable Composites for Controlled Delivery of Antimicrobial Drugs

Antibacterial Activity and Inhibition Mechanism of Red Ginger (Zingiber officinale var. rubrum) Ethanol Extract Against Pathogenic Bacteria

Tumor-targeted AIE polymeric micelles mediated immunogenic sonodynamic therapy inhibits cancer growth and metastasis

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