945 Gastrointestinal: Enema nozzle injury to the rectum, a vague presentation with significant morbidity 946 Gastrointestinal: Gastric perforation during esophageal endoscopic submucosal dissection: A serious adverse event in a patient with esophageal stricture 947 Gastrointestinal: Idiopathic granulomatous gastritis observed by magnifying narrow-band imaging endoscopy 948 Hepatobiliary and Pancreatic: Unusual cause of acute pancreatitis 949 Gastrointestinal: Severe congestive heart failure and acute gastric mucosal necrosis Meta Analysis and Systematic Reviews 950 Systematic review: Current evidence in non-alcoholic fatty liver disease lacks relevance to patients with advanced fibrosis R Parker, J Hodson and IAC Rowe 957 Metformin use and the risk of colorectal adenoma: A systematic review and meta-analysis YS Jung, Reviews 966 Urgency to treat patients with chronic hepatitis C Clinical Gastroenterology 992 Inflammatory bowel disease detection and monitoring by measuring biomarkers in non-invasively collected colorectal mucus A Loktionov, V Chhaya, T Bandaletova and A Poullis 1003 Identifying the optimal strategy for screening of advanced colorectal neoplasia YS Jung, 1026 Do surveillance intervals in patients with more than five adenomas at index colonoscopy be shorter than those in patients with three to four adenomas? A Korean Association for the Study of Intestinal Experimental Gastroenterology 1040 Effects of argon plasma coagulation on human stomach tissue: An ex vivo study EJ Gong, Endoscopy 1046 Probe-based confocal laser endomicroscopy in the margin delineation of early gastric cancer for endoscopic submucosal dissection JC

Acute venous thrombosis is prevalent and potentially fatal. Accurate diagnosis of early thrombus is needed for patients in timely clinical intervention to prevent life-threatening conditions. Photoacoustic imaging (PAI) with excellent spatial resolution and high optical contrast shows more promise for this purpose. However, its application is dramatically limited by its signal-off effect on thrombus because of the ischemia in thrombus which lacks the endogenous photoacoustic (PA) signal of hemoglobin. To address this dilemma, we herein report the feasibility of using organic semiconducting nanoparticles (NPs) for contrast-enhanced PAI of thrombus in living mice. An organic semiconducting NP, self-assembled by amphiphilic perylene-3,4,9,10-tetracarboxylic diimide (PDI) molecules, is chemically modified with cyclic Arg-Gly-Asp (cRGD) peptides as a PA contrast agent (cRGD-PDI NPs) for selectively lightening early thrombus. cRGD-PDI NPs presents high PA intensity, good stability in light and serum, and sufficient blood-circulating half-life. In living mice, PA intensity of early thrombus significantly increases after tail vein injection of cRGD-PDI NPs, which is 4-fold greater than that of the control, blocking, and old thrombus groups. Pathological and immunohistochemical findings show that glycoprotein IIb/IIIa abundant in early thrombus is a good biomarker targeted by cRGD-PDI NPs for distinguishing early thrombus from old thrombus by PAI. Such a lightening PAI effect by cRGD-PDI NPs successfully provides accurate information including the profile, size and conformation, and spatial distribution of early thrombus, which may timely monitor the obstructive degree of thrombus in blood vessels and the thrombolysis effect.

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In a finite elements simulated type C pelvic ring disruption (bilateral type Denis II sacral fracture), the breakage risk of screws fixed in double-segment bilaterally symmetrically is low, and the breakage risk of screws fixed in S2 segment is lower than that of S1 segment. The bilaterally symmetrical screw fixation in double-segment is strongly recommended to reduce the breakage risk of screws. In addition, the breakage risk of lengthened screws is lower than that of ordinary screws except when screws are fixed in only S2 segment, which merits attention.