Oxidized low-density lipoprotein, iron stores, and haptoglobin polymorphism

Brouwers, Annelies; Langlois, Michel; Delanghe, Joris; Billiet, Johan; Buyzere, Marc De; Vercaemst, R.; Rietzschel, Ernst; Bernard, Dirk; Blaton, V.

doi:10.1016/j.atherosclerosis.2004.05.005

Cited by 50 publications

(45 citation statements)

References 30 publications

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“…The observed differences in free Hb between Hp phenotypes could help to explain the previously reported differences in oxidative stress markers among Hp phenotypes (3,10 ).…”

Section: Serum Free Hemoglobin Concentrations In Healthy Individuals mentioning

confidence: 59%

Serum Free Hemoglobin Concentrations in Healthy Individuals Are Related to Haptoglobin Type

Ouyang

Taes

et al. 2005

Clinical Chemistry

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“…The observed differences in free Hb between Hp phenotypes could help to explain the previously reported differences in oxidative stress markers among Hp phenotypes (3,10 ).…”

Section: Serum Free Hemoglobin Concentrations In Healthy Individuals mentioning

confidence: 59%

Serum Free Hemoglobin Concentrations in Healthy Individuals Are Related to Haptoglobin Type

Ouyang

Taes

et al. 2005

Clinical Chemistry

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“…Diabetic complications were strongly associated with Hp 2-2 and Hp 2-1, Hp 1-1, Hp 2-1 M, in a decreasing order in this study. The reasons for this could be due to (i) differences in Hb binding capacities of the different Hp phenotypes [47]; (ii) the shape and size of the Hp phenotypes [17]; (iii) an increase in redox active iron in the plasma of humans with the Hp 2-2 phenotype [48]; (iv) the ''clearance'' of Hp-Hb complex in the blood circulation after intravascular haemolysis by CD163 which is less effective in Hp 2-2 individuals [23]; and (v) the better antioxidant effects of Hp 1-1 phenotypes on low-density lipoprotein (LDL) oxidation than Hp 2-2 [49,50]. These may explain the susceptibility of Hp 2-2 individuals to complications such as coronary artery diseases (CAD), neuropathy, nephropathy and hypertension.…”

Section: Discussionmentioning

confidence: 99%

Haptoglobin Polymorphism and Association with Complications in Ghanaian Type 2 Diabetic Patients

et al. 2011

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There is scanty information on the role of genetic factors, especially those relating to haptoglobin (Hp) phenotypes in the expression of complications among diabetes mellitus patients in Ghana. In this study, we investigated whether there is any association between Hp phenotypes and diabetic complications and to determine if association of the Hp phenotypes with diabetic complications in Ghanaian diabetics differ from those in Caucasians. A total of 398 participants were randomly recruited into the study. These comprised diabetic patients numbering 290 attending a diabetes Clinic in Ghana and 108 non-diabetic controls from the same community. Analyses of the results indicate that most of the diabetics with complications were of the Hp 2-2 (35%) and Hp 2-1 (23.9%) phenotypes. Fewer diabetics were found to be of the Hp 2-1 M phenotype. The controls were mostly of Hp 1-1 and Hp 2-1 M phenotypes. The odds ratio of having complications in a diabetic with an Hp 2-2 phenotype was 18.27 times greater than that for Hp 0-0. Hp 2-2 phenotype with its poor antioxidant activity may therefore be a useful predictor for the propensity of an individual to develop diabetes complications.

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“…In a subpopulation of Asklepios participants, the serum ox-LDL test was analytically validated, and values correlated positively with lipid peroxides in plasma as measured by liquidchromatographic separation of thiobarbituric acid-reactive malondialdehyde. 16 We could also demonstrate previously that ox-LDL was associated with shortening of peripheral blood leukocyte telomere length, a putative marker of biological aging. 43 Alternative reasons for the small effect size are that the myocardium might be relatively preserved from, or better defended against, oxidative stress, or that the echographic measures used might not have been sensitive enough.…”

Section: Study Limitationsmentioning

confidence: 82%

“…Serum oxidized low-density lipoprotein concentration was measured by a sandwich ELISA (Mercodia). 7,8,16 …”

Section: Biochemical Analysesmentioning

confidence: 99%

Oxidized Low-Density Lipoprotein Cholesterol Is Associated With Decreases in Cardiac Function Independent of Vascular Alterations

Rietzschel

Langlois²,

Buyzere³

et al. 2008

Hypertension

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Abstract-In contrast to the plethora of vasculopathies to which oxidized low-density lipoprotein cholesterol (ox-LDL) can be linked, there are no data linking ox-LDL to myocardial (dys)function in the community. We tested whether ox-LDL, a marker of oxidative stress, was linked to early cardiac structural and functional damage in the general population. The Asklepios Study is a random sample of 2524 male and female volunteers, comparable to the Belgian population between 35 and 55 years free from overt cardiovascular disease. Cardiac morphology, systolic, and early and late diastolic tissue Doppler mitral annulus velocities were recorded during an echocardiography, followed by a vascular examination (carotid and femoral arteries). Serum ox-LDL was measured by sandwich ELISA using the mAb-4E6 monoclonal antibody. Effects of ox-LDL were assessed after adjustment for age, gender, lipid fractions, blood pressure, heart rate, height, weight, glycemia, smoking, and drug treatment. Mean ox-LDL was 96.0Ϯ38.9 U/L. After adjustment, increasing ox-LDL levels were associated with a more spherical left ventricular cavity (minor/major axis dimensions; PϽ0.001) and decreasing diastolic (early diastolic tissue Doppler mitral annulus velocity; PϽ0.001, more pronounced in women) and systolic function (amplitude of systolic tissue Doppler mitral annulus velocity; Pϭ0.008, more pronounced in men). These results remained unaffected when further adjustments were made for inflammatory markers, lifestyle, or vascular damage (atherosclerosis and arterial stiffening). These results are the first "proof of concept" that ox-LDL impacts cardiac structure and function at a community level, independent of classic risk factors, lifestyle, inflammation, and prevalent vascular damage. Our data suggest that ox-LDL is a risk marker for early ventricular remodelling. However, the effect size in the general population is small. (Hypertension. 2008;52:535-541.)

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Oxidized low-density lipoprotein, iron stores, and haptoglobin polymorphism

Cited by 50 publications

References 30 publications

Serum Free Hemoglobin Concentrations in Healthy Individuals Are Related to Haptoglobin Type

Serum Free Hemoglobin Concentrations in Healthy Individuals Are Related to Haptoglobin Type

Haptoglobin Polymorphism and Association with Complications in Ghanaian Type 2 Diabetic Patients

Oxidized Low-Density Lipoprotein Cholesterol Is Associated With Decreases in Cardiac Function Independent of Vascular Alterations

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