Oxidative Stress Responses to <i>Nigella sativa</i> Oil Concurrent with a Low‐Calorie Diet in Obese Women: A Randomized, Double‐Blind Controlled Clinical Trial

Namazi, Nazli; Mahdavi, Reza; Alizadeh, Mohammad; Farajnia, Safar

doi:10.1002/ptr.5417

Cited by 52 publications

(52 citation statements)

References 28 publications

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“…In contrast, Namazi et al showed that consumption of N. sativa oil with a low‐calorie diet caused reduction in the hs‐CRP and TNFα levels. However similar to the current study, MDA and IL‐6 levels did not change in their study (Mahdavi et al, ; Namazi, Mahdavi, Alizadeh, & Farajnia, ). Differences in prescribed dosage and form of N. sativa , clinical conditions of the patients and baseline inflammatory parameters can justify inconsistency with the result of the present study.…”

Section: Discussionsupporting

confidence: 85%

The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients: A pilot study

Alizadeh‐naini

Yousefnejad

Hejazi

2020

Phytotherapy Research

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The aim of this study was to evaluate the effects of Nigella sativa (N. sativa) in addition to quadruple‐therapy on Helicobacter pylori eradication, dyspepsia, biochemical‐markers, and quality of life in infected patients. In this double‐blind placebo‐controlled clinical‐trial, 51 H. pylori infected patients with functional dyspepsia were randomly assigned to treatment (quadruple‐therapy with 2 g/day N. sativa) or placebo groups (quadruple‐therapy with 2 g/day placebo) for 8 weeks. Serum levels of interleukin‐8 (IL‐8), high‐sensitivity C‐reactive protein (hs‐CRP) and malondialdehyde, quality of life, dyspepsia, food‐intake, body‐weight, and body mass index (BMI) were evaluated at the baseline and at the end of the study. H. pylori eradication was evaluated at the end of the intervention. At the end of the study, H. pylori eradication was more in the N. sativa group compared with the placebo (p = .01). Weight, BMI, and dietary‐intake (p < .05) increased significantly as compared with placebo. A significant improvement was also observed in patients' quality of life in the treatment group compared with the placebo (p < .05). The differences of biochemical‐markers and dyspepsia between the two groups were not significant. So, N. sativa supplementation with medical treatment may have beneficial effects on H. pylori eradication, weight, BMI, dietary‐intake, and quality of life in infected patients.

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Section: Discussionsupporting

confidence: 85%

The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients: A pilot study

Alizadeh‐naini

Yousefnejad

Hejazi

2020

Phytotherapy Research

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“…Some RCTs demonstrated that NS oil in combination with a low-calorie diet decreased weight in obese women in comparison to the placebo level [61, 62]. It also caused the superoxide dismutase (SOD) level to be elevated [61] and the TG and the LDL-C levels to be decreased [62]. …”

Section: Resultsmentioning

confidence: 99%

Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

Mahdian²,

et al. 2017

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ObjectivesNigella sativa (black seed or black cumin), which belongs to the Ranunculacea family, is an annual herb with many pharmacological properties. Among its many active constituents, thymoquinone (TQ) is the most abundant constituent of the volatile oil of Nigella sativa (N. sativa) seeds, and it is the constituent to which most properties of this herb are attributed.MethodsPubMed-Medline, Scopus, and Web of Science databases were searched to identify randomized control trials (RCTs) investigating the therapeutic effects of N. sativa and/or TQ. In this review, we investigated the clinical uses of N. sativa and TQ in the prevention and the treatment of different diseases and morbidity conditions in humans.ResultsBlack seed and TQ are shown to possess multiple useful effects for the treatment of patients with several diseases, such as inflammatory and auto-immune disorders, as well as metabolic syndrome. Also, other advantages, including antimicrobial, anti-nociceptive and anti-epileptic properties, have been documented. The side effects of this herbal medicine appear not to be serious, so it can be applied in clinical trials because of its many advantages.ConclusionSome effects of N. sativa, such as its hypoglycemic, hypolipidemic and bronchodilatory effects, have been sufficiently studied and are sufficiently understood to allow for the next phase of clinical trials or drug developments. However, most of its other effects and applications require further clinical and animal studies.

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“…Clinical trials using NS oil in chronic disorders have reported controversial results. A low‐calorie diet with 3 g/day NS oil for 8 weeks resulted in no significant changes in TAC levels of obese women (Namazi, Mahdavi, Alizadeh, & Farajnia, ); reversely, a similar study showed that a low‐calorie diet plus 3 g/day of NS oil decreased serum levels of TNF‐α and hs‐CRP in obese women (Mahdavi, Namazi, Alizadeh, & Farajnia, ). Moreover, 3 months administration of 450‐mg NS oil three times per day improved TAC level in patients with hepatitis C (Barakat, El Wakeel, & Hagag, ).…”

Section: Discussionmentioning

confidence: 97%

The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis

Nikkhah-Bodaghi

Darabi

Agah

et al. 2019

Phytotherapy Research

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The aim of this study was to evaluate the effects of Nigella sativa (NS) supplementation in patients with ulcerative colitis. Two grams of NS powder or placebo were consumed for 6 weeks by 46 patients with active mild to moderate ulcerative colitis.Using valid and common questionnaires of colitis severity and blood sampling, we estimated disease activity index, quality of life, and some of inflammatory and oxidative stress factors at baseline and after 6 weeks of supplementation. NS-elevated tumor necrosis factor-alpha and high-sensitivity-c-reactive-protein as well as reduced malondialdehyde (p = 0.01, p = 0.02, and p = 0.005, respectively) compared with placebo. There was no significant difference between the two groups in serum total antioxidant capacity and nuclear factor kB levels. Total scores of Simple Clinical Colitis Activity Index Questionnaire and Inflammatory Bowel Disease Questionnaire-9were not different between the two groups; however, stool frequency score decreased significantly in NS group. Further clinical trials with different pattern of NS administration (the amount of total and divided daily doses, either powder type or standard extracts/oil and different time arrangement) are needed to clarify the vision.

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Oxidative Stress Responses to Nigella sativa Oil Concurrent with a Low‐Calorie Diet in Obese Women: A Randomized, Double‐Blind Controlled Clinical Trial

Cited by 52 publications

References 28 publications

The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients: A pilot study

The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients: A pilot study

Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

The effects of Nigella sativa on quality of life, disease activity index, and some of inflammatory and oxidative stress factors in patients with ulcerative colitis

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