The beneficial health effects of Nigella sativa on Helicobacter pylori eradication, dyspepsia symptoms, and quality of life in infected patients: A pilot study

Abstract

The aim of this study was to evaluate the effects of Nigella sativa (N. sativa) in addition to quadruple‐therapy on Helicobacter pylori eradication, dyspepsia, biochemical‐markers, and quality of life in infected patients. In this double‐blind placebo‐controlled clinical‐trial, 51 H. pylori infected patients with functional dyspepsia were randomly assigned to treatment (quadruple‐therapy with 2 g/day N. sativa) or placebo groups (quadruple‐therapy with 2 g/day placebo) for 8 weeks. Serum levels of interleukin‐8 (IL‐8), high‐sensitivity C‐reactive protein (hs‐CRP) and malondialdehyde, quality of life, dyspepsia, food‐intake, body‐weight, and body mass index (BMI) were evaluated at the baseline and at the end of the study. H. pylori eradication was evaluated at the end of the intervention. At the end of the study, H. pylori eradication was more in the N. sativa group compared with the placebo (p = .01). Weight, BMI, and dietary‐intake (p < .05) increased significantly as compared with placebo. A significant improvement was also observed in patients' quality of life in the treatment group compared with the placebo (p < .05). The differences of biochemical‐markers and dyspepsia between the two groups were not significant. So, N. sativa supplementation with medical treatment may have beneficial effects on H. pylori eradication, weight, BMI, dietary‐intake, and quality of life in infected patients.

Effect of Nigella sativa on Selected Gastrointestinal Diseases

“…The H. pylori eradication rate was significantly increased in the NS group compared with the placebo group ( p = 0.01). After the intervention, 45.45% (n = 10) of participants were still H. - pylori -positive in the placebo group compared with 12.5% (n = 3) in the NS group [ 94 ].…”

Black Seeds

“…However, much additional work must be done to confirm these effects. These trials examined suppression of Helicobacter pylori infections and dyspepsia, [147][148][149][150][151] parasitic, bacterial and human immunodeficiency virus infections, [152][153][154][155][156][157] hepatitis C symptoms, 158,159 and Candida albicans-induced vaginitis. 160 Other initial findings suggest that NS oil 161 and TQ 162 have potential to relieve SARS-2-COVID symptoms.…”

Nocebo response intensity and influencing factors in the randomized clinical trials of functional dyspepsia: A systematic review and meta‐analysis

“…The average rate of nasopharyngitis among the studies was 9.3% (41/442), as reported by Matsueda et al 26 The average rate of constipation was 6% (95% CI 1%-10%; P < 0.01), including 31 patients in eight studies 15,16,18,19,22,24,28,32 (Figure 4A). The average rate of headache was 5% (95% CI 3%-8%; P = 0.02), with 11 studies 12,14,18,[20][21][22][23]25,34,35,37 including 36 patients (Figure 4B). While the average rate of diarrhea was 3% (95% CI 1%-4%; P < 0.01), with 10 studies 12,14,18,19,21,22,25,26,29,37 including 48 patients (Figure 4C).…”