Oxidative stress-related parameters in prostate of rats with experimental autoimmune prostatitis

Orsilles, Miguel Ángel; Depiante-Depaoli, M

doi:10.1002/(sici)1097-0045(19980301)34:4<270::aid-pros4>3.0.co;2-l

Cited by 22 publications

(4 citation statements)

References 20 publications

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“…It is important to note that antigenic immunity can occur within a species or among species. Prostate tissue from mice or rats can be extracted to induce autoimmune disorders in the same species of mice or rats ( 49 – 53 , 60 – 63 , 67 , 69 , 75 ), and prostate tissue from rats can also be used to induce other species of mice ( 35 , 36 , 56 , 58 , 59 , 68 ). Both methods can induce prostatitis.…”

Section: Non-bacterial Prostatitis Modelsmentioning

confidence: 99%

Preclinical models and evaluation criteria of prostatitis

Luo

et al. 2023

Front. Immunol.

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Prostatitis is a common urological condition that affects almost half of all men at some point in their life. The prostate gland has a dense nerve supply that contributes to the production of fluid to nourish sperm and the mechanism to switch between urination and ejaculation. Prostatitis can cause frequent urination, pelvic pain, and even infertility. Long-term prostatitis increases the risk of prostate cancer and benign prostate hyperplasia. Chronic non-bacterial prostatitis presents a complex pathogenesis, which has challenged medical research. Experimental studies of prostatitis require appropriate preclinical models. This review aimed to summarize and compare preclinical models of prostatitis based on their methods, success rate, evaluation, and range of application. The objective of this study is to provide a comprehensive understanding of prostatitis and advance basic research.

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Section: Non-bacterial Prostatitis Modelsmentioning

confidence: 99%

Preclinical models and evaluation criteria of prostatitis

Luo

et al. 2023

Front. Immunol.

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“…Moreover, a humoral and cellular prostate‐specific immune response can be detected systemically and locally [57]. Upregulated mast cell degranulation, cytotoxic T lymphocytes and pathogenic reactive oxygen intermediates released by macrophages have been identified in autoimmune rats and are probably responsible for the tissue alterations observed on histological sections [54, 59, 60] (Table 1). Prostatein or rat prostatic steroid‐binding protein (PSBP), a member of the secretoglobin superfamily, has been identified as the major autoantigen in our rat model of EAP [61].…”

Section: Current Animal Models For Autoimmune Cp/cppsmentioning

confidence: 99%

Autoimmune Prostatitis: State of the Art

et al. 2007

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The prostate is one of the main male sex accessory glands and the target of many pathological conditions affecting men of all ages. Pathological conditions of the prostate gland range from infections, chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) of a still unknown aetiology to benign hyperplasia and cancer. CP/CPPS is one of the most prevalent diseases in the urologic clinic and affects men younger than 50 years old. A significant advance in the understanding of CP/CPPS was made when an autoimmune response against prostate antigens was revealed in a considerable number of patients. During the last 30 years, extensive work has been done regarding the development and characterization of different rodent models of experimental autoimmune prostatitis (EAP). It has been demonstrated that tolerance to prostate antigens can be disrupted in some strains of rats and mice and cellular and humoral responses to prostate antigens are elicited. A Th1 pattern has been described and the cellular response seems to be the major pathogenic mechanism involved. Immune cells infiltrate the gland and induce prostate lesions. The genetic background and hormonal imbalance are factors that could contribute to the onset of the disease in susceptible young males. Moreover, spontaneous autoimmune prostatitis could also occur with advanced age in susceptible strains. In this review, we summarize the current knowledge regarding rodent models of EAP and the immunological alterations present in CP/CPPS patients. We also discuss the reliability of these experimental approaches as genuine tools for the study of human disease.

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“…Therefore, oligonol is expected to have an influence on GPx activation rather than SOD activation in the antioxidant process. According to studies on the relation between oxidative stress and prostatitis, decrease of catalase activity and increase of lipid peroxidation were observed in rats with autoimmune prostatitis 26. Additionally, decreased activity of anti-oxidative enzymes was reported in patients with chronic bacterial prostatitis 27…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of Oligomerized Polyphenol on Estradiol-Induced Prostatitis in Rats

et al. 2009

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PurposeChronic prostatitis/chronic pelvic pain syndrome (CP/CPPS, NIH category III) accounts for 90-95% of prostatitis cases. However, standard treatment has not yet been established. It is known that polyphenols have an inhibitory effect on inflammation by their antioxidative capacity, and oligonol, a polyphenol derivative, has much higher bioavailability and bioactivity than common polyphenols. We investigated the anti-inflammatory effects and mechanisms of oligonol in estradiol-induced prostatitis rat models.Materials and MethodsProstatitis was induced by 17 beta-estradiol (E2) and dihydrotestosterone (DHT) in Wistar male rats (n = 20). Ten rats were placed in the oligonol-treated group and 10 in the E2 + DHT-treated group. The other 10 rats were also included as normal control group. Oligonol (60 mg/kg/day) was administered via gavage tube for 4 weeks. Superoxide dismutase (SOD), glutathione peroxidase (GPx), and tumor necrosis factor-alpha (TNF-α) were quantified, and phosphorylation of IκBa and histological changes were also evaluated in prostatic tissue.ResultsThe SOD and GPx activity showed tendencies to increase in the oligonol-treated group compared to the normal control group. TNF-α expression was slightly reduced in the oligonol-treated group. Western blotting demonstrated that phosphorylation of IκBa in the oligonol-treated group was significantly lower than in the normal control group. The E2 + DHT-treated group revealed severe atrophy of acinar epithelial cells and infiltration of leukocytes and lymphocytes in the prostate, however, the oligonol-treated group showed overall reduction in inflammatory features.ConclusionThis study demonstrates that oligonol improves estradiol-induced non-bacterial prostatitis by regulating phosphorylation of IκBa. These findings suggest that oligonol has a beneficial effect on prevention and treatment of CP/CPPS.

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Oxidative stress-related parameters in prostate of rats with experimental autoimmune prostatitis

Cited by 22 publications

References 20 publications

Preclinical models and evaluation criteria of prostatitis

Preclinical models and evaluation criteria of prostatitis

Autoimmune Prostatitis: State of the Art

Preventive Effects of Oligomerized Polyphenol on Estradiol-Induced Prostatitis in Rats

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