Oxidative Stress Mechanisms and their Modulation

Bansal, M. P.; Kaushal, Naveen

doi:10.1007/978-81-322-2032-9

Cited by 22 publications

(29 citation statements)

References 309 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…ROS can directly or indirectly regulate the activity of redox factor‐1 (Ref‐1) by targeting Cys‐65 of Ref‐1 and target active activator protein‐1 (AP‐1), p53, nuclear factor‐kappa beta (NF‐κβ), hypoxia‐inducible factor (HIF‐1α), Nrf2 and other TFs. These activated TFs further delicately manipulate the “on” and “off” switches of target genes . Various human bZIP TFs have been demonstrated to be regulated in a redox‐dependent manner by Ref‐1 …”

Section: Ros Specificity and Selectivitymentioning

confidence: 99%

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Huang

2019

Acta Physiologica

View full text Add to dashboard Cite

Oxidative stress is recognized as free radical dyshomeostasis, which has damaging effects on proteins, lipids and DNA. However, during cell differentiation and proliferation and other normal physiological processes, free radicals play a pivotal role in message transmission and are considered important messengers. Organisms maintain free radical homeostasis through a sophisticated regulatory system in which these "2faced" molecules play appropriate roles under physiological and pathological conditions. Reactive oxygen species (ROS), including a large number of free radicals, act as redox signalling molecules in essential cellular signalling pathways, including cell differentiation and proliferation. However, excessive ROS levels can induce oxidative stress, which is an important risk factor for diabetes, cancer and cardiovascular disease. An overall comprehensive understanding of ROS is beneficial for understanding the pathogenesis of certain diseases and finding new therapeutic treatments.This review primarily focuses on ROS cellular localization, sources, chemistry and molecular targets to determine how to distinguish between the roles of ROS as messengers and in oxidative stress. K E Y W O R D Shomeostasis, oxidative stress, reactive oxygen, redox signalling, signalling pathways 2 of 16 | HUANG ANd LI for the development of new therapeutic strategies for cancer and cardiovascular disease. | SOURCES AND PHYSICOCHEMICAL PROPERTIES OF ROS | ROS sourcessecond messengers, what are the corresponding acceptors for these special ROS? To better recognize ROS, a new tool that can monitor changes in ROS levels and position in real time must be developed. Determining how to utilize the characteristics of ROS to treat diseases, such as cardiovascular disease, diabetes, autoimmune diseases, cancer and Alzheimer's diseases, is worth further exploration.

show abstract

Section: Ros Specificity and Selectivitymentioning

confidence: 99%

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Huang

2019

Acta Physiologica

View full text Add to dashboard Cite

show abstract

“…Free radicals are called the reactive oxygen species (ROS), and they also include a subgroup of reactive nitrogen species (RNS) which are the products of normal cellular metabolism. Overwhelming production of these molecules leads to oxidative stress damage to lipids, proteins and DNA [4].…”

Section: Stress Mechanism and Oxidative-antioxidative Balancementioning

confidence: 99%

Stress, Natural Antioxidants and Future Perspectives

Seyidoğlu¹,

Aydin²

2020

The Health Benefits of Foods - Current Knowledge and Further Development

View full text Add to dashboard Cite

Stress can exist by a variety of daily challenges related to obesity, other eating disorders, long-term health issues and immune system suppression. Free radicals derived from oxygen, called reactive oxygen species, reactive nitrogen species and similarly antioxidants are part of the body's natural functioning. Oxidative stress occurs when free radicals and antioxidants are out of balance. The prooxidantantioxidant balance is assessed by determination of both oxidant and antioxidant status, which can be measured simultaneously in blood and tissue. Dietary or natural antioxidants play an important role in helping the endogenous antioxidants in scavenging the excess of free radicals. Antioxidant supplements include several important substances such as beta carotene, lutein, phycocyanin and zeaxanthin, which are rich in vegetables, fruits and natural foods. All these contents have a key role in growth, immunity and lifetime quality. Still, high dose of the natural foods can cause the organism, not to assimilate the wastes by the mechanism. In this chapter, we'll inquire to explain the oxidative and antioxidative mechanisms and balance via importance of the natural antioxidants to life quality. For this purpose, oxidative stress, related diseases, antioxidants and their importance will be reviewed, and the correlation between natural antioxidants and health will be presented.

show abstract

“…Scavengers guarantee the balance between the production of free radicals and the rate of their removal. (273). Alpha-lipoic acid acts directly and indirectly as a scavenger of free radicals including, singlet oxygen, superoxide, peroxyl radicals, and the breakdown radicals of peroxynitrite (232).…”

Section: Environmental Medicine Treatmentsmentioning

confidence: 99%

“…They interact with exogenous dietary and/or synthetic AO (carotenoids, retinoids, flavonoids, polyphenols, glutathione, ascorbic acid, tocopherols). The complex regulation and use of these substances is the therapeutic challenge(232,273).-Regulation of intestinal dysfunctionEndogenous and exogenous scavengers act synergistically to maintain the redox homeostasis. Therefore, dietary or natural antioxidants play an important role to stabilize this interaction.…”

mentioning

confidence: 99%

EUROPAEM EMF Guideline 2016 for the prevention, diagnosis and treatment of EMF-related health problems and illnesses

Belyaev

Dean

Eger

et al. 2016

Reviews on Environmental Health

152

View full text Add to dashboard Cite

Chronic diseases and illnesses associated with non-specific symptoms are on the rise. In addition to chronic stress in social and work environments, physical and chemical exposures at home, at work, and during leisure activities are causal or contributing environmental stressors that deserve attention by the general practitioner as well as by all other members of the health care community. It seems necessary now to take "new exposures" like electromagnetic fields (EMF) into account. Physicians are increasingly confronted with health problems from unidentified causes. Studies, empirical observations, and patient reports clearly indicate interactions between EMF exposure and health problems. Individual susceptibility and environmental factors are frequently neglected. New wireless technologies and applications have been introduced without any certainty about their health effects, raising new challenges for medicine and society. For instance, the issue of so-called non-thermal effects and potential long-term effects of low-dose exposure were scarcely investigated prior to the introduction of these technologies. Common electromagnetic field or EMF sources: Radio-frequency radiation (RF) (3 MHz to 300 GHz) is emitted from radio and TV broadcast antennas, Wi-Fi access points, routers, and clients (e.g. smartphones, tablets), cordless and mobile phones including their base stations, and Bluetooth devices. Extremely low frequency electric (ELF EF) and magnetic fields (ELF MF) (3 Hz to 3 kHz) are emitted from electrical wiring, lamps, and appliances. Very low frequency electric (VLF EF) and magnetic fields (VLF MF) (3 kHz to 3 MHz) are emitted, due to harmonic voltage and current distortions, from electrical wiring, lamps (e.g. compact fluorescent lamps), and electronic devices. On the one hand, there is strong evidence that long-term exposure to certain EMFs is a risk factor for diseases such as certain cancers, Alzheimer's disease, and male infertility. On the other hand, the emerging electromagnetic hypersensitivity (EHS) is more and more recognized by health authorities, disability administrators and case workers, politicians, as well as courts of law. We recommend treating EHS clinically as part of the group of chronic multisystem illnesses (CMI), but still recognizing that the underlying cause remains the environment. In the beginning, EHS symptoms occur only occasionally, but over time they may increase in frequency and severity. Common EHS symptoms include headaches, concentration difficulties, sleep problems, depression, a lack of energy, fatigue, and flu-like symptoms. A comprehensive medical history, which should include all symptoms and their occurrences in spatial and temporal terms and in the context of EMF exposures, is the key to making the diagnosis. The EMF exposure is usually assessed by EMF measurements at home and at work. Certain types of EMF exposure can be assessed by asking about common EMF sources. It is very important to take the individual susceptibility into account. The primary method of trea...

show abstract

Oxidative Stress Mechanisms and their Modulation

Cited by 22 publications

References 309 publications

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Physiological regulation of reactive oxygen species in organisms based on their physicochemical properties

Stress, Natural Antioxidants and Future Perspectives

EUROPAEM EMF Guideline 2016 for the prevention, diagnosis and treatment of EMF-related health problems and illnesses

Contact Info

Product

Resources

About