Oxidative Stress Marker and Pregnancy Induced Hypertension

Abstract

Background:Pregnancy induced hypertension (PIH) is a state of extremely increased oxidative stress. Hence, research and test of role and significance of oxidative stress in hypertensive disturbance in pregnancy is very important.Aim:Aims of this research were to determine a level of thiobarbituric acid reactive substance (TBARS) as oxidative stress marker in blood of pregnant woman with pregnancy induced hypertension and to analyze correlation of TBARS values with blood pressure values in pregnancy induced hypertensive pregnant women.Patients and methods:Research has been performed at the Clinic of Gynecology and Obstetrics, University Clinical Centre in the Republic of Srpska. It covered 100 pregnant women with hypertension and 100 healthy pregnant women of gestation period from 28 to 40 weeks. Level of TBARS is determined as an equivalent of malondialdehyde standard, in accordance with recommendations by producer (Oxi Select TBARS Analisa Kit).Results:Pregnancy induced hypertension is a state of extremely increased oxidative stress. All pregnant women experiencing hypertension had increased TBARS values in medium value interval over 20 µmol, 66%, whereas in group of healthy pregnant women, only 1% experienced increased TBARS value. Pregnant women with difficult preeclampsia (32%) had high TBARS values, over 40 µmol, and with mild PIH, only 4.9% pregnant women.Conclusion:Pregnant women with pregnancy induced hypertension have extremely increased degree of oxidative stress and lipid peroxidation. TBARS values are in positive correlation with blood pressure values, respectively the highest TBARS value were present in pregnant women with the highest blood pressure values.

Supplementing punicalagin reduces oxidative stress markers and restores angiogenic balance in a rat model of pregnancy-induced hypertension

“…Oxidative stress plays a critical role in the pathophysiology of PE [ 49 ]. The data reveal an increase in oxidative stress in patients with PE, as well as in animal models of PE [ 50 51 52 53 54 55 ].…”

Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction

“…The elevated level of OS markers such as MDA and 8hydroxy-2 ′ -deoxyguanosine (8-OHdG) and the decreased level of total antioxidant capacity were described by several 4 Oxidative Medicine and Cellular Longevity researchers [11,15,20,37]. Data on the pregnancy-induced hypertension is rare [21][22][23][24], but it also suggests the occurrence of OS. It should be highlighted that the comparison of OS between two groups of patients is challenging.…”

“…It was shown that preeclampsia is associated with high levels of malondialdehyde (MDA), xanthine oxidase, and glutathione peroxidase and decreased levels of total antioxidant capacity and glutathione [6][7][8][9]. However, data on pathologies such as PIH [21][22][23][24] or IUGR [10][11][12] are rare.…”

Effectiveness and safety of Compound Danshen injection as treatment for pregnancy-induced hypertension: A metaanalysis

“…A large-scale study found that the probability of maternal death in mothers diagnosed with PIH after pregnancy was significantly higher than that in normal pregnant women [20]. In addition, PIH is often combined with a number of other disease conditions such as pulmonary edema and liver dysfunction, which also increase the risk of pregnancy-related death [21,22]. With incidence of 9 % and mortality of 3.3/100,000, PIH exerts a great burden on medical and social expenditures in China [23].…”