Oxidative stress in the of alcoholic liver disease

Lf, Panchenko; Bv, Davydov; Nn, Terebilina; Baronets, V. Yu.; As, Zhuravleva

doi:10.18097/pbmc20135904452

Cited by 12 publications

(8 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HBV-, HCV- and alcohol- triggered oxidative stress and induce liver damage[45]. It could be of therapeutic value in protecting the liver from injury, inflammation, and carcinogenesis [46–51]. There are several possible agents for preventing stress related liver pathogenesis, such as curcumin [52, 53], silymarin [54], green tea [55], and vitamins C or E [56].…”

Section: Discussionmentioning

confidence: 99%

Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy

2019

View full text Add to dashboard Cite

The poor prognosis of hepatocellular carcinoma (HCC) has been attributed to a high frequency of tumor metastasis and recurrence even after successful surgical resection. With less than 30% of patients benefiting from curative treatment, alternative treatment regimens for patients with advanced HCC are needed. Propyl gallate (PG), a synthetic antioxidant used in preserving food and medicinal preparations, has been shown to induce cancer cell death, but the anticancer effects of PG in HCC are unclear. In the present study, we demonstrated that PG inhibited HCC cell proliferation in vitro and in zebrafish models in vivo in a dose- and time-dependent manner. PG also induced cell apoptosis and increased the number of necrotic cells in a time- and dose-dependent manner as determined using a high-content analysis system. We found that PG also increased the intracellular levels of superoxide and reactive oxidative stress as well as the formation of autophagosomes and lysosomes. Regarding the molecular mechanism, PG did not alter the levels of autophagy-related 5 (ATG5), ATG5/12 or Beclin-1 but increased the rate of the LC3-I to LC3-II conversion, suggesting autophagy induction. PG exposure increased the levels of the pro-apoptotic proteins cleaved caspase-3, cleaved PARP, Bax, and Bad and a decreased level of the anti-apoptotic protein Bcl-2. In conclusion, we demonstrate that PG inhibits HCC cell proliferation through enhanced ROS production and autophagy activation. Finally, PG-treated cells induced cell apoptosis and may be a new candidate for HCC therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy

2019

View full text Add to dashboard Cite

show abstract

“…The infiltration of inflammatory cells, activation of macrophage, and the proinflammatory mediators like LPS, TNF- α , IL1 β , and IL6 induced by various pathways, such as alcohol-regulated CD14/Toll-like receptor 4 (TLR4) pathway, could provoke cellular injury and apoptosis, resulting in ALD [18, 19]. The activation of KCs by lipopolysaccharides (LPS) via TLR4 is critical to the onset of alcohol-induced hepatic damage, which could enhance the production of inflammatory cytokines and ROS which contribute to ALD [31, 49, 50]. MicroRNA-155, an important regulator of inflammation, has been demonstrated to play a vital role in alcohol-induced steatohepatitis and fibrosis.…”

Section: The Relationship and Interdependence Between Oxidative Stmentioning

confidence: 99%

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

Hong

Tan

et al. 2016

Oxidative Medicine and Cellular Longevity

264

179

View full text Add to dashboard Cite

The crucial roles of oxidative stress and inflammation in the development of hepatic diseases have been unraveled and emphasized for decades. From steatosis to fibrosis, cirrhosis and liver cancer, hepatic oxidative stress, and inflammation are sustained and participated in this pathological progressive process. Notably, increasing evidences showed that oxidative stress and inflammation are tightly related, which are regarded as essential partners that present simultaneously and interact with each other in various pathological conditions, creating a vicious cycle to aggravate the hepatic diseases. Clarifying the interaction of oxidative stress and inflammation is of great importance to provide new directions and targets for developing therapeutic intervention. Herein, this review is concerned with the regulation and interdependence of oxidative stress and inflammation in a variety of liver diseases. In addition to classical mediators and signaling, particular emphasis is placed upon immune suppression, a potential linkage of oxidative stress and inflammation, to provide new inspiration for the treatment of liver diseases. Furthermore, since antioxidation and anti-inflammation have been extensively attempted as the strategies for treatment of liver diseases, the application of herbal medicines and their derived compounds that protect liver from injury via regulating oxidative stress and inflammation collectively were reviewed and discussed.

show abstract

“…It has been reported that in alcoholic patients oxidative stress contributes strongly to forming somatic complications [ 64 ], disturbance of immune status [ 65 ], and induction of apoptosis [ 66 ]. In alcoholism, formation of OS can be increased by ethanol, the concentration of which significantly exceeds the norm in patients, as well as the toxic metabolite of ethanol-acetaldehyde, whose level also increases in the organism during alcoholic intoxication.…”

Section: Correction Of Oxidative Stress With Carnosine In Alcoholimentioning

confidence: 99%

Use of Carnosine for Oxidative Stress Reduction in Different Pathologies

Prokopieva

Yarygina

Бохан

et al. 2016

Oxidative Medicine and Cellular Longevity

103

View full text Add to dashboard Cite

The main properties and biological effects of the antioxidant carnosine, the natural dipeptide β-alanyl-L-histidine, are considered. Data on the effective use of carnosine in different pathologies are presented. Special attention is paid to issues of use of carnosine in neurologic and mental diseases, in alcoholism as well as in physiological states accompanied by activation of free-radical processes and formation of oxidative stress.

show abstract

Oxidative stress in the of alcoholic liver disease

Cited by 12 publications

References 12 publications

Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy

Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy

Insights into the Role and Interdependence of Oxidative Stress and Inflammation in Liver Diseases

Use of Carnosine for Oxidative Stress Reduction in Different Pathologies

Contact Info

Product

Resources

About