Use of Carnosine for Oxidative Stress Reduction in Different Pathologies

Prokopieva, V. D.; Yarygina, E.G.; Бохан, Н. А.; Ivanova, Svetlana A.

doi:10.1155/2016/2939087

Cited by 103 publications

(84 citation statements)

References 61 publications

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“…CAR enhances the activities of major antioxidant enzymes and prevents oxidation/glycation of cellular macromolecules, delaying aging . Several studies have found that CAR can prevent/treat pathologies involving oxidative stress . NAC has been used for decades in the treatment of several pathologies.…”

Section: Discussionmentioning

confidence: 99%

Ameliorative effect of carnosine and N‐acetylcysteine against sodium nitrite induced nephrotoxicity in rats

Ansari

Khan

Mahmood

2018

J of Cellular Biochemistry

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The widespread use of sodium nitrite (NaNO2) for various industrial purposes has increased human exposure to alarmingly high levels of nitrate/nitrite. Because NaNO 2 is a strong oxidizing agent, induction of oxidative stress is one of the mechanisms by which it can exert toxicity in humans and animals. We have investigated the possible protection offered by carnosine (CAR) and N‐acetylcysteine (NAC) against NaNO 2‐induced nephrotoxicity in rats. Animals orally received CAR at 100 mg/kg body weight/d for seven days or NAC at 100 mg/kg body weight/d for five days followed by a single oral dose of NaNO 2 at 60 mg/kg body weight. The rats were killed after 24 hours, and the kidneys were removed and processed for various analyses. NaNO 2 induced oxidative stress in kidneys, as shown by the decreased activities of antioxidant defense, brush border membrane, and metabolic enzymes. DNA‐protein crosslinking and DNA fragmentation were also observed. CAR/NAC pretreatment significantly protected the kidney against these biochemical alterations. Histological studies supported these findings, showing kidney damage in NaNO 2‐treated animals and reduced tissue impairment in the combination groups. The protection offered by CAR and NAC against NaNO 2‐induced damage, and their nontoxic nature, makes them potential therapeutic agents against nitrite‐induced nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Ameliorative effect of carnosine and N‐acetylcysteine against sodium nitrite induced nephrotoxicity in rats

Ansari

Khan

Mahmood

2018

J of Cellular Biochemistry

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“…Natural antioxidative peptide in organism, mainly included carnosine and glutathione system. Carnosine is a kind of natural water-soluble dipeptide which has high effective bioactivity, can effectively eliminate oxygen derived free radicals, aldehydes, lipoidase, ROS and so on, with strong antioxidant activity [14] . Carnosine could inhibit intracellular peroxidation but to inhibit membranal peroxidation that it was able to inhibit every oxidation reaction of the whole peroxidation [15] .…”

Section: Discussionmentioning

confidence: 99%

Analysis of Endogenous Antioxidant Peptides and Oxidative Stress Levels in Diabetic Cardiomyopathy

Qi¹,

Chang²,

Wu³

et al. 2018

dtbh

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Abstract. To investigate endogenous carnosine, glutathione system and oxidative stress levels in serum of patients with diabetic cardiomyopathy, and analyze relationships among endogenous carnosine, glutathione system and oxidative stress of patients with diabetic cardiomyopathy. The serum of 68 healthy people (NC), 75 patients with type 2 diabetes mellitus (DM) and 57 patients with diabetic cardiomyopathy (DCM) of the third affiliated hospital of QiQihar Medical University were collected. Carnosine content was measured by ELISA. T-GSH, GSH and GSSG were measured by micro-enzyme labeling. Clinical datas were compared: In comparison to NC group, BMI, FPG, 2hPG,C peptide and HbA1c in the DCM group and DM group increased significantly (P<0.05). The average value of human serum carnosine content, GSH content, GSH/GSSG ratio in the DM and DCM group were significantly lower than that in the control one (P<0.05). Serum endogenous antioxidant peptides and reduced glutathione (GSH) level drop and the imbalance of redox state in diabetic cardiomyopathy patients, which promote the occurrence and development of diabetic cardiomyopathy.

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“…It is easily absorbed in the digestive tract, penetrates the blood-brain barrier, and has high bioavailability and membrane-stabilizing action [169]. Carnosine is a known antioxidant and neuroprotective agent [170,171] and reduces inflammation and neurodegeneration by lowering TNF-α and nitric oxide synthesis [172].…”

Section: Supplementsmentioning

confidence: 99%

Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy

Marchezan

Santos

Deckmann

et al. 2018

Neuroimmunomodulation

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Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with an unknown etiology and currently few effective therapies. Immune system alterations have being demonstrated in ASD, both in humans and via animal models; immune imbalance thus arises as a possible pathway for drug intervention. In this review, the studies were classified into 2 major groups: (1) clinical research whose authors classify therapies with primary anti-inflammatory and immunomodulatory actions, making use of: sulforaphane, celecoxib, lenalidomide, pentoxifylline, spironolactone, flavonoid luteolin, corticosteroids, oral immunoglobulin, intravenous immunoglobulin, cell therapy, dialyzable lymphocyte extracts, minocycline, and pioglitazone; and (2) other ASD therapies already used or currently under study whose initial characteristics were neither anti-inflammatory nor immunomodulatory initially, but displayed a capacity for immunomodulation throughout the treatment: risperidone, vitamin D, omega-3, Ginkgo biloba, L-carnosine, N-acetylcysteine, and microbiome restoration. These studies used various data acquisition methodologies. Questions arose such the need for randomized and placebo-controlled studies with greater numbers of participants as well as the use of biomarkers to refine the treatment of autistic subjects.

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Use of Carnosine for Oxidative Stress Reduction in Different Pathologies

Cited by 103 publications

References 61 publications

Ameliorative effect of carnosine and N‐acetylcysteine against sodium nitrite induced nephrotoxicity in rats

Ameliorative effect of carnosine and N‐acetylcysteine against sodium nitrite induced nephrotoxicity in rats

Analysis of Endogenous Antioxidant Peptides and Oxidative Stress Levels in Diabetic Cardiomyopathy

Immunological Dysfunction in Autism Spectrum Disorder: A Potential Target for Therapy

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