Oxidative stress in patients with COPD and pulmonary hypertension

Abstract

The study demonstrates the presence of oxidative/antioxidative imbalance in the systemic circulation in patients with COPD: compared with healthy subjects, COPD patients had higher serum MDA concentrations and lower GPX activity in erythrocytes. The magnitudes of the increase in MDA and reduction in GPX activity were similar in COPD patients with pulmonary hypertension and in those with normal pulmonary artery pressures.

Chronic Obstructive Pulmonary Disease and Paraoxonase-1 192 and 55 Gene Polymorphisms

“…interestingly, Joppa et al in their study described the potential relationship between pulmonary hypertension and markers of systemic oxidative stress in well defined patients with coPD (12). We also found relationship between Pon1 192 gene polymorphisms and low serum Pon1 levels in coPD patients in comparison to healthy non-smokers and smokers withouth coPD.…”

Altered antioxidant enzyme activity with severity and comorbidities of chronic obstructive pulmonary disease (COPD) in South Indian population

“…Whereas, erythrocyte GPx activity and TAS showed a significant decrease in the mean value of COPD patients with type 2 diabetes. Joppa et al also reported a significant decrease in the GPx activity in erythrocyte of COPD patients with and without pulmonary hypertension [55]. Some of the previous finding of Orhan et al showed a significant increase in plasma GPx activity in hypertensive preeclamptic pregnancy and also in insulin dependent diabetic pregnancy [56].…”

Heart rate-corrected QT interval and QT dispersion in patients with pulmonary hypertension

“…PH is the main cause of right ventricular hypertrophy. The pathogenesis of PH is not fully understood: it can be idiopathic and also can share the same pathophysiology and be complicated with other diseases such as chronic obstructive pulmonary disease [10]. The quality of life in patients with PH can be very poor.…”