Heart rate-corrected QT interval and QT dispersion in patients with pulmonary hypertension

Zhang, Hongliang; Luo, Qin; Liu, Zhihong; Zhao, Zhihui; Xiong, Changming; Ni, Xin‐Hai; He, Jieyu; Wei, Yingjie; Zhang, Shu

doi:10.1007/s00508-009-1184-9

Cited by 43 publications

(42 citation statements)

References 21 publications

(25 reference statements)

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“…The mPAP of our patients was lower than in the comparable group in Hong-Liang's study (patients with mild-to-moderate PH) and lower than in Rich's study. Rich's sample clearly had higher pulmonary vascular resistance than our sample, and Hong-Liang did not provide these data [23,24]. The shorter QTc interval in our patients may have been due to lower dilatation of the right ventricle.…”

Section: Discussioncontrasting

confidence: 51%

“…The QTc interval was longer in patients with PH than in controls (Hong-Liang's study, severe PH: 428.6 ± 32.8 ms, mild to moderate PH: 423.1 ± 30.2 ms; controls: 411.1 ± 28.4 ms; criteria for mild to moderate PH: mPAP ≥ 25 mm Hg and < 60 mm Hg, criteria for severe PH: mPAP ≥ 60 mm Hg) [23]. In Rich's et al study [24], the QTc interval was 454.8 ± 29 ms in patients with PH compared with 429 ± 18 ms in controls.…”

Section: Discussionmentioning

confidence: 96%

“…There have been two studies comparing duration of the QTc-interval in controls and patients with different types of PH [23,24]. The QTc interval was longer in patients with PH than in controls (Hong-Liang's study, severe PH: 428.6 ± 32.8 ms, mild to moderate PH: 423.1 ± 30.2 ms; controls: 411.1 ± 28.4 ms; criteria for mild to moderate PH: mPAP ≥ 25 mm Hg and < 60 mm Hg, criteria for severe PH: mPAP ≥ 60 mm Hg) [23].…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the prognostic value of electrocardiography parameters and heart rhythm in patients with pulmonary hypertension

et al. 2016

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Background: Several studies have analyzed arrhythmias in patients with pulmonary hypertension (PH) and increased P-wave duration was identified as a risk factor for development of atrial fibrillation (AF 79.4 ± 5.4 months (sinus rhythm), (p = 0.565). Conclusions: Atrial fibrillation predict adverse prognosis in patients with PH and a longer P-wave (> 0.11 s) is associated with shorter survival time. (Cardiol J 2016; 23, 4: 465-472)

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Section: Discussioncontrasting

confidence: 51%

Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

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Evaluation of the prognostic value of electrocardiography parameters and heart rhythm in patients with pulmonary hypertension

et al. 2016

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“…Electrophysiological mechanisms by which atrial stretch leads to supraventricular arrhythmias are not fully understood, but studies suggest that volume and pressure overload in the heart can activate stretchactivated ion channels inducing atrial premature beats (NAZIR & LAB, 1996;KAMKIN et al, 1999). Another risk factor for the arrhythmogenic substrate in the dog of the present report is the presence of pulmonary hypertension, which can modulate autonomic activity and delay cardiac repolarization (HONG-LIANG et al, 2009;RAJDEV et al, 2012).…”

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confidence: 70%

Trigeminismo supraventricular em um cão com doença mixomatosa da valva mitral

Soares¹

2017

Cienc. Rural

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RESUMO: O trigeminismo supraventricular é um distúrbio incomum de formação do impulso elétrico cardíaco. Detectar e tratar arritmias cardíacas são um importante objetivo terapêutico em cardiologia. O objetivo desta nota é relatar a ocorrência de trigeminismo supraventricular em um cão com doença mixomatosa da valva mitral (DMVM). Um cão sem raça definida, macho, inteiro, 15 anos de idade e 13kg foi levado para avaliação cardíaca com um histórico de sopro cardíaco, tosse, dispneia e ascite. Os achados ecocardiográficos foram compatíveis com doença mixomatosa de valvas mitral e tricúspide com comprometimento hemodinâmico severo. A eletrocardiografia (ECG) revelou arritmia sinusal com presença de complexos supraventriculares prematuros isolados, aos pares e períodos de trigeminismo supraventricular. O trigeminismo supraventricular não é relatado em estudos retrospectivos e prospectivos que avaliaram arritmias cardíacas em um grande número de cães. O presente relato evidencia que o trigeminismo supraventricular pode ocorrer em cães com DMVM e comprometimento hemodinâmico severo, provavelmente relacionado à dilatação atrial. Ainda, reforça a importância da realização do ECG em cães com DMVM, complementando as informações ecocardiográficas e possibilitando uma melhor abordagem terapêutica.

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“…Arrhythmogenic substrate in rat hearts with monocrotaline-induced pulmonary hypertension may cause steeper RV electrical restitution and rate-dependent RV-LV action potential duration-dispersion, 4 inducing ventricular tachycardia and fibrillation. A study of 201 pulmonary hypertension patients 5 demonstrated that mean heart-rate corrected QT interval (QTc) and QTc dispersion (QTcd) were significantly increased in severely ill patients, compared to patients with mild to moderate pulmonary hypertension. In addition, in women these indices were positively correlated to mean pulmonary arterial pressure, identifying a possible substrate for ventricular arrhythmias.…”

Section: Plausible Causes Of Arrhythmiamentioning

confidence: 99%

Complications Leading to Sudden Cardiac Death in Pulmonary Arterial Hypertension

Demerouti

Manginas²,

Athanassopoulos

et al. 2012

Respir Care

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SummaryPulmonary arterial hypertension (PAH) is a disease of small pulmonary arteries, characterized by vascular proliferation and remodeling. Progressive increase in pulmonary vascular resistance ultimately leads to right ventricular heart failure and death. PAH-specific drug therapy has improved clinical outcomes and survival. While the survival is better, progression of pulmonary vasculopathy contributes to pulmonary artery dilatation. Left main compression syndrome, pulmonary artery dissection, pulmonary artery rupture, and severe hemoptysis are reported as complications leading to sudden cardiac death, an event encountered more often in PAH patients. The advent of PAHtargeted drug therapy has reduced referral for lung transplantation; however, severe complications require rapid diagnosis, decision making, and possible registration on a lung transplantation waiting list. PAH referral centers provide multidisciplinary emergency care and specific therapeutic management, contributing to improved quality of life and survival for PAH patients. We review the complications leading to sudden death in PAH. Key words: pulmonary hypertension; pulmonary artery dissection; pulmonary artery rupture; left main compression syndrome. [Respir Care 2013;58(7):1246 -1254.

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Heart rate-corrected QT interval and QT dispersion in patients with pulmonary hypertension

Abstract: In women with pulmonary hypertension, mean QTc and QTcd are positively correlated to mean pulmonary arterial pressure and are significantly increased in patients with severe pulmonary hypertension.

Cited by 43 publications

References 21 publications

Evaluation of the prognostic value of electrocardiography parameters and heart rhythm in patients with pulmonary hypertension

Evaluation of the prognostic value of electrocardiography parameters and heart rhythm in patients with pulmonary hypertension

Trigeminismo supraventricular em um cão com doença mixomatosa da valva mitral

Complications Leading to Sudden Cardiac Death in Pulmonary Arterial Hypertension

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