Chronic Obstructive Pulmonary Disease and Paraoxonase-1 192 and 55 Gene Polymorphisms

Tekes, Selahaddin; Işık, Bırgül; Yıldız, Tekin; Şimşek, Selda; Işik, Mehmet; Budak, Turgay

doi:10.2478/v10133-010-0019-1

Cited by 11 publications

(13 citation statements)

References 16 publications

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“…In 2010, in consistent with our results Tekes et al found a significant difference between the PON1 192 RR allele frequency in patients with COPD and control group 38 .…”

Section: Discussionsupporting

confidence: 94%

Assessing the relationship of paraoxonase-1 Q192R polymorphisms and the severity of lung disease in SM-exposed patients

Golmanesh¹,

Bahrami

Pourali

et al. 2013

Immunopharmacology and Immunotoxicology

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Late respiratory complications in patients suffering from pulmonary lesions due to sulfur mustard (SM) gas are asthma, chronic obstructive pulmonary disease and bronchiectasis. Recently PON1 antioxidant activity draws attention as the enzyme which prevents the oxidation of lipoproteins during oxidative stress. In this study we aimed to investigate PON1 192 polymorphisms and paraoxonase and arylesterase activity in the serum of SM-exposed lung disease patients. Also, we examined the detection of PON1 and apoA1 proteins in BAL fluid. 101 male patients were included who were categorized to three groups of mild, moderate and severe suffering from pulmonary lesions due to SM. Significant reduction in paraoxonase activity [Healthy: 412.46 ± 89.1 U/L, Severe: 89.66 ± 20.7 U/L] (p < 0.0001) and arylesterase activity [Healthy: 25826.4 ± 4425.23 U/L, Severe: 16760.43 ± 3814.9 U/L] (p < 0.0001) with increase in severity of disease was demonstrated statistically. With respect to the distribution of the PON1 polymorphism, the RR genotype was more frequent in severe patients [37.2%] than healthy group [10%] (p < 0.05) and no significant regression was found between genotype and PON1 activity. On the other hand, the results of PON1 and apoA1 detection illustrated that only apoA1 protein was found in BAL fluid. According to our findings it seems that increase in the stress oxidative in chemical injured veterans with pulmonary complications comes with reduction in PON1 enzyme activity and appearance of RR genotype rises up with the increase in disease severity. Since a significant correlation between enzyme activity and genotype was not observed altering these two variables with each other requires more studies.

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“…In 2010, in consistent with our results Tekes et al found a significant difference between the PON1 192 RR allele frequency in patients with COPD and control group 38 .…”

Section: Discussionsupporting

confidence: 94%

Assessing the relationship of paraoxonase-1 Q192R polymorphisms and the severity of lung disease in SM-exposed patients

Golmanesh¹,

Bahrami

Pourali

et al. 2013

Immunopharmacology and Immunotoxicology

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“…Tekes et al [2] found that PON-1 Q192R gene polymorphism can cause a decrease in serum PON1 activity and contribute to COPD development. Another study showed that Q192R and -108>Ct polymorphisms could be associated with serum PON1 and aril esterase levels in patients with COPD in a Croatian population.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that enzyme activity is altered as a result of these polymorphisms. [2,5,6] In the present study, we aimed to investigate the association of COPD, in which oxidative stress is involved in pathogenesis, and PON1, which has antioxidant properties, with Q192R and L55M polymorphisms.…”

Section: Introductionmentioning

confidence: 99%

“…[1] Paraoxanase-1 (PON1) is a lipophylic antioxidant which is found in the liver and serum as bounded to highdensity lipoprotein (HDL), and PON1 activity may play a protective role against oxidative stress in the lung. [2] The antioxidant role of PON1 is due to its protective effect on low-density lipoproteins against oxidation. The serum PON1 is found in plasma together with HDL and involved in the prevention of plasma lipoprotein oxidation.…”

Section: Introductionmentioning

confidence: 99%

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Paraoxonase-1 gene in patients with chronic obstructive pulmonary disease investigation Q192R and L55M polymorphisms

Gürbüz¹,

Yıldız²,

Kara³

et al. 2015

World Journal of Emergency Medicine

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BACKGROUND:The effect of increased oxidative stress on the development of chronic obstructive pulmonary disease (COPD) is well known. One of the antioxidative systems against oxidative stress in human body is paraoxonase (PON) enzyme that protects low density lipoproteins (LDL) against oxidation. This study aimed to explore the polymorphisms on PON1, Q192R, L55M genes of patients with COPD.METHODS: DNAs extraction was obtained from blood samples of 50 patients diagnosed with COPD and 50 patients as a control group who were presented to emergency clinic. Genotypes were obtained with polymerase chain reaction (PCR) and AIw I and Hsp92II restriction enzymes were used for Q192R and L55M polymorphisms, respectively. Analysis of data was done with the Chi-square test and Fisher's exact test. RESULTS:A statistically significant difference in Q192R polymorphism was found between the COPD patients and the control group (P=0.05). There was no statistically signifi cant difference in L55M polymorphisms between the patient and control groups (P>0.05). Q192R polymorphism was signifi cantly correlated with the PON1 gene and cigarette smoking; however other risk factors did not show any significant correlation with this polymorphism. Though L55M polymorphism was signifi cantly correlated with family history and tuberculosis, there was no signifi cant correlation with other risk factors. CONCLUSION:We believe that more studies are needed to study the correlation of L55M polymorphism with other factors.

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“…Smoking may enhance oxidative stress directly through the release of reactive oxygen and nitrogen radicals, and indirectly by weakening the antioxidant defence systems. Paraoxonase 1 (PON1) is an enzyme localized in Clara cells, endothelial cells, and type 1 cells of the alveolar epithelium with supposed protective role against oxidative stress (3,(5)(6)(7).…”

Section: Introductionmentioning

confidence: 99%

Paraoxonase 1 Activity in Patients with Chronic Obstructive Pulmonary Disease

Rumora

Rajković

Kopcinovic³

et al. 2014

COPD: Journal of Chronic Obstructive Pulmonary Disease

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Reduction of PON1 activity observed in COPD patients could be partly caused by oxidative environment. Lower concentrations of reduced thiol groups in COPD patients suggest that a decrease in PON1 activity could reflect oxidative changes of enzyme free cysteine residues. Furthermore, decreased PON1 arylesterase activity might indicate a down-regulation of PON1 concentration. Our results suggest that ARE could be considered as potential biomarker for COPD diagnosis.

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Chronic Obstructive Pulmonary Disease and Paraoxonase-1 192 and 55 Gene Polymorphisms

Cited by 11 publications

References 16 publications

Assessing the relationship of paraoxonase-1 Q192R polymorphisms and the severity of lung disease in SM-exposed patients

Assessing the relationship of paraoxonase-1 Q192R polymorphisms and the severity of lung disease in SM-exposed patients

Paraoxonase-1 gene in patients with chronic obstructive pulmonary disease investigation Q192R and L55M polymorphisms

Paraoxonase 1 Activity in Patients with Chronic Obstructive Pulmonary Disease

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