Oxidative stress, DNA damage, and mutagenicity induced by the extractable organic matter of airborne particulates on bacterial models

Velali, Ekaterini; Pantazaki, Αnastasia A.; Besis, Athanasios; Choli‐Papadopoulou, Theodora; Samara, Constantini

doi:10.1016/j.yrtph.2019.03.004

Cited by 20 publications

(10 citation statements)

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“…quinones and hydroxy-quinones (Verma et al, 2015). It has been shown in controlled experiments that the chemical ageing of PM from various origins would increase its ROS activity, and this effect is enhanced in the presence of O 3 (Li et al, 2009;McWhinney et al, 2011;Stevanovic et al, 2013;Verma et al, 2015;Antiñolo et al, 2015). This process has been attributed to the oxidation of PAHs and formation of water-soluble derivatives.…”

Section: Introductionmentioning

confidence: 99%

“…In the aerosol aqueous phase, HULIS can increase the solubility of hydrophobic organic compounds and change the reactivity and solubility of metal aerosols, owing to metal-complexation properties (Graber and Rudich, 2006). Finally, due to the presence of redox-active moieties, HULIS can catalyse electron transfer reactions and formation of reactive oxygen species (ROS), which could pose oxidative stress in humans upon inhalation (Verma et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Composition and mass size distribution of nitrated and oxygenated aromatic compounds in ambient particulate matter from southern and central Europe – implications for the origin

et al. 2020

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Abstract. Nitro-monoaromatic hydrocarbons (NMAHs), such as nitrocatechols, nitrophenols and nitrosalicylic acids, are important constituents of atmospheric particulate matter (PM) water-soluble organic carbon (WSOC) and humic-like substances (HULIS). Nitrated and oxygenated derivatives of polycyclic aromatic hydrocarbons (NPAHs and OPAHs) are toxic and ubiquitous in the ambient air; due to their light absorption properties, together with NMAHs, they are part of aerosol brown carbon (BrC). We investigated the winter concentrations of these substance classes in size-resolved PM from two urban sites in central and southern Europe, i.e. Mainz (MZ), Germany, and Thessaloniki (TK), Greece. The total concentration of 11 NMAHs (∑11NMAH concentrations) measured in PM10 and total PM were 0.51–8.38 and 12.1–72.1 ng m−3 at the MZ and TK sites, respectively, whereas ∑7OPAHs were 47–1636 and 858–4306 pg m−3, and ∑8NPAHs were ≤90 and 76–578 pg m−3, respectively. NMAHs contributed 0.4 % and 1.8 % to the HULIS mass at MZ and TK, respectively. The mass size distributions of the individual substances generally peaked in the smallest or second smallest size fraction i.e. <0.49 or 0.49–0.95 µm. The mass median diameter (MMD) of NMAHs was 0.10 and 0.27 µm at MZ and TK, respectively, while the MMDs of NPAHs and OPAHs were both 0.06 µm at MZ and 0.12 and 0.10 µm at TK. Correlation analysis between NMAHs, NPAHs, and OPAHs from one side and WSOC, HULIS, sulfate, and potassium from the other suggested that fresh biomass burning (BB) and fossil fuel combustion emissions dominated at the TK site, while aged air masses were predominant at the MZ site.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Composition and mass size distribution of nitrated and oxygenated aromatic compounds in ambient particulate matter from southern and central Europe – implications for the origin

et al. 2020

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“…Therefore, the aim of this study was to discover synthetic compounds based on 5-hydroxymethylfurfural (5-HMF) isolated from S. chinensis f. pilosa Ohwi extract for the treatment of neuropathic pain. Because 5-HMF has a possible toxic mechanism [18], we used a Salmonella typhimurium mutagenicity based test (Ames test), which is a suitable bacterial assay to detect mutagenic potential [19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Extract and Synthesized Derivatives of Isolated Compound from Symplocos chinensis f. Pilosa Ohwi on Neuropathic Pain in Mice

et al. 2021

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Neuropathic pain is described as the “most terrible of all tortures that a nerve wound may inflict.” The aim of the present study was to demonstrate the antinociceptive effect of Symplocos chinensis f. pilosa Ohwi water extract (SCW) and synthesized derivatives of the isolated compound. The antinociceptive effect was tested using the acetic acid-induced writhing and 5% formalin tests. Antinociceptive effects on neuropathic pain were evaluated using the von Frey test with chronic constriction injury (CCI) and surgical nerve injury (SNI) models and tail-flick test with a vincristine-induced pain model. An Ames test was also conducted. 5-hydroxymethylfurfural (5-HMF) was isolated and derivatives were synthesized with various acid groups. Among the plant water extracts, SCW showed significantly effective activity. Additionally, SCW presented antinociceptive effects in the neuropathic pain models. The SCW water fraction resulted in fewer writhes than the other fractions, and isolated 5-HMF was identified as an effective compound. Because 5-HMF revealed a positive response in the Ames test, derivatives were synthesized. Among the synthesized derivations, 5-succinoxymethylfurfural (5-SMF) showed the best effect in the neuropathic pain model. Our data suggest that SCW and the synthesized compound, 5-SMF, possess effective antinociceptive activity against neuropathic pain.

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“…Organic chemicals in ambient PM contribute significantly to air pollution and its adverse health effects (Lewtas 1993;Jones 1999;Shiraiwa et al 2017). Extracts of ambient wood burning aerosol induce mutagenicity and intracellular production of ROS more than road traffic aerosol (Velali et al 2019). Polar fractions of organic PM extracts show higher toxicities than apolar ones (Nováková et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Nitrated monoaromatic hydrocarbons (nitrophenols, nitrocatechols, nitrosalicylic acids) in ambient air: levels, mass size distributions and inhalation bioaccessibility

Kitanovski

Hovorka

Kuta

et al. 2020

Environ Sci Pollut Res

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Nitrated monoaromatic hydrocarbons (NMAHs) are ubiquitous in the environment and an important part of atmospheric humic-like substances (HULIS) and brown carbon. They are ecotoxic and with underresearched toxic potential for humans. NMAHs were determined in size-segregated ambient particulate matter collected at two urban sites in central Europe, Ostrava and Kladno, Czech Republic. The average sums of 12 NMAHs (Σ12NMAH) measured in winter PM10 samples from Ostrava and Kladno were 102 and 93 ng m−3, respectively, and 8.8 ng m−3 in summer PM10 samples from Ostrava. The concentrations in winter corresponded to 6.3–7.3% and 2.6–3.1% of HULIS-C and water-soluble organic carbon (WSOC), respectively. Nitrocatechols represented 67–93%, 61–73% and 28–96% of NMAHs in PM10 samples collected in winter and summer at Ostrava and in winter at Kladno, respectively. The mass size distribution of the targeted substance classes peaked in the submicrometre size fractions (PM1), often in the PM0.5 size fraction especially in summer. The bioaccessible fraction of NMAHs was determined by leaching PM3 samples in two simulated lung fluids, Gamble’s solution and artificial lysosomal fluid (ALF). More than half of NMAH mass is found bioaccessible, almost complete for nitrosalicylic acids. The bioaccessible fraction was generally higher when using ALF (mimics the chemical environment created by macrophage activity, pH 4.5) than Gamble’s solution (pH 7.4). Bioaccessibility may be negligible for lipophilic substances (i.e. log KOW > 4.5).

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Oxidative stress, DNA damage, and mutagenicity induced by the extractable organic matter of airborne particulates on bacterial models

Cited by 20 publications

References 65 publications

Composition and mass size distribution of nitrated and oxygenated aromatic compounds in ambient particulate matter from southern and central Europe – implications for the origin

Composition and mass size distribution of nitrated and oxygenated aromatic compounds in ambient particulate matter from southern and central Europe – implications for the origin

Effect of Extract and Synthesized Derivatives of Isolated Compound from Symplocos chinensis f. Pilosa Ohwi on Neuropathic Pain in Mice

Nitrated monoaromatic hydrocarbons (nitrophenols, nitrocatechols, nitrosalicylic acids) in ambient air: levels, mass size distributions and inhalation bioaccessibility

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