Oxidative stress development in the tissues of salivary glands of rats in conditions of monosodium glutamate-induced obesity

Hordiienko, L. P.; Berehova, T. V.; Neporada, KS; Falalieieva, TM

doi:10.15407/fz60.04.105

Cited by 7 publications

(9 citation statements)

References 3 publications

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“…In models of obesity induced in animals by monosodium glutamate (MSG), a significant increase in the content of substances reactive to thiobarbituric acid and a significant reduction in the activity of superoxide dismutase and catalase have been observed, which suggest an imbalance in the pro-oxidant and antioxidant systems and the onset of oxidative stress, 16 , 33 , which may indicate an imbalance in the pro-oxidant and antioxidant systems and the onset of oxidative stress. Alterations observed in other organs such as kidney and liver 34 .…”

Section: Obesity and Salivary Glandsmentioning

confidence: 99%

Obesity, salivary glands and oral pathology

Roa

Sol

2018

Colomb Med

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Obesity has reached pandemic proportions in recent years. Not only adults suffer from the disease, but increasingly children and young people. One of the main causes of overweight and obesity is excessive food intake, in particular heavily processed carbohydrates. Obesity alters multiple organs, including the salivary glands, bringing functional alterations with it. Among researchers, the relation between obesity and tooth decay, periodontal disease and xerostomia is being debated. More and more scientific reports are drawing attention to the changes in the microflora of the oral cavity during obesity. All changes are closely related to the morphological and functional alterations of the salivary glands. This article review presents the current points of view regarding the impact of obesity on the health of the salivary glands, and how changes their functions influence other structures in the oral cavity.

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Section: Obesity and Salivary Glandsmentioning

confidence: 99%

Obesity, salivary glands and oral pathology

Roa

Sol

2018

Colomb Med

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“…In addition to the obesogenic action of MSG, a possible relation that it has in collagen synthesis has also been reported (Tapiero et al, 2002). On the other hand, MSG has been related to morphofunctional changes in several organs (Henry-Unaeze, 2017), including the salivary glands (Hordiienko et al, 2014). Our aim was to evaluate the influence of exposure time to MSG-induced obesity on the changes in the amount of types I and III collagen in the parotid gland of Sprague Dawley rats.…”

Section: Introductionmentioning

confidence: 91%

Types I and III Parotid Collagen Variations and Serum Biochemical Parameters in Obese Rats Exposed to Monosodium Glutamate

Roa

Sol

2020

Int. J. Morphol.

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“…The literature reports on the toxic effects of MSG are scarce and mostly address the issues of glutamate-induced obesity [6,7] and neurotoxicity [8][9][10]. Moreover, it should be pointed out that the majority of toxicity studies have been performed with large doses of sodium glutamate.…”

Section: Background and Aimsmentioning

confidence: 99%

Gender-Specific Differences of Oxidative Processes in the Population of Circulating Neutrophils of Rats in a Setting of Prolonged Administration of Monosodium Glutamate

Krynytska

Rutska

2019

Romanian Journal of Diabetes Nutrition and Metabolic Diseases

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Background and aims:Monosodium salt of glutamic acid (MSG) is one of the most common food additives. The aim of study was to assess, in gender-specific terms, how prolonged administration of MSG effects on reactive oxygen and nitrogen species formation and the apoptotic/necrotic processes in the population of rats circulating neutrophils. Material and methods: Experimental studies were conducted on 32 mature white rats. MSG was administered intragastrical at a dose of 30 mg/kg body weight for 30 days. The analysis of cell samples to determine neutrophils with overproduction of reactive oxygen species (ROS) and signs of apoptosis\necrosis was evaluated with flow laser cytometry method. The total nitric oxide synthase (NOS) activity was determined by monitoring the rate of conversion of L-arginine into citrulline. The total quantity of NO metabolites was assessed by evaluating of nitrite and nitrate ions. Results: We found a significant increase in generation of ROS, intensification of nitroxydergic processes, an increase in the percentage of apoptotic neutrophils and no changes in the percentage of necrotic neutrophils. Conclusions: We observed activation of oxidative and nitroxydergic processes in rats with prolonged administration of MSG, which initiate apoptosis. In gender-specific terms, a more pronounced changes were seen in male rats. key words: monosodium glutamate, reactive oxygen species, nitric oxide, NO-synthase; apoptosis.

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Oxidative stress development in the tissues of salivary glands of rats in conditions of monosodium glutamate-induced obesity

Cited by 7 publications

References 3 publications

Obesity, salivary glands and oral pathology

Obesity, salivary glands and oral pathology

Types I and III Parotid Collagen Variations and Serum Biochemical Parameters in Obese Rats Exposed to Monosodium Glutamate

Gender-Specific Differences of Oxidative Processes in the Population of Circulating Neutrophils of Rats in a Setting of Prolonged Administration of Monosodium Glutamate

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