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Âïëèâ ìóëüòèïðîá³îòèêà ñèìá³òåðó àöèäîô³ëüíîãî íà ïàòîëîã³÷í³ çì³íè ó ê³ñòêîâ³é òêàíèí³ ïàðîäîíòà ïðè ã³ïîàöèäíîñò³ Íà ìîäåë³ îìåïðàçîë³íäóêîâàíîãî ã³ïîàöèäèòåòó îáãðóíòîâàíî åêñïåðèìåíòàëüíó êîðåêö³þ ïàòîëîã³÷íèõ çì³í ó ê³ñòêîâ³é òêàíèí³ ïàðîäîíòà ìóëüòèïðîá³îòèêîì ñèìá³òåðîì. Äîâåäåíî, ùî éîãî âèêîðèñòàííÿ â óìîâàõ òðèâàëî¿ ã³ïîàöèäíîñò³ øëóíêîâîãî ñîêó ñïðèÿº ïîïåðåäaeåííþ êàòàáîë³çìó êîëàãåíîâèõ ³ íåêîëàãåíîâèõ á³ëê³â îðãàí³÷íîãî ìàòðèêñó ê³ñòîê íèaeí³õ ùåëåï ³ íîðìàë³çàö³¿ NO-åðã³÷íî¿ ñèñòåìè.

Under conditions of omeprazole-induced hypergastrinemia the activity of NOS and the concentration of NO 2 , the end product of metabolism of nitric oxide were studied in salivary glands of rats. We detected an increase in NOS activity, reaching a maximum (7,61±0,39 ìmol [NO 2 ]/(g*min) at 14th day of the experiment. At 28th day following omeprazole introduction its activity was 5,76±0,25 ìmol [NO 2 ]/(g*min).