2020
DOI: 10.3390/antiox9030196
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Oxidative Stress and Atopic Dermatitis

Abstract: Atopic dermatitis is a common chronic/chronically relapsing inflammatory skin disease, with increasing worldwide prevalence. Etiopathogenesis is complex and multifactorial, with a mix of genetic, immunological and environmental aspects. Like in other chronic inflammatory diseases, oxidative stress plays an important pathogenetic role. We reviewed in vivo research studies on humans about oxidative stress and atopic dermatitis. Although sometimes contrasting, overall, they suggest that oxidative stress may have … Show more

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Cited by 92 publications
(72 citation statements)
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“…Previous studies reported the involvement of ROS and lipid peroxidation in the pathogenesis of inflammatory skin diseases [ 19 , 36 , 37 , 38 , 39 ]. The relationship between oxidative stress and AD was recently revised [ 3 , 4 , 5 ]. Higher levels of MDA, a biomarker of lipid peroxidation, were demonstrated [ 10 ].…”
Section: Discussionmentioning
confidence: 99%
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“…Previous studies reported the involvement of ROS and lipid peroxidation in the pathogenesis of inflammatory skin diseases [ 19 , 36 , 37 , 38 , 39 ]. The relationship between oxidative stress and AD was recently revised [ 3 , 4 , 5 ]. Higher levels of MDA, a biomarker of lipid peroxidation, were demonstrated [ 10 ].…”
Section: Discussionmentioning
confidence: 99%
“…Although the pathogenesis of AD is not completely understood, genetic, environmental, and/or psychological triggers appear to be involved in and contribute to the infiltration of inflammatory cells, such as lymphocytes, macrophages, eosinophils, and mast cells [ 2 ]. The chronically inflamed skin of patients with atopic dermatitis plays a key role in the pathogenesis of this disease, with the overproduction of reactive oxygen species (ROS) [ 3 , 4 , 5 , 6 ]. The overproduction of ROS was observed in skin biopsies in AD patients compared to controls [ 6 ].…”
Section: Introductionmentioning
confidence: 99%
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“…Haplopine inhibited the expressions of IL-4, IL-13, and COX-2, which were increased by oxidative stress in H 2 O 2 -treated Jurkat T cells. Dysregulation of antioxidant mechanisms contributes to oxidative stress, which is caused by an imbalance between ROS generation and activity of the antioxidant defense system [38][39][40], and reportedly, excessive oxidative stress is a major etiological factor of AD because it induces inflammatory genes such as IL-4, IL-13, and COX-2 [41][42][43][44]. Therefore, inhibition of oxidative stress may importantly alleviate AD by downregulating inflammatory mediator levels.…”
Section: Discussionmentioning
confidence: 99%
“…As of now, we know that RAGE plays a role in a plethora of other physiological and pathological processes, including diabetes, osteoporosis and cardiovascular diseases. Over the course of time, many different factors, including oxidative stress, were studied to explain the pathophysiology of many skin diseases characterized by chronic inflammation and frequent relapses, such as atopic dermatitis [ 21 , 22 , 23 ], psoriasis [ 24 , 25 ], lichen planus [ 26 , 27 ], vitiligo [ 28 , 29 ], or discoid lupus erythematosus [ 30 ]. It is well known that the clinical expression of such diseases depends on a variety of factors, both inner and outer, but, as of yet, one of these factors, namely RAGE, seems to play an important role in a context of continuous inflammatory and autoimmune stimuli, thus prompting further studies in order to complete the picture we have of such diseases.…”
Section: Introductionmentioning
confidence: 99%