Oxidative stress and aging: correlation with clinical parameters

Cruz, Ana Carla da; Petronilho, Fabrícia; Heluany, Claudia Cipriano Vidal; Vuolo, Francieli; Miguel, Samantha Pereira; Quevedo, João; Romano-Silva, Marco Aurélio; Dal‐Pizzol, Felipe

doi:10.1007/s40520-013-0176-9

Cited by 14 publications

(9 citation statements)

References 22 publications

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“…Oxidative stress levels may have been affected by age in the DVT groups. TAS levels may also increase with age, however [28]. Both TOS and TAS levels were correlated with age in the control group in this study, presumably to counterbalance the increased oxidative stress.…”

Section: Discussionsupporting

confidence: 42%

Evaluation of oxidative stress balance in acute deep vein thrombosis

et al. 2015

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Objective: The purpose of this study was to show the association between oxidative stress and deep venous thrombosis (DVT) by determining total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI) values in patients with DVT and to take precautionary measures to balance oxidative status. Methods: TOS, TAS and OSI levels in serum from 52 individuals with DVT and 45 without DVT were compared. Results: TOS and OSI levels were significantly higher in patients with DVT compared with the control group (p<0.0001), but no difference was observed in TAS levels (p=0.118). The patient group was divided into two subgroups, idiopathic and secondary DVT. TOS and OSI levels were significantly higher patients with both idiopathic DVT and secondary DVT compared to the control group (p<0.0001). TAS levels were significantly higher in patients with idiopathic DVT than in the control group, but no difference was observed in the patients with secondary DVT. Conclusion: Specificity and sensitivity values obtained from the receiver operating characteristic (ROC) curve show that TOS and OSI are both markers that can be used in the diagnosis of DVT. Also, determination of oxidative stress markers may guide clinicians to take necessary precautions to balance oxidative stress in the patients. Key Words: Deep vein thrombosis, oxidative stress, total oxidant status, total antioxidant status Conflict of Interest: The authors have no conflict of interest. ÖZETAmaç: Bu çalışmanın amacı akut derin ven trombozlu (DVT) hastalarda toplam oksidan durum (TOS), toplam antioksidan durum (TAS) ve oksidatif stres indeksi (OSI) düzeylerini ölçerek oksidatif stres ve DVT arasındaki ilişkiyi ortaya koymak ve klinisyenlerin bu hastalarda oksidatif stresi dengelemek üzere koruyucu önlemler almasına yardımcı olmaktır. Metod: Bu çalışmada 52 DVT'li ve 45 DVT olmayan bireylerden alınan serum örneklerinde TOS, TAS ve OSI seviyeleri belirlenerek karşılaştırıldı. Bulgular: TOS ve OSI seviyeleri DVT hastalarında kontrol grubu ile karşılaştırıldığında istatistiksel olarak anlamlı yüksek bulunurken (p<0.0001) TAS seviyelerinde fark görülmedi, p=0.118. Hasta grubu idiopatik ve sekonder DVT olarak iki gruba ayrıldı. TOS ve OSI seviyeleri hem idiyopatik DVT hem de sekonder DVT hastalarında kontrol grubu ile karşılaştırıldı-ğında istatistiksel olarak anlamlı yüksek bulundu (p<0.0001). İdiyopatik DVT hastalarında TAS seviyeleri kontrol grubundan anlamlı yüksek iken sekonder DVT hastalarında fark gözlenmedi. Sonuç: Sonuç olarak ROC eğrisine göre elde edilen spesifite ve sensitivite değerleri TOS ve OSI parametrelerinin DVT'nin tanısında kullanılabilecek birer belirteç olabileceğini göster-mektedir. Aynı zamanda oksidatif stres belirteçlerinin belirlenmesi hastalarda oksidatif stresin düzeltilmesi için klinisyenlere gerekli önlemleri alabilmeleri için yol gösterici olabilir. Anahtar Kelimeler: Derin ven trombozu, oksidatif stres, toplam antioksidan durum, toplam oksidan durum Çıkar Çatışması: Yazarların çıkar çatışması yoktur.

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Section: Discussionsupporting

confidence: 42%

Evaluation of oxidative stress balance in acute deep vein thrombosis

et al. 2015

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“…Aging is characterized by several alterations in molecules, cells and tissues that lead to a progressive decline of the physiological function and loss of resistance [1]. A typical modification occurring in aging is the gradual imbalance of the oxidative stress: the Free Radical Theory of Aging first developed and described in 1956 [2] states that aging is characterized by a high production of reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Effect of Functional Fitness on Plasma Oxidation Level in Elders: Reduction of the Plasma Oxidants and Improvement of the Antioxidant Barrier

Gamberi¹

2018

AJSS

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Aging is characterized by a progressive decline in the physiological function due to the gradual alteration of molecules, cells and tissues. Reactive oxygen species (ROS) are the by-product of aerobic metabolism, and their increase is physiologically counteracted by the activation of the antioxidant machinery. A typical hallmark of aging is the imbalance of such equilibrium, due to either an increase of the amount of radicals or a failure of the antioxidant system. Literature reports that physical exercise is able to restore and maintain the homeostasis of oxidants and antioxidants during aging. Recently, growing interest has been turned to functional fitness, a special physical activity aimed to enhance the ability to perform everyday tasks, such as dressing, climbing stairs and preparing meals. The aim of this work was to assess whether a 24 weeksfunctional fitness program carried out on 28 elderly participants (57-86 years old) could be able to improve their oxidative status. For this purpose, dROMs (diacron Reactive Oxygen Metabolites) and BAP (Biological Antioxidant Potential) were analysed at the beginning and at the end of the study. Furthermore, both plasma and saliva protein carbonylation levels were explored through proteomics analysis.

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“…Aging is a normal process that can be characterized as an association of many deleterious alterations in molecules, cells, and tissues, culminating in reduced efficacy of physiological functions, and loss of resistance or adaptability to stress (da Cruz et al, 2014). The Free Radical Theory of Aging proposed by Denham Harman (Harman, 1956) stipulates that high production of reactive oxygen species (ROS), such as superoxide anions (

O_{2}^{- .}

), which can promote oxidative damage, culminating in cardiovascular injuries (Münzel et al, 2010; da Cruz et al, 2014; Wu et al, 2014; Mikhed et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…The Free Radical Theory of Aging proposed by Denham Harman (Harman, 1956) stipulates that high production of reactive oxygen species (ROS), such as superoxide anions (

O_{2}^{- .}

), which can promote oxidative damage, culminating in cardiovascular injuries (Münzel et al, 2010; da Cruz et al, 2014; Wu et al, 2014; Mikhed et al, 2015). The balance between pro and antioxidant activity is well-established as an important physiological regulator of blood pressure (BP), and has an important role in the pathogenesis of hypertension (HT; Roberts and Sindhu, 2009; Virdis et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Influence of Estimated Training Status on Anti and Pro-Oxidant Activity, Nitrite Concentration, and Blood Pressure in Middle-Aged and Older Women

et al. 2017

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The purpose of this study was to compare the association between anti and pro-oxidant activity, nitrite concentration, and blood pressure (BP) in middle-aged and older women with different levels of estimated training status (TS). The sample consisted of 155 females (50–84 years) who were submitted to a physical examination to evaluate estimated TS through the “Functional Fitness Battery Test,” BP measurements, and plasma blood samples to evaluate pro-oxidant and antioxidant activity and nitrite concentrations. Participants were separated by age into a middle-aged group (<65 years) and an older (≥65 years) group and then subdivided in each group according to TS. Blood biochemistry was similar between groups. On the other hand, protein oxidation was lower in participants with higher TS, independent of age. Older females with higher TS presented higher nitrite concentrations, lower lipoperoxidation, and lower values of BP compared with those with lower TS. Lower GPx activity was observed in participants with higher TS compared with middle-aged with lower TS. Thus, our results suggest that good levels of TS may be associated with lower oxidative stress and higher nitrite concentration and may contribute to maintain normal or reduced blood pressure values.

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Oxidative stress and aging: correlation with clinical parameters

Abstract: Thus, it seemed that plasma antioxidant potential is a better predictor of successful aging in the elderly than oxidative damage parameters or plasma antioxidant enzyme activities.

Cited by 14 publications

References 22 publications

Evaluation of oxidative stress balance in acute deep vein thrombosis

Evaluation of oxidative stress balance in acute deep vein thrombosis

Effect of Functional Fitness on Plasma Oxidation Level in Elders: Reduction of the Plasma Oxidants and Improvement of the Antioxidant Barrier

Influence of Estimated Training Status on Anti and Pro-Oxidant Activity, Nitrite Concentration, and Blood Pressure in Middle-Aged and Older Women

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