Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

Bhattacharyya, Asima; Chattopadhyay, Ranajoy; Mitra, Sankar; Crowe, Sheila E.

doi:10.1152/physrev.00040.2012

Cited by 1,804 publications

(1,413 citation statements)

References 315 publications

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“…Superoxide, the precursor of most other ROS, is also a frequent by‐product of normal cellular metabolism. It is formed intracellularly by ‘leakage’ (premature outflow) of electrons from the mitochondrial respiratory chain or from microsomal redox‐active enzymes, and their subsequent reaction with oxygen (e.g., Bhattacharyya et al , 2014). Catalytic conversion of superoxide by superoxide dismutase results in the formation of hydrogen peroxide (H 2 O 2 ), which is relatively stable in solution.…”

Section: Iron Functions and Oxidative Stressmentioning

confidence: 99%

Safety and benefits of antenatal oral iron supplementation in low‐income countries: a review

2017

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SummaryThe World Health Organization recommends universal iron supplementation of 30–60 mg/day in pregnancy but coverage is low in most countries. Its efficacy is uncertain, however, and there has been a vigorous debate in the last decade about its safety, particularly in areas with a high burden of malaria and other infectious diseases. We reviewed the evidence on the safety and efficacy of antenatal iron supplementation in low‐income countries. We found no evidence that daily supplementation at a dose of 60 mg leads to increased maternal Plasmodium infection risk. On the other hand, recent meta‐analyses found that antenatal iron supplementation provides benefits for maternal health (severe anaemia at postpartum, blood transfusion). For neonates, there was a reduced prematurity risk, and only a small or no effect on birth weight. A recent trial showed, however, that benefits of antenatal iron supplementation on maternal and neonatal health vary by maternal iron status, with substantial benefits in iron‐deficient women. The benefits of universal iron supplementation are likely to vary with the prevalence of iron deficiency. As a consequence, the balance between benefits and risks is probably more favourable in low‐income countries than in high‐income countries despite the higher exposure to infectious pathogens.

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Section: Iron Functions and Oxidative Stressmentioning

confidence: 99%

Safety and benefits of antenatal oral iron supplementation in low‐income countries: a review

2017

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“…For testing statistical significance after testing the normality of the its pro-oxidative effect and impairment of anti-oxidative protection. The superoxide dismutase, glutathione peroxidase and catalase enzymes are involved in protecting cells from the harmful effects of oxygen radicals (22,23). The pathogenesis of numerous gastrointestinal diseases, such as peptic ulcer, gastrointestinal carcinoma and inflammatory bowel disease, partly results from oxidative stress (22).…”

Section: Resultsmentioning

confidence: 99%

“…The superoxide dismutase, glutathione peroxidase and catalase enzymes are involved in protecting cells from the harmful effects of oxygen radicals (22,23). The pathogenesis of numerous gastrointestinal diseases, such as peptic ulcer, gastrointestinal carcinoma and inflammatory bowel disease, partly results from oxidative stress (22). Matte et al (24) noted the occurrence of oxidative stress in the liver of homocysteine-treated rats.…”

Section: Resultsmentioning

confidence: 99%

The Effects of Subchronic Methionine Overload Administered Alone or Simultaneously with L-cysteine or N-acetyl-L-cysteine on Body Weight, Homocysteine Levels and Biochemical Parameters in the Blood of Male Wistar Rats

Mićović

Stamenković

Nikolić

et al. 2016

Serbian Journal of Experimental and Clinical Research

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Hyperhomocysteinemia (HHC), both basal and after methionine load, may occur due to genetic disorders or defi ciencies of nutrients that aff ect the remethylation or transsulphuration pathways during methionine metabolism. HHC is involved in the pathogenesis of many illnesses as a SAŽETAK Hiperhomocisteinemija (HHC), kako bazalna tako i nakon ABBREVIATIONSAHDL -direct high-density cholesterol; ALB -albumin; ALP -alkaline phosphatase; ALT -alanine aminotransferase;AMY -amylase; AST -aspartate aminotransferase;bw -body weight BUN -blood urea nitrogen;Ca -calcium; Cl -chloride; CHOL -cholesterol; CREA -creatinine; ECL -electrochemiluminescence immunoassay system; GLUC -glucose; GGT -gamma glutamyl transferase;GSH -glutathione;Hcy -homocysteine; HHC -hyperhomocysteinemia; IBCT -total iron binding capacity;MET -DL-methionine; NAC -N-acetyl-L-cysteine; Na -sodium; RCRP -C-reactive protein; ROS -reactive oxygen species; TBI -total bilirubin; TGL -triglyceride; tHcy -total homocysteine; TP -total protein; URCA -uric acid

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“…Food particles and disease causing organisms may cause inflammation by activating certain unregulated factors within the colon epithelium. The infiltration of polymorphonuclear neutrophils (PMNs) and macrophages can synthesize inflammatory cytokines (and other mediators) that contribute further to oxidative stress [29]. In physiological conditions, exogenous (dietary) and endogenous enzymatic antioxidants protect tissues from dangers posed by ROS.…”

Section: Discussionmentioning

confidence: 99%

Trivalent Chromium Promotes Healing of Experimental Colitis in Mice by Suppression of Inflammation and Oxidative Stress

Odukanmi¹,

Salami²,

Koda³

et al. 2017

JBM

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Ulcerative colitis (UC) has reactive oxygen species (ROS) and immunologic pathways implicated in its pathogenesis. The search for new therapeutic protocols in managing UC is tailored in suppressing or preventing these pathways. The influence of trivalent chromium (Cr 3+ ), an essential mineral on experimental colitis was investigated. Mice were grouped into 3; group 1 (control) received clean drinking water while groups 2 and 3 received 10 and 100 ppm Cr 3+ respectively for 12 weeks through drinking water. After Cr 3+ administration, 5 animals per group were sacrificed on day 0. Thereafter, experimental colitis was induced intra-rectally using acetic acid (4%, 0.3mL) and 5 mice per group were subsequently sacrificed on days 3, 7 and 14. Blood and colonic tissues were obtained and processed appropriately. Blood Cr 3+ level, haematological variables, gross and microscopic colitis scores, colonic myeloperoxidase (MPO), Superoxide Dismutase (SOD) and malondialdehyde (MDA) levels were determined using standard methods. Colon cytokine mRNA genes were quantified using real-time PCR. There was a significant decrease in colon gross and histology scores on days 3 and 7 in chromium treated compared with control. The MPO and MDA in chromium groups reduced significantly compared with control while SOD activities increased significantly in Cr 3+ groups compared with control. Total RNA increased in chromium groups compared with control on day 3 post-colitis. There was up-regulation of IL-10, down-regulation of TNF-α and IFN-λ in chromium administered groups compared with control. Chromium enhanced healing of colitis by suppression of ROS, inflammation and promotion of antioxidant activities.

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Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases

Cited by 1,804 publications

References 315 publications

Safety and benefits of antenatal oral iron supplementation in low‐income countries: a review

Safety and benefits of antenatal oral iron supplementation in low‐income countries: a review

The Effects of Subchronic Methionine Overload Administered Alone or Simultaneously with L-cysteine or N-acetyl-L-cysteine on Body Weight, Homocysteine Levels and Biochemical Parameters in the Blood of Male Wistar Rats

Trivalent Chromium Promotes Healing of Experimental Colitis in Mice by Suppression of Inflammation and Oxidative Stress

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