Trivalent Chromium Promotes Healing of Experimental Colitis in Mice by Suppression of Inflammation and Oxidative Stress

Odukanmi, Olugbenga Adeola; Salami, Adeola Temitope; Koda, Koyo; Morakinyo, Oyenike Lola; Olaleye, Samuel Babafemi

doi:10.4236/jbm.2017.58009

Cited by 7 publications

(6 citation statements)

References 37 publications

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“…Cr content in H. aspersa Müller foot tissue lyophilisate was ten times higher comparing to the content in dry matter of oysters edible parts [ 37 ]. In the study of Odukanmi et al, trivalent Cr improved colitis healing in mice by promotion of antioxidant activities, suppression of ROS and inflammation [ 60 ]. In turn, chronic administration of hexavalent Cr in high doses elicited alimentary cancers in mouse models [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Influence of Extracts from Snail Helix aspersa Müller on the Colon Cancer Cell Line Caco-2

Matusiewicz

Kosieradzka

Niemiec

et al. 2018

IJMS

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Colorectal cancer is the third most widely diagnosed cancer. Extracts from snails may modulate growth and development of colorectal cancer cells. The objective of this study was to determine the chemical composition of tissues derived from Helix aspersa Müller and red-ox properties of tissue extracts. Then, the influence of extracts and their fractions of different molecular weights on viability of Caco-2 cells was examined. Tissue lyophilisates contained antioxidants that could be important in the prevention of colorectal cancer. Moreover, we confirmed the presence of a wide array of compounds that might be used in treatment of this disease. The decrease of cell viability after the application of extracts from lyophilized mucus and foot tissues was affirmed. The effect of extract from mucus could be related to the content of some proteins and peptides, proper essential amino acids (EAA)/non-essential amino acids (NEAA) ratio, Met restriction and the presence of Cu, Ca, Zn, Se. The influence of the extract from foot tissues could be assigned additionally to the presence of eicosapentaenoic, α-linolenic, linoleic and γ-linolenic acids. The opposite effect was demonstrated by extract from lyophilized shells which increased cell viability. Further studies are needed to know whether dietary supplying of H. aspersa Müller tissues can be used as an approach in colorectal cancer management.

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Section: Discussionmentioning

confidence: 99%

In Vitro Influence of Extracts from Snail Helix aspersa Müller on the Colon Cancer Cell Line Caco-2

Matusiewicz

Kosieradzka

Niemiec

et al. 2018

IJMS

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“…It not only increases insulin sensitivity [26,27] and improves lipid metabolism [28] but also reduces the oxidative stress [29], body weight, and body fat mass [30] in those patients. Several studies have been reported that chromium (III) increases the cellular antioxidant capacity in mice and rats [31,32]. Recently, it also has been shown that chromium could inhibit hepatic steatosis in rats given a high-fat diet [33].…”

Section: Introductionmentioning

confidence: 99%

Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial

Kooshki

Moradi

Karimi

et al. 2020

European Journal of Gastroenterology &Amp; Hepatology

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Objective Nonalcoholic fatty liver disease (NAFLD) is a complicated disease and is considered as a severe global health problem affecting 30% of adults worldwide. The present study aimed to evaluate changes in oxidative stress, adipokines, liver enzyme, and body composition following treatment with chromium picolinate (CrPic) among patients with NAFLD. Participants and methods The current randomized, double-blind, placebo-controlled study was conducted on 46 NAFLD patients with the age range of 20–65 years. Patients were randomly classified into two groups, receiving either 400 µg CrPic tablets in two divided doses of 200 µg (23 patients) or placebo (23 patients) daily for 12 weeks. The participants’ body composition and biochemical parameters were evaluated at the baseline and after 12 weeks. Results Serum levels of liver enzymes reduced significantly only in the CrPic group (P < 0.05 for all), but not between the groups after the intervention. Besides, there were significant differences between the study groups regarding body weight and body fat mass, total antioxidant capacity, superoxide dismutase, malondialdehyde, leptin, and adiponectin post-intervention (P = 0.017, P = 0.032, P = 0.003, P = 0.023, P = 0.012, P = 0.003, and P = 0.042, respectively). However, glutathione peroxidase and resistin levels did not differ significantly between groups (P = 0.127 and P = 0.688, respectively). Discussion and conclusion This study showed that consuming 400 µg/day of CrPic for 12 weeks in patients with NAFLD causes a significant change in leptin, adiponectin, oxidative stress (expect glutathione peroxidase), and body weight, compared to baseline. Nevertheless, it does not affect liver enzymes. Therefore, the CrPic supplementation may improve adipokines, some anthropometric indices, and oxidative stress in patients with NAFLD.

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“…This ferent in comparison to untreated RA rats (P ≤ 0.05), ## significantly different in comparison to untreated RA rats (P ≤ 0.001), @ significant difference between both treated groups (P ≤ 0.05), @@ significant difference between both treated groups (P ≤ 0.001) (Odukanmi et al 2017). Cr (III) also showed up-regulatory effects on other anti-inflammatory cytokines (Moradi et al 2019).…”

Section: Discussionmentioning

confidence: 84%

“…This study revealed that Cr (III) up-regulates FOXP3 expression which means subsequent remission of RA (Kanjana et al 2020 ) and this goes in line with the up-regulation of the anti-inflammatory cytokine IL 10 (Greenhill et al 2014 ) in Cr (III) treated RA group that was even exceeding that of prednisolone in this study. IL 10 increase after Cr (III) supplementation was shown in the study of Odukanmi O. et, al who used Cr (III) in induced inflammatory colitis (Odukanmi et al 2017 ). Cr (III) also showed up-regulatory effects on other anti-inflammatory cytokines (Moradi et al 2019 ).…”

Section: Discussionmentioning

confidence: 93%

Trivalent chromium supplementation ameliorates adjuvant induced rheumatoid arthritis through up-regulation of FOXP3 and decrease in synovial Cathepsin G expression

et al. 2022

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Background Rheumatoid arthritis (RA) is a known debilitating autoimmune disease. Immune-suppressants that are used for disease treatment have serious side effects, therefore, trivalent chromium (Cr (III)); which has shown evidence of its influences on some inflammatory pathways and cytokines; was used in this study for the first time to be assessed for its therapeutic effect in RA rat model and was compared to prednisolone in a trial to find a treatment with lesser side effects. Methods Adult male albino rats were randomly divided into four groups: normal, untreated RA, prednisolone treated RA (1.25 mg/kg/day) and Cr (III) treated RA groups (80 μg/kg/day), induction of RA was done by subcutaneous complete Freund adjuvant injection. Study duration was 4 weeks throughout which arthritis scoring and weight measurement were pursued. Histopathological examination and immunohistochemical FOXP3 assessment were done for joint biopsies. Serum inflammatory markers (interleukin 17, interleukin 10, CRP) and synovial erosive arthritis marker (Cathepsin G) were measured. HDL and non-HDL cholesterol were estimated as well. Results Cr (III) treatment showed marked clinical and histopathological improvement, also astonishing anti-inflammatory effects (increase in FOXP3 expression and interleukin 10, with decrease in interleukin 17, CRP and synovial Cathepsin G) to the extent that Cr (III) effects on inflammation abolishment were comparable to that of prednisolone and even better at some aspects. Moreover, Cr (III) was protective from side effects, i.e., weight gain and dyslipidemia that were seen with prednisolone treatment. Conclusions Cr (III) is promising in treating RA and it lacks some side effects of accustomed immune-modulatory agents including prednisolone. Further experimental studies and clinical trials should be held to see the efficacy of Cr (III) in different doses and to assess its long term side effects when used for rheumatoid arthritis and other autoimmune diseases treatment.

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Trivalent Chromium Promotes Healing of Experimental Colitis in Mice by Suppression of Inflammation and Oxidative Stress

Cited by 7 publications

References 37 publications

In Vitro Influence of Extracts from Snail Helix aspersa Müller on the Colon Cancer Cell Line Caco-2

In Vitro Influence of Extracts from Snail Helix aspersa Müller on the Colon Cancer Cell Line Caco-2

Chromium picolinate balances the metabolic and clinical markers in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial

Trivalent chromium supplementation ameliorates adjuvant induced rheumatoid arthritis through up-regulation of FOXP3 and decrease in synovial Cathepsin G expression

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