Oxidative stress-amplified nanomedicine for intensified ferroptosis-apoptosis combined tumor therapy

Yu, Mian; Yu, Jiayin; Yi, Yunfei; Chen, Ting; Liu, Yu; Zeng, Weiwei; Ouyang, Xiaolong; Huang, Chenyi; Sun, Shengjie; Wang, Yang; Liu, Yuanqi; Lin, Chuchu; Wu, Meiying; Mei, Lin

doi:10.1016/j.jconrel.2022.04.047

Cited by 44 publications

(28 citation statements)

References 50 publications

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“…Oxidative stress-dependent ferroptosis can be regulated by GDF15 post-spinal cord injury (25). It was also reported that the effects of nanomedicine in targeting ferroptosis and apoptosis can be enhanced by oxidative stress (26). In recent years, some studies focused on constructing oxidative stress or ferroptosis-related risk models for predicting patient survival and immune landscapes in various types of malignant tumors (27)(28)(29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

A novel oxidative stress- and ferroptosis-related gene prognostic signature for distinguishing cold and hot tumors in colorectal cancer

Wang

Xu²,

Dai³

et al. 2022

Front. Immunol.

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Oxidative stress and ferroptosis exhibit crosstalk in many types of human diseases, including malignant tumors. We aimed to develop an oxidative stress- and ferroptosis-related gene (OFRG) prognostic signature to predict the prognosis and therapeutic response in patients with colorectal cancer (CRC). Thirty-four insertion genes between oxidative stress-related genes and ferroptosis-related genes were identified as OFRGs. We then performed bioinformatics analysis of the expression profiles of 34 OFRGs and clinical information of patients obtained from multiple datasets. Patients with CRC were divided into three OFRG clusters, and differentially expressed genes (DEGs) between clusters were identified. OFRG clusters correlated with patient survival and immune cell infiltration. Prognosis-related DEGs in three clusters were used to calculate the risk score, and a prognostic signature was constructed according to the risk score. In this study, patients in the low-risk group had better prognosis, higher immune cell infiltration levels, and better responses to fluorouracil-based chemotherapy and immune checkpoint blockade therapy than high-risk patients; these results were successfully validated with multiple independent datasets. Thus, low-risk CRC could be defined as hot tumors and high-risk CRC could be defined as cold tumors. To further identify potential biomarkers for CRC, the expression levels of five signature genes in CRC and adjacent normal tissues were further verified via an in vitro experiment. In conclusion, we identified 34 OFRGs and constructed an OFRG-related prognostic signature, which showed excellent performance in predicting survival and therapeutic responses for patients with CRC. This could help to distinguish cold and hot tumors in CRC, and the results might be helpful for precise treatment protocols in clinical practice.

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Section: Discussionmentioning

confidence: 99%

A novel oxidative stress- and ferroptosis-related gene prognostic signature for distinguishing cold and hot tumors in colorectal cancer

Wang

Xu²,

Dai³

et al. 2022

Front. Immunol.

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“…The results show that the activity of intracellular CAT was effectively suppressed after CaS@PP and I-CaS@PP treatments due to the generated H 2 S, which would be further inhibited with exposure to laser irradiation, proving that ICG-mediated thermal energy stimulated H 2 S production. It is well known that CAT is an antioxidant enzyme overexpressed in tumor cells that catalyzes H 2 O 2 into water and oxygen, which influences cancer progression and strengthens resistance to various therapies 36 , 37 , 38 , 39 , 40 , 41 , 42 . Therefore, the decrease of CAT activity affected by H 2 S may contribute to inhibit the decomposition of harmful substance H 2 O 2 and elevate intracellular oxidative stress 16 .…”

Section: Resultsmentioning

confidence: 99%

Biodegradable calcium sulfide-based nanomodulators for H2S-boosted Ca2+-involved synergistic cascade cancer therapy

Lin

Huang

Shi

et al. 2022

Acta Pharmaceutica Sinica B

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“…A tannic acid (TA) network with a polyphenol structure has been shown to reduce Fe 3+ to Fe 2+ [65,66]. Exploiting this property, Yu et al have designed a self-assembling nanoplatform (p53/Ce6@ZF-T, Figure 5a) [67]. The nanoparticles are composed of a p53 plasmid-complexed Ce6-poly(amidoamine), Fe 2+ -containing mesoporous zeolitic imidazolate framework-8, and TA.…”

Section: Combining Pdt and Metal-ion-induced Ferroptosismentioning

confidence: 99%

Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy

Zeping

Zheng

Kamei

et al. 2022

Acta Materia Medica

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Current anticancer treatments have many limitations to achieving high efficacy. Hence, novel strategies that broaden therapeutic prospects must urgently be developed. Ferroptosis is an iron-dependent form of non-apoptotic programmed cell death that is induced by cellular antioxidative system inhibition. Photodynamic therapy (PDT) uses photosensitizers to generate reactive oxygen species and aggravate oxidative stress in tumor cells. Combining ferroptosis with PDT cooperatively regulates intracellular redox homeostasis, thus increasing cancer cell susceptibility to oxidative stress and yielding synergistic anticancer effects. In this review, various strategies for combining ferroptosis with PDT are comprehensively summarized and discussed, including mono-PDT and PDT-induced ferroptosis, combining PDT with small-molecule ferroptosis inducers, and combining PDT with metal-ion-induced ferroptosis. Additionally, the possibility of combining ferroptosis and PDT with other anti-tumor therapies is discussed. Finally, the prospects and challenges of combining ferroptosis with PDT in clinical cancer treatment are addressed. With increased understanding of the superiority of combination PDT with ferroptosis for cancer treatment, we hope that drug delivery systems based on this strategy will be further developed to increase anticancer efficiency and achieve successful clinical translation.

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Oxidative stress-amplified nanomedicine for intensified ferroptosis-apoptosis combined tumor therapy

Cited by 44 publications

References 50 publications

A novel oxidative stress- and ferroptosis-related gene prognostic signature for distinguishing cold and hot tumors in colorectal cancer

A novel oxidative stress- and ferroptosis-related gene prognostic signature for distinguishing cold and hot tumors in colorectal cancer

Biodegradable calcium sulfide-based nanomodulators for H2S-boosted Ca2+-involved synergistic cascade cancer therapy

Recent progress in cancer therapy based on the combination of ferroptosis with photodynamic therapy

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