Biodegradable calcium sulfide-based nanomodulators for H2S-boosted Ca2+-involved synergistic cascade cancer therapy

Lin, Chuchu; Huang, Chenyi; Shi, Zhaoqing; Ou, Meitong; Sun, Shengjie; Yu, Mian; Chen, Ting; Yi, Yunfei; Ji, Xiaoyuan; Lv, Feng; Wu, Meiying; Mei, Lin

doi:10.1016/j.apsb.2022.08.008

Cited by 22 publications

(16 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The heat resistance of the tumor arises from the high expression of HSPs . As presented in Figure f, compared with the PBS + L group, the FTEP + L groups showed higher expression of HSP70 due to the increased temperature.…”

Section: Resultsmentioning

confidence: 90%

“…30,31 The ultrasmall gas molecules could freely invade the tumor stroma and penetrate biological membranes, inducing acute toxicity through miRNA regulation, mitochondrial damage, or uncontrolled intracellular acidification. 32,33 Combining CDT with H 2 S gas therapy could first achieve an enhanced antitumor effect by facilitating the valence conversion of Fe 3+ to Fe 2+ , thus promoting the efficiency of Fenton reactions to strengthen the CDT effect. 34 On the one hand, H 2 S can inhibit catalase activity, thus alleviating the consumption of intratumoral hydrogen peroxide (H 2 O 2 ).…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Tumor Microenvironment-Responsive One-for-All Molecular-Engineered Nanoplatform Enables NIR-II Fluorescence Imaging-Guided Combinational Cancer Therapy

Wu,

Liu,

et al. 2023

Anal. Chem.

View full text Add to dashboard Cite

The activable NIR-based phototheranostic nanoplatform (NP) is considered an efficient and reliable tumor treatment due to its strong targeting ability, flexible controllability, minimal side effects, and ideal therapeutic effect. This work describes the rational design of a second near-infrared (NIR-II) fluorescence imaging-guided organic phototheranostic NP (FTEP-TBFc NP). The molecular-engineered phototheranostic NP has a sensitive response to glutathione (GSH), generating hydrogen sulfide (H 2 S) gas, and delivering ferrocene molecules in the tumor microenvironment (TME). Under 808 nm irradiation, FTEP-TBFc could not only simultaneously generate fluorescence, heat, and singlet oxygen but also greatly enhance the generation of reactive oxygen species to improve chemodynamic therapy (CDT) and photodynamic therapy (PDT) at a biosafe laser power of 0.33 W/cm 2 . H 2 S inhibits the activity of catalase and cytochrome c oxidase (COX IV) to cause the enhancement of CDT and hypothermal photothermal therapy (HPTT). Moreover, the decreased intracellular GSH concentration further increases CDT's efficacy and downregulates glutathione peroxidase 4 (GPX4) for the accumulation of lipid hydroperoxides, thus causing the ferroptosis process. Collectively, FTEP-TBFc NPs show great potential as a versatile and efficient NP for specific tumor imaging-guided multimodal cancer therapy. This unique strategy provides new perspectives and methods for designing and applying activable biomedical phototheranostics.

show abstract

Section: Resultsmentioning

confidence: 90%

Section: ■ Introductionmentioning

confidence: 99%

Tumor Microenvironment-Responsive One-for-All Molecular-Engineered Nanoplatform Enables NIR-II Fluorescence Imaging-Guided Combinational Cancer Therapy

Wu,

Liu,

et al. 2023

Anal. Chem.

View full text Add to dashboard Cite

show abstract

“…Mei et al developed a biodegradable nanomodulator (I-CaS@PP) by encapsulating CaS and indocyanine green (ICG) into PLGA-PEG. [113] I-CaS@PP can release H 2 S and Ca 2+ controllably in the acidic tumor microenvironment for synergistic cascade cancer therapy. The released H 2 S and Ca 2+ can promote abnormal retention of Ca 2+ in cells, leading to mitochondria destruction and oxidative stress amplification.…”

Section: Tumorsmentioning

confidence: 99%

Current Status and Future Prospects of Hydrogen Sulfide Donor‐Based Delivery Systems

Chen

2023

Advanced Therapeutics

View full text Add to dashboard Cite

Nowadays, hydrogen sulfide (H2S) is regarded as an endogenous gaseous signaling molecule in mammals. As a gas transmitter, it induces important biological effects in many physiological and pathological processes, and possesses great therapeutic potentials. However, this bioactive gas has concentration‐related toxicity, rapid evaporation, and high reactivity, making it inconvenient to use as a therapeutic agent. As an exogenous source of H2S, various H2S donors are developed to release H2S after triggering the response under specific conditions, so as to supplement the level of H2S in the body. Meanwhile, to enhance the therapeutic efficacy and reduce the possible toxicities of the H2S donors, various new materials or methods for H2S delivery are studied, realizing sustained/controlled release profiles as well as achieving triggered, long‐term, local or targeted delivery approaches for the gas. This review summarizes the representative H2S donors and the latest progress of hydrogen sulfide donor‐based delivery systems, and the applications of such delivery systems in a series of target diseases that are suitable and expected to be treated by H2S, in order to provide reference for the design of secure and efficient H2S donor drug delivery system. In addition, the future of this field is also prospected.

show abstract

“…Owing to their tunable plasmonic adsorption, as well as their quenching capability, gold nanoparticles have been recognized as an ideal Förster resonance energy transfer (FRET) probe. − With in-depth research, a more advantageous strategy is converting nanoprobe into a theranostics platform that simultaneously delivers anticancer drugs and experiences a signal change following drug liberation. While chemotherapy still plays an important role in cancer treatment, the effectiveness of chemotherapy is severely hindered by the emergence of multidrug resistance. , Synergistic therapy combining chemotherapy with other therapeutic methodologies was reported to be a highly efficient therapeutic way, which can alleviate drug resistance and systemic toxicity. − siRNA can downregulate gene expression in several model systems and is one of the most popular methodologies in a therapeutic setting. − Thus, the development of nanoplatforms with the capacity of stimuli-responsive codelivery of chemotherapeutic drugs and siRNA is highly desirable due to their ability to target multiple cancer survival mechanisms with synergistic anticancer effects. − While various kinds of inorganic and organic materials were developed for multidrug delivery, − mesoporous silica-based nanocomposites are preferred cargo nanocarriers owing to their tunable pore size, ease of surface functionalization, biocompatibility, and structural control. − The development of multifunctional dual-mesoporous silica-based nanocarriers has been recognized as an ideal candidate for codelivery and multidrug release monitoring. , …”

Section: Introductionmentioning

confidence: 99%

FRET-Modulated Fluorescence Lifetime-Traceable Nanocarriers for Multidrug Release Monitoring and Synergistic Therapy

Zhou,

Chen,

Luo

et al. 2023

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

In situ monitoring multidrug release in complex cellular microenvironments is significant, and currently, it is still a great challenge. In this work, a smart nanocarrier with the capability of codelivery of small molecules and gene materials as well as with Forster resonance energy transfer (FRET)-modulated fluorescence lifetime is fabricated by integrating gold nanoparticles (the acceptor) into dual-mesoporous silica loaded with multiple drugs (the donor). Once internalized into tumor cells, in weakly acidic environments, the conformation switch of the polymer grafted on nanocarriers causes its shedding from the mesopores, triggering the release of drugs. Simultaneously, based on the strong overlap between the emission spectrum of donors and the absorption spectrum of the acceptors, any slight fluctuation of the dissociation of the drugs from nanocarriers can result in a change in the FRET-modulated lifetime signal due to the extraordinarily sensitive FRET signal to the separation distance between donors and acceptors. All these implied the potential applications of this nanoplatform in various biomedical fields that require the codelivery and real-time monitoring of multidrug-based synergistic therapy.

show abstract

Biodegradable calcium sulfide-based nanomodulators for H2S-boosted Ca2+-involved synergistic cascade cancer therapy

Cited by 22 publications

References 45 publications

Tumor Microenvironment-Responsive One-for-All Molecular-Engineered Nanoplatform Enables NIR-II Fluorescence Imaging-Guided Combinational Cancer Therapy

Tumor Microenvironment-Responsive One-for-All Molecular-Engineered Nanoplatform Enables NIR-II Fluorescence Imaging-Guided Combinational Cancer Therapy

Current Status and Future Prospects of Hydrogen Sulfide Donor‐Based Delivery Systems

FRET-Modulated Fluorescence Lifetime-Traceable Nanocarriers for Multidrug Release Monitoring and Synergistic Therapy

Contact Info

Product

Resources

About