2022
DOI: 10.1016/j.apsb.2022.08.008
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Biodegradable calcium sulfide-based nanomodulators for H2S-boosted Ca2+-involved synergistic cascade cancer therapy

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Cited by 22 publications
(16 citation statements)
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“…The heat resistance of the tumor arises from the high expression of HSPs . As presented in Figure f, compared with the PBS + L group, the FTEP + L groups showed higher expression of HSP70 due to the increased temperature.…”
Section: Resultsmentioning
confidence: 90%
See 1 more Smart Citation
“…The heat resistance of the tumor arises from the high expression of HSPs . As presented in Figure f, compared with the PBS + L group, the FTEP + L groups showed higher expression of HSP70 due to the increased temperature.…”
Section: Resultsmentioning
confidence: 90%
“…30,31 The ultrasmall gas molecules could freely invade the tumor stroma and penetrate biological membranes, inducing acute toxicity through miRNA regulation, mitochondrial damage, or uncontrolled intracellular acidification. 32,33 Combining CDT with H 2 S gas therapy could first achieve an enhanced antitumor effect by facilitating the valence conversion of Fe 3+ to Fe 2+ , thus promoting the efficiency of Fenton reactions to strengthen the CDT effect. 34 On the one hand, H 2 S can inhibit catalase activity, thus alleviating the consumption of intratumoral hydrogen peroxide (H 2 O 2 ).…”
Section: ■ Introductionmentioning
confidence: 99%
“…Mei et al developed a biodegradable nanomodulator (I-CaS@PP) by encapsulating CaS and indocyanine green (ICG) into PLGA-PEG. [113] I-CaS@PP can release H 2 S and Ca 2+ controllably in the acidic tumor microenvironment for synergistic cascade cancer therapy. The released H 2 S and Ca 2+ can promote abnormal retention of Ca 2+ in cells, leading to mitochondria destruction and oxidative stress amplification.…”
Section: Tumorsmentioning
confidence: 99%
“…Owing to their tunable plasmonic adsorption, as well as their quenching capability, gold nanoparticles have been recognized as an ideal Förster resonance energy transfer (FRET) probe. With in-depth research, a more advantageous strategy is converting nanoprobe into a theranostics platform that simultaneously delivers anticancer drugs and experiences a signal change following drug liberation. While chemotherapy still plays an important role in cancer treatment, the effectiveness of chemotherapy is severely hindered by the emergence of multidrug resistance. , Synergistic therapy combining chemotherapy with other therapeutic methodologies was reported to be a highly efficient therapeutic way, which can alleviate drug resistance and systemic toxicity. siRNA can downregulate gene expression in several model systems and is one of the most popular methodologies in a therapeutic setting. Thus, the development of nanoplatforms with the capacity of stimuli-responsive codelivery of chemotherapeutic drugs and siRNA is highly desirable due to their ability to target multiple cancer survival mechanisms with synergistic anticancer effects. While various kinds of inorganic and organic materials were developed for multidrug delivery, mesoporous silica-based nanocomposites are preferred cargo nanocarriers owing to their tunable pore size, ease of surface functionalization, biocompatibility, and structural control. The development of multifunctional dual-mesoporous silica-based nanocarriers has been recognized as an ideal candidate for codelivery and multidrug release monitoring. , …”
Section: Introductionmentioning
confidence: 99%