Oxidative modifications of blood serum proteins in myasthenia gravis

Adamczyk-Sowa, Monika; Bieszczad-Bedrejczuk, Edyta; Galiniak, Sabina; Rozmilowska, Izabela; Czyżewski, Damian; Bartosz, Grzegorz; Sadowska-Bartosz, Izabela

doi:10.1016/j.jneuroim.2017.01.019

Cited by 22 publications

(16 citation statements)

References 38 publications

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“…Both MGO and GO are known to enhance oxidative stress in the human body. Recent reports suggest that increased glycation is associated with a higher prevalence of diabetes and related complications (Adamska et al, 2018;Rhee & Kim, 2018), lung (Khan et al, 2018) and breast cancer (Walter et al, 2018), myasthenia gravis (Adamczyk-Sowa et al, 2017), and neurodegenerative diseases (Pinkas & Aschner, 2016).…”

Section: Introductionmentioning

confidence: 99%

Health benefits of resveratrol administration

Aebisher²,

2019

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Resveratrol is a polyphenol which is abundant in grape skin and seeds. Sources of resveratrol in food also include wine, berries, and peanuts. This compound displays many properties including activity against glycation, oxidative stress, inflammation, neurodegeneration, several types of cancer, as well as aging. Due to the fact that resveratrol is generally well-tolerated, it is believed to be a promising compound in preventing many diseases such as diabetes and associated complications. Unfortunately, this compound exhibits low bioavailability and solubility. The aim of this review is to summarize recent information from in vitro and in vivo studies on animals and humans on the multiple effects of resveratrol on health and benefits of its intake.

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Section: Introductionmentioning

confidence: 99%

Health benefits of resveratrol administration

Aebisher²,

2019

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“…Oxidative stress has also been reported in MG [20]. This could be demonstrate by assessing oxidative modification of some serum proteins [20,21].…”

Section: Resultsmentioning

confidence: 89%

“…No independent parameters of oxidative damage estimation were tested in our case. Demonstrating of systemic oxidative stress could suggest therapeutic use of antioxidants as an adjuvant treatment, improving the evolution and quality of life in MG [20,22].…”

Section: Resultsmentioning

confidence: 99%

Acetylcholinesterase Inhibitors Test Confirmed Myasthenia Gravis in Psychosis Remitted by Aripiprazole

Teodorescu¹,

Ifteni²,

Petric³

et al. 2018

Rev. Chim.

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Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disease affecting the neuromuscular junction and causes weakness in the skeletal muscles. The acetylcholine receptor is usually attacked in skeletal muscles, but other components of neuromuscular junction, such as muscle-specific receptor tyrosine kinase, may be affected. MG can be life-threatening when the respiratory muscles are involved. The first symptom in about 2 out of 3 cases is the damage of the extrinsic eye muscles. The condition is treatable, so an early recognition is needed. Although there have been reports of associations between psychosis and myasthenia gravis it is unclear if psychotic symptoms in MG are an integral part of the various manifestations of this disease, or are due to another co-occurring distinct disorder. Sometimes psychotic episodes could disguise the simptoms of myastenia gravis, and delay the diagnosis.

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“…The main function of GSH is maintaining thiol groups of proteins in a reduced state, which is often necessary for preserving the functional activity of these proteins. It has been shown that the most probable primary object of ROS attack is proteins, and, according to this theory, fatty and nucleic acids are protected by proteins and therefore undergo oxidation at a later stage [51]. A mediator of biomolecule damage in cells is the hydroxyl radical (OH . )…”

Section: Discussionmentioning

confidence: 99%

Dysfunction of Salivary Glands, Disturbances in Salivary Antioxidants and Increased Oxidative Damage in Saliva of Overweight and Obese Adolescents

Zalewska

Kossakowska

Taranta-Janusz

et al. 2020

JCM

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Obesity is inseparably connected with oxidative stress. This process may disturb the functioning of the oral cavity, although the effect of oxidative stress on salivary gland function and changes in the qualitative composition of saliva are still unknown. Our study is the first to evaluate salivary redox homeostasis in 40 overweight and obese adolescents and in the age- and gender-matched control group. We demonstrated strengthening of the antioxidant barrier (superoxide dismutase, catalase, peroxidase, uric acid, total antioxidant capacity (TAC)) with a simultaneous decrease in reduced glutathione concentration in saliva (non-stimulated/stimulated) in overweight and obese teenagers compared to the controls. The concentration of the products of oxidative damage to proteins (advanced glycation end products), lipids (malondialdehyde, 4-hydroxynonenal) and DNA (8-hydroxydeoxyguanosine) as well as total oxidative status were significantly higher in both non-stimulated and stimulated saliva as well as plasma of overweight and obese adolescents. Importantly, we observed more severe salivary and plasma redox alterations in obese adolescents compared to overweight individuals. In the study group, we also noted a drop in stimulated salivary secretion and a decrease in total protein content. Interestingly, dysfunction of parotid glands in overweight and obese teenagers intensified with the increase of BMI. We also showed that the measurement of salivary catalase and TAC could be used to assess the central antioxidant status of overweight and obese adolescents.

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Oxidative modifications of blood serum proteins in myasthenia gravis

Cited by 22 publications

References 38 publications

Health benefits of resveratrol administration

Health benefits of resveratrol administration

Acetylcholinesterase Inhibitors Test Confirmed Myasthenia Gravis in Psychosis Remitted by Aripiprazole

Dysfunction of Salivary Glands, Disturbances in Salivary Antioxidants and Increased Oxidative Damage in Saliva of Overweight and Obese Adolescents

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