Health benefits of resveratrol administration

Galiniak, Sabina; Aebisher, David; Bartusik‐Aebisher, Dorota

doi:10.18388/abp.2018_2749

Cited by 190 publications

(184 citation statements)

References 119 publications

(126 reference statements)

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“…RSV belongs to a stilbene class of polyphonic compounds, commonly found in grapes, berries, peanuts, and other plant foods. During the past two decades, RSV has been widely studied and associated with many potential health benefits [48,49]. RSV has been shown to promote endurance performance in mice [19][20][21] and exercise-induced cellular and functional adaptions of skeletal muscle in elderly people [22].…”

Section: Discussionmentioning

confidence: 99%

Pterostilbene Enhances Endurance Capacity via Promoting Skeletal Muscle Adaptations to Exercise Training in Rats

et al. 2020

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It has been demonstrated that skeletal muscle adaptions, including muscle fibers transition, angiogenesis, and mitochondrial biogenesis are involved in the regular exercise-induced improvement of endurance capacity and metabolic status. Herein, we investigated the effects of pterostilbene (PST) supplementation on skeletal muscle adaptations to exercise training in rats. Six-week-old male Sprague Dawley rats were randomly divided into a sedentary control group (Sed), an exercise training group (Ex), and exercise training combined with 50 mg/kg PST (Ex + PST) treatment group. After 4 weeks of intervention, an exhaustive running test was performed, and muscle fiber type transformation, angiogenesis, and mitochondrial content in the soleus muscle were measured. Additionally, the effects of PST on muscle fiber transformation, paracrine regulation of angiogenesis, and mitochondrial function were tested in vitro using C2C12 myotubes. In vivo study showed that exercise training resulted in significant increases in time-to-exhaustion, the proportion of slow-twitch fibers, muscular angiogenesis, and mitochondrial biogenesis in rats, and these effects induced by exercise training could be augmented by PST supplementation. Moreover, the in vitro study showed that PST treatment remarkably promoted slow-twitch fibers formation, angiogenic factor expression, and mitochondrial function in C2C12 myotubes. Collectively, our results suggest that PST promotes skeletal muscle adaptations to exercise training thereby enhancing the endurance capacity.

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Section: Discussionmentioning

confidence: 99%

Pterostilbene Enhances Endurance Capacity via Promoting Skeletal Muscle Adaptations to Exercise Training in Rats

et al. 2020

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“…Notwithstanding the substantial number of human and animal studies that support the beneficial and protective properties of RE [60,181,[219][220][221][222], there are not enough clinical studies that report on RE's harmful effects, which are indeed full of controversy. Moreover, the molecular mechanism of RE action needs to be better identified.…”

Section: Current Concerns and Recommendationsmentioning

confidence: 99%

Potential Adverse Effects of Resveratrol: A Literature Review

Shaito

Posadino

Younes

et al. 2020

IJMS

395

293

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Due to its health benefits, resveratrol (RE) is one of the most researched natural polyphenols. Resveratrol's health benefits were first highlighted in the early 1990s in the French paradox study, which opened extensive research activity into this compound. Ever since, several pharmacological activities including antioxidant, anti-aging, anti-inflammatory, anti-cancerous, anti-diabetic, cardioprotective, and neuroprotective properties, were attributed to RE. However, results from the available human clinical trials were controversial concerning the protective effects of RE against diseases and their sequelae. The reason for these conflicting findings is varied but differences in the characteristics of the enrolled patients, RE doses used, and duration of RE supplementation were proposed, at least in part, as possible causes. In particular, the optimal RE dosage capable of maximizing its health benefits without raising toxicity issues remains an area of extensive research. In this context, while there is a consistent body of literature on the protective effects of RE against diseases, there are relatively few reports investigating its possible toxicity. Indeed, toxicity and adverse effects were reported following consumption of RE; therefore, extensive future studies on the long-term effects, as well as the in vivo adverse effects, of RE supplementation in humans are needed. Furthermore, data on the interactions of RE when combined with other therapies are still lacking, as well as results related to its absorption and bioavailability in the human body. In this review, we collect and summarize the available literature about RE toxicity and side effects.In this process, we analyze in vitro and in vivo studies that have addressed this stilbenoid. These studies suggest that RE still has an unexplored side. Finally, we discuss the new delivery methods that are being employed to overcome the low bioavailability of RE.

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“…Peanuts are among the few plant species that produce resveratrol (Lanz et al, 1990;Sobolev and Cole, 1999;Arora and Japlan, 2018). This phenolic compound is a potent antioxidant (Frankel et al, 1993) whose healing and preventive potential for many human diseases were described in some recent reviews (Colica et al, 2018;Galiniak et al, 2019). Resveratrol is also a phytoalexin that has been associated with resistance to major peanut diseases (Sobolev et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Evidences that polyploidization and hybridization affected resveratrol content in Arachis interspecific hybrids

Carvalho¹,

Moretzsohn²,

Brasileiro³

et al. 2019

J. Plant Breed. Crop Sci.

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To broaden the genetic base of the allotetraploid peanut (Arachis hypogaea L.), pre-breeding programs have produced interspecific synthetic allotetraploids resulting from the chromosome duplication of hybrids between peanut related diploid species. These allotetraploids were highly cross-fertile with peanut making it possible to access the extensive genetic variability harbored by the wild species. This study aims to evaluate the impact of polyploidization and hybridization in resveratrol content in Arachis hybrids. Resveratrol is a potent antioxidant that has been shown to be useful in the treatment of many human diseases. For that, resveratrol was characterized in five synthetic allotetraploids of wild Arachis, six diploid wild species, three cultivars of A. hypogaea and three backcross (BC) hybrids between synthetic allotetraploids and A. hypogaea. Leaves from these genotypes were ultraviolet (UV) light irradiated for 2 h 30 min and their resveratrol contents were determined by high performance liquid chromatograph (HPLC). Resveratrol was found in all genotypes, but at variable concentrations. Synthetic allotetraploids and peanut did not differ and diploid species had the lowest resveratrol content. The highest concentrations were observed in hybrids between allotetraploids and cultivars of A. hypogaea that were probably the most heterozygous among the genotypes analyzed since their chromosome sets came from different species. This study data suggest a positive effect of polyploidy and hybridization in resveratrol content.

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Health benefits of resveratrol administration

Cited by 190 publications

References 119 publications

Pterostilbene Enhances Endurance Capacity via Promoting Skeletal Muscle Adaptations to Exercise Training in Rats

Pterostilbene Enhances Endurance Capacity via Promoting Skeletal Muscle Adaptations to Exercise Training in Rats

Potential Adverse Effects of Resveratrol: A Literature Review

Evidences that polyploidization and hybridization affected resveratrol content in Arachis interspecific hybrids

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