Oxidative metabolism of aldrin and isodrin by bean root fractions

Yu, S.J.; Kiigemagi, Ulo; Terriere, L. C.

doi:10.1021/jf60173a039

Cited by 42 publications

(23 citation statements)

References 8 publications

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“…Most of the activity was found in the microsomal fraction (105,000 g pellet). These results confirm those of Yu et al (1971) with beans al and peas and indicated that a mixed-function oxidase system was operating. To determine whether plant mixed-function oxidases are subject to the non-specific types of induction characteristic of animal systems, peas and lupins were grown in the presence of aniline and phenobarbital.…”

Section: Resultssupporting

confidence: 86%

“…The results of Yu et al (1971) demonstrated similarity between the aldrinmetabolizing systems in plants and animals. Our work confirms this similarity and extends it by demonstrating the inductive effects of aldrin and other substances known to induce drug metabolism in animals.…”

Section: IIImentioning

confidence: 80%

“…Assay of tissue homogenates of pea roots incubated with air and an NADPHgenerating system confirmed the results with intact plants. Yu et al (1971) reported that in bean homogenates aldrin disappearance was accounted for by production of dieldrin (80 %), aldrindiol (10 %) (Fig. 6), and water-soluble metabolites (2 %).…”

Section: Resultsmentioning

confidence: 97%

“…No attempt has yet been made to recover aldrindiol or other metabolites in this study but it is probable that the metabolism of aldrin is through the conversion to such substances rather than to dieldrin. Yu et al (1971) found no conversion of dieldrin to aldrindiol, although this is the mechanism in animal systems, and argued that the systems producing dieldrin and aldrindiol were separate even though they had identical requirements, including pH optima. It is not clear from the present work whether an induced rate of dieldrin metabolism, parallelling aldrin disappearance, occurs in pea roots.…”

Section: Resultsmentioning

confidence: 99%

“…Plant root extracts were prepared and assayed according to the method of Yu et al (1971). Roots were homogenized with O'IM sodium phosphate buffer, pH 6· 5 (1 g root in 1· 5 ml), squeezed through muslin, and the homogenate centrifuged at 22,000 g for 25 min.…”

Section: (E) Whole-plant Analysismentioning

confidence: 99%

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Pretreatment Effects on the Rates of Aldrin Metabolism in Pea Plants (Pisum Sativum)

Earl¹,

Kennedy²

1973

Aust. Jnl. Of Bio. Sci.

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A study has been made of the rate of aldrin metabolism by a number of plant species. In roots of pea seedlings grown in medium containing aldrin, the disappearance of aldrin was greater than the production of dieldrin, including that which could be accounted for by transport to the tops. By contrast, peas without aldrin pretreatment metabolized aldrin mainly to dieldrin by epoxidation.Measurements of enzymic activity with pea root extracts confirmed the inductive effect of aldrin pretreatment on the rate of aldrin metabolism.The aldrin-metabolizing activity showed similar characteristics to mammalian systems in that pretreatment with substances such as phenobarbital and aniline affected activity.Compared with other plant species grown in the presence of aldrin, peas maintained low levels of aldrin and dieldrin, although rates of aldrin uptake were similar, without showing the adverse effects on normal development which occurred in some plant species.

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Section: Resultssupporting

confidence: 86%

Section: IIImentioning

confidence: 80%

Section: Resultsmentioning

confidence: 97%

Section: Resultsmentioning

confidence: 99%

Section: (E) Whole-plant Analysismentioning

confidence: 99%

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