Biological oxidation and conjugation of pesticidal chemicals

Menzer, Robert E.

doi:10.1007/978-1-4615-8498-8_3

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1989

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Cited by 11 publications

(1 citation statement)

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“…This decrease in GSH concentration may modify the metabolic fate of compounds like acetaminophen [17,26] , organophosphates and halogenated hy drocarbons and some other xenobiotics [4,27] , A decrease in glutathione conjugation of an acetaminophen metabolite may contrib ute to the previously reported increase in the elimination half-life of this drug by CS [25].…”

Section: Discussionmentioning

confidence: 99%

Effect of Ciclosporin on Rat Liver and Kidney Glutathione Content

Duruibe

Okonmah²,

Blyden³

1989

Pharmacology

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The effect of ciclosporin (CS) on hepatic and renal glutathione was investigated in 36 male Sprague-Dawley rats weighing 200–250 g each. CS (120 µg/kg/day, i.p.) treatment caused a significant decrease in both hepatic and renal glutathione content. The rat hepatic glutathione levels decreased by 16 % within 1 h of a single CS treatment and continued decreasing to 50% following chronic treatment with CS for 7 days. Renal glutathione content decreased only marginally (3%) within 1 h of CS treatment. However, it decreased by 17% within 24 h and continued to decrease during the 7 days of chronic treatment. This decrease in the content of both hepatic and renal glutathione may contribute to the toxicity observed during treatment with CS.

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