Oxidative mechanisms of biological activity of low-intensity radiofrequency radiation

Yakymenko, Igor; Tsybulin, Оlexandr; Sidorik, Evgeniy; Henshel, Diane S.; Kyrylenko, Olga; Kyrylenko, Sergiy

doi:10.3109/15368378.2015.1043557

Cited by 184 publications

(141 citation statements)

References 168 publications

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“…These free radicals or ROS are an intrinsic part of the cellular signaling cascades (Forman et al, 2014). Therefore, low-intensity RF-EMR is an agent of ROS production, which may induce harmful effects in living cells (Yakymenko, et al, 2015). Additionally, microwaveinduced oxidative stress may produce ROS that are reported to be the main cause of cellular damage or tissue injury (Dasdag et al, 2008;Behari, 2009, 2012).…”

Section: Introductionmentioning

confidence: 97%

Microwave radiation (2.45 GHz)-induced oxidative stress: Whole-body exposure effect on histopathology of Wistar rats

Chauhan

Verma

Sisodia

et al. 2016

Electromagnetic Biology and Medicine

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Man-made microwave and radiofrequency (RF) radiation technologies have been steadily increasing with the growing demand of electronic appliances such as microwave oven and cell phones. These appliances affect biological systems by increasing free radicals, thus leading to oxidative damage. The aim of this study was to explore the effect of 2.45 GHz microwave radiation on histology and the level of lipid peroxide (LPO) in Wistar rats. Sixty-day-old male Wistar rats with 180 ± 10 g body weight were used for this study. Animals were divided into two groups: sham exposed (control) and microwave exposed. These animals were exposed for 2 h a day for 35 d to 2.45 GHz microwave radiation (power density, 0.2 mW/cm). The whole-body specific absorption rate (SAR) was estimated to be 0.14 W/kg. After completion of the exposure period, rats were sacrificed, and brain, liver, kidney, testis and spleen were stored/preserved for determination of LPO and histological parameters. Significantly high level of LPO was observed in the liver (p < 0.001), brain (p < 0.004) and spleen (p < 0.006) in samples from rats exposed to microwave radiation. Also histological changes were observed in the brain, liver, testis, kidney and spleen after whole-body microwave exposure, compared to the control group. Based on the results obtained in this study, we conclude that exposure to microwave radiation 2 h a day for 35 d can potentially cause histopathology and oxidative changes in Wistar rats. These results indicate possible implications of such exposure on human health.

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Section: Introductionmentioning

confidence: 97%

Microwave radiation (2.45 GHz)-induced oxidative stress: Whole-body exposure effect on histopathology of Wistar rats

Chauhan

Verma

Sisodia

et al. 2016

Electromagnetic Biology and Medicine

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“…Increasing evidence has demonstrated that exposure to RF-EMFs radiation may induce oxidative stress [25], followed by cellular oxidative damage, i.e., oxidative DNA damage [26,27]. Oxidative stress is a condition induced by oxygen and oxygen-derived free radicals.…”

Section: Introductionmentioning

confidence: 99%

8-oxoG DNA Glycosylase-1 Inhibition Sensitizes Neuro-2a Cells to Oxidative DNA Base Damage Induced by 900 MHz Radiofrequency Electromagnetic Radiation

Wang

Liu

et al. 2015

Cell Physiol Biochem

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Background/Aims: The purpose of this study was to explore the in vitro putative genotoxicity during exposure of Neuro-2a cells to radiofrequency electromagnetic fields (RF-EMFs) with or without silencing of 8-oxoG DNA glycosylase-1 (OGG1). Methods: Neuro-2a cells treated with or without OGG1 siRNA were exposed to 900 MHz Global System for Mobile Communication (GSM) Talk signals continuously at a specific absorption rate (SAR) of 0, 0.5, 1 or 2 W/kg for 24 h. DNA strand breakage and DNA base damage were measured by the alkaline comet assay and a modified comet assay using formamidopyrimidine DNA glycosylase (FPG), respectively. Reactive oxygen species (ROS) levels and cell viability were monitored using the non-fluorescent probe 2, 7-dichlorofluorescein diacetate (DCFH-DA) and CCK-8 assay. Results: Exposure to 900 MHz RF-EMFs with insufficient energy could induce oxidative DNA base damage in Neuro-2a cells. These increases were concomitant with similar increases in the generation of reactive oxygen species (ROS). Without OGG1 siRNA, 2 W/kg RF-EMFs induced oxidative DNA base damage in Neuro-2a cells. Interestingly, with OGG1 siRNA, RF-EMFs could cause DNA base damage in Neuro-2a cells as low as 1 W/kg. However, neither DNA strand breakage nor altered cell viability was observed. Conclusion: Even if further studies remain conducted we support the hypothesis that OGG1 is involved in the process of DNA base repair and may play a pivotal role in protecting DNA bases from RF-EMF induced oxidative damage.

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“…• Salivary gland tumors [7,8] • Dizziness and migraines [9] • Less sleep and poor sleep quality [10] • Increases and decreases in production of specific proteins in human cells [11] • Decreased sperm count and quality [12][13][14] • Skin irritation, especially on the face (this is a condition known as electrohypersensitivity) [15,16] • Behavioral problems and increased chance of cancer tumor development in children.…”

Section: Increases Risk Of Eye Vision Problemsmentioning

confidence: 99%

Untitled

Deepti

2016

IJGP

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Today, we are living in an advanced technological world, and as we are in such technological world, we can name this period as "technology age" as well as "radiation age." People today are bombarded with radiations from the sources they use every day such as laptops, cell phones, headphones, refrigerators, micro ovens, radio towers, televisions, satellites, broadcast antennas, and such more. The exposure to such radiations does not go away over time, in fact, it shows its effects on the body slowly based on their usage, and the effects so produced from such radiations are called as electromagnetic hypersensitivity reactions (or) electromagnetic hypersensitivity syndrome. The health professionals are facing challenges regarding the symptoms on prolonged exposure to frequencies of radiation (electromagnetic radiation [EMR]). Various organizations like the World Health Organization and some nation states started exploring about this clinical phenomenon to explain the prevalence of symptoms associated with non-ionizing EMR exposure. This article explains in detail regarding the common sources that produce EMR, its effects, and preventive measures to overcome such effects.

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Oxidative mechanisms of biological activity of low-intensity radiofrequency radiation

Cited by 184 publications

References 168 publications

Microwave radiation (2.45 GHz)-induced oxidative stress: Whole-body exposure effect on histopathology of Wistar rats

Microwave radiation (2.45 GHz)-induced oxidative stress: Whole-body exposure effect on histopathology of Wistar rats

8-oxoG DNA Glycosylase-1 Inhibition Sensitizes Neuro-2a Cells to Oxidative DNA Base Damage Induced by 900 MHz Radiofrequency Electromagnetic Radiation

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